Prasanna Alluri
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View article: Ablative Preoperative Single-Fraction Radiation Dose Escalation Among Patients With Breast Cancer
Ablative Preoperative Single-Fraction Radiation Dose Escalation Among Patients With Breast Cancer Open
Importance Single-fraction preoperative ablative stereotactic partial breast irradiation (sPBI) can be safely delivered in early-stage hormone receptor–positive (HR + ) breast cancer with delayed time to surgery and high pathologic complet…
View article: The non-kinase function of CDK6 is a key driver of acquired resistance to CDK4/6 inhibitors in Estrogen Receptor-positive breast cancer
The non-kinase function of CDK6 is a key driver of acquired resistance to CDK4/6 inhibitors in Estrogen Receptor-positive breast cancer Open
The therapeutic efficacy of CDK4/6 inhibitors in ER+ breast cancer (BC) patients is presumed to arise from inhibition of the kinase function of CDK4 and 6 proteins. Despite their initial efficacy, development of acquired resistance to CDK4…
View article: Assessment of cardiac radiation dose in the Co-60 prone-based stereotactic partial breast irradiation using distance metrics
Assessment of cardiac radiation dose in the Co-60 prone-based stereotactic partial breast irradiation using distance metrics Open
Purpose/objective(s) The GammaPod™ (GP) system, a contemporary platform dedicated to breast cancer (BC) radiotherapy, facilitates the delivery of accelerated partial breast irradiation (APBI) via the Co-60 prone-based stereotactic partial …
View article: Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma (Adv. Sci. 22/2025)
Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma (Adv. Sci. 22/2025) Open
View article: HCK regulates NLRP12-mediated PANoptosis
HCK regulates NLRP12-mediated PANoptosis Open
NOD-like receptors (NLRs) are a highly conserved family of cytosolic pattern recognition receptors that drive innate immune responses against pathogens, pathogen-associated molecular patterns, damage-associated molecular patterns, and home…
View article: Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma
Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma Open
Despite the recent successes of immune checkpoint inhibitors (ICIs) in treating advanced melanoma, durable clinical responses still remain limited. To boost immune responses, agents that target immune regulators, such as the Stimulator of …
View article: Addressing algorithmic bias in precision well-being for medical education: A socially fair approach for clustering
Addressing algorithmic bias in precision well-being for medical education: A socially fair approach for clustering Open
Background Medical students frequently experience heightened levels of anxiety, depression, and burnout. These challenges are disproportionately borne by students from underrepresented backgrounds, who are exposed to systemic inequities, d…
View article: Multimodal radiotherapy dose prediction using a multi‐task deep learning model
Multimodal radiotherapy dose prediction using a multi‐task deep learning model Open
Background In radiation therapy (RT), accelerated partial breast irradiation (APBI) has emerged as an increasingly preferred treatment modality over conventional whole breast irradiation due to its targeted dose delivery and shorter course…
View article: Master Breast Radiation Planning: Simple Guide for Radiation Oncology Residents
Master Breast Radiation Planning: Simple Guide for Radiation Oncology Residents Open
This article focuses on various aspects of breast radiation treatment planning, from simulation to field design. It covers the most common techniques including tangents, mono isocentric, dual isocentric, electron-photon match, and VMAT. Th…
View article: Targeting Non-Kinase Function of CDK6 to Overcome CDK4/6 Inhibitor Resistance
Targeting Non-Kinase Function of CDK6 to Overcome CDK4/6 Inhibitor Resistance Open
View article: Racial Difference in Outcomes in Breast Cancer Patients with Residual Nodal Disease after Neoadjuvant Chemotherapy
Racial Difference in Outcomes in Breast Cancer Patients with Residual Nodal Disease after Neoadjuvant Chemotherapy Open
View article: Assessment of Cardiac Radiation Dose in the Co-60 Prone Based Stereotactic Partial Breast Irradiation (CP-sPBI) Using the Distance from the Heart to the Planning Treatment Volume as a Surrogate Marker
Assessment of Cardiac Radiation Dose in the Co-60 Prone Based Stereotactic Partial Breast Irradiation (CP-sPBI) Using the Distance from the Heart to the Planning Treatment Volume as a Surrogate Marker Open
View article: A deep learning approach for automatic delineation of clinical target volume in stereotactic partial breast irradiation (S-PBI)
A deep learning approach for automatic delineation of clinical target volume in stereotactic partial breast irradiation (S-PBI) Open
Accurate and efficient delineation of the clinical target volume (CTV) is of utmost significance in post-operative breast cancer radiotherapy. However, CTV delineation is challenging as the exact extent of microscopic disease encompassed b…
View article: Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy Open
View article: Aspirin Use Is Associated With Improved Outcomes in Inflammatory Breast Cancer Patients
Aspirin Use Is Associated With Improved Outcomes in Inflammatory Breast Cancer Patients Open
ASA use during remission was associated with significantly improved OS and DMFS in patients with IBC. These results suggest that ASA may provide survival benefits to patients with IBC. Prospective clinical trials of ASA use in patients wit…
