Allison Volf
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View article: Bidirectional Modification of a <i>Galbulimima</i> Alkaloid Identifies Selective Opioid Ligands
Bidirectional Modification of a <i>Galbulimima</i> Alkaloid Identifies Selective Opioid Ligands Open
We report a bidirectional diversification and optimization campaign of the newly identified mu- and kappa-opioid receptor antagonist GB18, a naturally occurring Galbulimima alkaloid. First, we find that replacement of the GB18 piperidine w…
View article: Bidirectional modification of a Galbulimima alkaloid identifies selective opioid ligands
Bidirectional modification of a Galbulimima alkaloid identifies selective opioid ligands Open
We report a bidirectional diversification and optimization campaign of the newly identified mu- and kappa-opioid receptor antagonist GB18, a naturally occurring Galbulimima alkaloid. First, we find that replacement of the GB18 piperidine w…
View article: Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice
Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice Open
Kappa opioid receptor agonists are clinically used to treat pruritis and have therapeutic potential for the treatment of pain and neuropsychiatric disorders. We have previously shown that triazole 1.1 is a G protein signaling-biased KOR ag…