Allison W. Willis
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Comorbidity Risk Assessment in Medicare Beneficiaries with Neurodevelopmental Disorders Open
Neurodevelopmental disorders (NDDs) are lifelong conditions that affect brain development and functioning, with varying levels of impairment on daily life. Advances in technology have extended life expectancy for individuals with NDDs; how…
View article: Comparing retrospective informant assessments to prospectively collected cognitive measures in the Health and Retirement Study
Comparing retrospective informant assessments to prospectively collected cognitive measures in the Health and Retirement Study Open
INTRODUCTION Clinicians and researchers frequently ask informants about changes in a person's cognition, but whether informant assessments correspond to objectively measured change is unclear. METHODS A subset ( n = 2710) of US Health and …
View article: Examining the effects of race/ethnicity and other factors on outcomes of care for complex regional pain syndrome type 1 in the United States
Examining the effects of race/ethnicity and other factors on outcomes of care for complex regional pain syndrome type 1 in the United States Open
Complex regional pain syndrome is a chronic pain disorder marked by symptoms such as swelling, impaired motor function, and sympathetic dysfunction. Our primary objective was to determine the total number of complex regional pain syndrome …
View article: Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in Parkinson Disease
Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in Parkinson Disease Open
Purpose Anticholinergic medication use measured via the Anticholinergic Cognitive Burden (ACB) scale has been associated with an increased dementia incidence in older adults but has not been explored specifically for Parkinson disease deme…
Impact of pimavanserin on prescribing practices in parkinson disease Open
The availability of pimavanserin was followed by a decline in the use of the most harmful AAPs in persons living with PD. Quetiapine remained the most prescribed AAP. Comparative safety and effectiveness studies are needed to define the re…
View article: End-of-Life Health Care Service Use and Cost Among Medicare Decedents With Neurodegenerative Diseases
End-of-Life Health Care Service Use and Cost Among Medicare Decedents With Neurodegenerative Diseases Open
Persons with neurodegenerative diseases in the United States are more likely to visit the ED and less likely to use inpatient and hospice services at EoL than persons with brain or pancreatic cancer. These group differences may stem from p…
View article: Long-Term Dementia Risk in Parkinson Disease
Long-Term Dementia Risk in Parkinson Disease Open
Results from two large, prospective studies suggest that dementia in PD occurs less frequently, or later in the disease course, than previous research studies have reported.
View article: Non-Ergot Dopamine Agonists and the Risk of Heart Failure and Other Adverse Cardiovascular Reactions in Parkinson’s Disease
Non-Ergot Dopamine Agonists and the Risk of Heart Failure and Other Adverse Cardiovascular Reactions in Parkinson’s Disease Open
Reports suggest possible risks of adverse cardiovascular reactions, including heart failure, associated with non-ergot dopamine agonist (DA) use in Parkinson’s disease (PD). The objectives of our review were to evaluate the risk of heart f…
View article: Application of High-Dimensional Propensity Score Methods to the National Health and Aging Trends Study
Application of High-Dimensional Propensity Score Methods to the National Health and Aging Trends Study Open
Background High-dimensional propensity scoring (HDPS) is a method for empirically identifying potential confounders within large healthcare databases such as administrative claims data. However, this method has not yet been applied to larg…
View article: Fostering Inclusivity in Research Engagement for Underrepresented Populations in Parkinson's Disease: The FIRE-UP PD study
Fostering Inclusivity in Research Engagement for Underrepresented Populations in Parkinson's Disease: The FIRE-UP PD study Open
Research participation demographics reflective of the general population are critical to PD investigation and treatment. The FIRE-UP PD Study showed the effectiveness of localized community engagement strategies in increasing URG recruitme…
View article: Interaction between visual impairment and genetic risk of dementia and psychosis in older adults
Interaction between visual impairment and genetic risk of dementia and psychosis in older adults Open
Background Visual impairment (VI) is associated with dementia and other neuropsychiatric outcomes, but previous studies have not considered genetic sources of confounding or effect modification. Methods We analysed data from the Health and…
Thinking Three‐Dimensionally: A Self‐ and Externally‐Controlled Approach to Screening for Drug–Drug–Drug Interactions Among High‐Risk Populations Open