View article: On the Possibility of Estimating Myocardial Fiber Architecture from Cardiac Strains
On the Possibility of Estimating Myocardial Fiber Architecture from Cardiac Strains Open
View article: Feasibility and efficacy of active breathing coordinator assisted deep inspiration breath hold technique for treatment of locally advanced breast cancer
Feasibility and efficacy of active breathing coordinator assisted deep inspiration breath hold technique for treatment of locally advanced breast cancer Open
Background Active breathing coordinator (ABC)‐assisted deep inspiration breath hold (DIBH) is an important organ sparing radiation therapy (RT) technique for left‐sided breast cancer patients. Patients with advanced breast cancer undergoin…
View article: On the feasibility of improved target coverage without compromising organs at risk using online adaptive stereotactic partial breast irradiation (A‐SPBI)
On the feasibility of improved target coverage without compromising organs at risk using online adaptive stereotactic partial breast irradiation (A‐SPBI) Open
Purpose Describe an early‐adopting institution's experience with online adaptive radiation for stereotactic partial breast irradiation. Methods and materials Retrospective review of 22 women treated between May 2021 and March 2022 with ada…
View article: Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition
Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition Open
Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in patients with metastatic ER+ breast cancer. The ESR1 Y537S mutation, in particul…
View article: Targeting radioresistance and replication fork stability in prostate cancer
Targeting radioresistance and replication fork stability in prostate cancer Open
The bromodomain and extraterminal (BET) family of chromatin reader proteins bind to acetylated histones and regulate gene expression. The development of BET inhibitors (BETi) has expanded our knowledge of BET protein function beyond transc…
View article: Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness Open
HER2+ breast cancer patients are presented with either synchronous (S-BM), latent (Lat), or metachronous (M-BM) brain metastases. However, the basis for disparate metastatic fitness among disseminated tumor cells of similar oncotype within…
View article: Preliminary Results of Multi-Institutional Phase 1 Dose Escalation Trial Using Single-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer
Preliminary Results of Multi-Institutional Phase 1 Dose Escalation Trial Using Single-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer Open
This phase 1 trial demonstrates that S-PBI can be used to safely escalate dose to 30 Gy in a single fraction with low toxicity and without detriment in cosmesis relative to baseline.
View article: Saliency-Guided Deep Learning Network for Automatic Target Delineation in Post-Operative Stereotactic Partial Breast Irradiation
Saliency-Guided Deep Learning Network for Automatic Target Delineation in Post-Operative Stereotactic Partial Breast Irradiation Open
View article: Early Follow-Up of Multi-Institutional Trial of Phase I Dose Escalation Using Single Fraction Stereotactic Partial Breast Irradiation (S-PBI) for Early-Stage Breast Cancer
Early Follow-Up of Multi-Institutional Trial of Phase I Dose Escalation Using Single Fraction Stereotactic Partial Breast Irradiation (S-PBI) for Early-Stage Breast Cancer Open
View article: Cosmetic Outcomes of a Phase 1 Dose Escalation Study of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer
Cosmetic Outcomes of a Phase 1 Dose Escalation Study of 5-Fraction Stereotactic Partial Breast Irradiation for Early Stage Breast Cancer Open
Dose escalation of S-PBI from 30 to 40 Gy in 5 fractions for early stage breast cancer was not associated with a detectable change in cosmesis by year 3. S-PBI is a promising modality for treatment of early stage breast cancer.
View article: LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation
LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation Open
View article: HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol
HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol Open
HOXA5 is a homeobox-containing gene associated with the development of the lung, gastrointestinal tract, and vertebrae. Here, we investigate potential roles and the gene regulatory mechanism in HOXA5 in breast cancer cells. Our studies dem…
View article: Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers
Estrogen receptor coregulator binding modulator (ERX-11) enhances the activity of CDK4/6 inhibitors against estrogen receptor-positive breast cancers Open
Background CDK4/6 inhibitors in combination with endocrine therapy (AE/AI/SERDs) are approved for the treatment of ER+ advanced breast cancer (BCa). However, not all patients benefit from CDK4/6 inhibitors therapy. We previously reported a…
View article: Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer
Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer Open
Increased rates of locoregional recurrence have been observed in triple-negative breast cancer despite chemotherapy and radiation therapy. Thus, approaches that combine therapies for radiosensitization in triple-negative breast cancer are …
View article: Androgen Receptor (AR) As a Mediator and Biomarker of Radioresistance in Triple-Negative Breast Cancer
Androgen Receptor (AR) As a Mediator and Biomarker of Radioresistance in Triple-Negative Breast Cancer Open