The global rise in polypharmacy has increased both the necessity and complexity of drug–drug interaction (DDI) assessments, given the growing potential for interactions involving more than two drugs. Leveraging large‐scale healthcare claim…
View article: Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level
Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level Open
Observational studies in Parkinson’s disease (PD) deeply characterize relatively small numbers of participants. The Molecular Integration in Neurological Diagnosis Initiative seeks to characterize molecular and clinical features of every P…
View article: Molecular Integration in Neurological Diagnosis (MIND) Parkinson's Disease Inception Cohort Study Protocol
Molecular Integration in Neurological Diagnosis (MIND) Parkinson's Disease Inception Cohort Study Protocol Open
This is an inception cohort study protocol to enroll people with Parkinson's disease into a biobanking protocol at the clinic-wide level collecting clinical information and blood for future research use. The informed consent process includ…
View article: Nationwide emergency department visits for pediatric traumatic spinal cord injury in the United States, 2016–2020
Nationwide emergency department visits for pediatric traumatic spinal cord injury in the United States, 2016–2020 Open
Introduction Traumatic spinal cord injury (tSCI) is a debilitating neurological condition resulting in lifelong disability for many individuals. The primary objectives of our study were to describe national trends in incident emergency dep…
View article: Defining Key Deprescribing Measures from Electronic Health Data: A Multisite Data Harmonization Project
Defining Key Deprescribing Measures from Electronic Health Data: A Multisite Data Harmonization Project Open
Background Deprescribing, or systematically stopping or reducing risky or unneeded medications, could improve older adults’ health. Electronic health records (EHR) hold promise for supporting deprescribing studies, but there are currently …
View article: Unique characteristics of end-of-life hospitalizations in Parkinson disease
Unique characteristics of end-of-life hospitalizations in Parkinson disease Open
Introduction Persons with Parkinson disease (PD) are hospitalized at higher rates, have longer lengths of stay, and are more likely to die in the hospital than age-matched peers. Although prior studies have compared inpatient outcomes betw…
View article: Health equity integrated epilepsy care and research: A narrative review
Health equity integrated epilepsy care and research: A narrative review Open
Background With the unanimous approval of the Intersectoral Global Action Plan on epilepsy and other neurological disorders by the World Health Organization in May 2022, there are strong imperatives to work towards equitable neurological c…
Care access and utilization among medicare beneficiaries living with Parkinson’s disease Open
An estimated 90% of people living with Parkinson’s disease (PD) in the US are covered by Medicare health insurance. How these beneficiaries use and engage the health care system is important to understand in the face of a rapidly growing P…
View article: JAMA Neurology
JAMA Neurology Open
The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and dise…
View article: Adjusting for Underrepresentation Reveals Widespread Underestimation of Parkinson's Disease Symptom Burden
Adjusting for Underrepresentation Reveals Widespread Underestimation of Parkinson's Disease Symptom Burden Open
Background Clinical research is limited by underrepresentation, but the impact of underrepresentation on patient‐reported outcomes in Parkinson's disease (PD) is unknown. Objectives To produce nationwide estimates of non‐motor symptom (NMS…
View article: JAMA Neurology
JAMA Neurology Open
The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and dise…
View article: Sociodemographic and Geographic Disparities in End-of-Life Health Care Intensity Among Medicare Beneficiaries With Parkinson Disease
Sociodemographic and Geographic Disparities in End-of-Life Health Care Intensity Among Medicare Beneficiaries With Parkinson Disease Open
Most persons with PD in the US are hospitalized in the last 6 months of life, and treatment intensity varies by sex, race, ethnicity, and geographic location. These group differences emphasize the importance of exploring end-of-life care p…
View article: Bibliometric analysis of published research on pediatric health disparities
Bibliometric analysis of published research on pediatric health disparities Open
This study aimed to examine the current evidence in the medical literature on health disparities in the pediatric population. A bibliometric analysis of published research focused on health disparities in pediatric patients was conducted t…
View article: Racial and Ethnic Disparities in Parkinson Disease
Racial and Ethnic Disparities in Parkinson Disease Open
Health disparities are pervasive in the United States. In the field of Parkinson disease (PD), profound racial and ethnic disparities exist in diagnosis, treatment, and research participation, leading to differential health outcomes and la…