Allyson Huttinger
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View article: Von Willebrand factor targeted thrombolysis in canine basilar artery occlusion
Von Willebrand factor targeted thrombolysis in canine basilar artery occlusion Open
Background and purpose Posterior circulation strokes, accounting for 20% of acute ischemic strokes, significantly contribute to morbidity and mortality. Fibrinolysis by rtPA improves outcomes in stroke but the risk of intracranial hemorrha…
View article: P28. Socioeconomic Disparities in Extended Research Experience Participation: Bias in the Integrated Plastic Surgery Residency Match
P28. Socioeconomic Disparities in Extended Research Experience Participation: Bias in the Integrated Plastic Surgery Residency Match Open
PURPOSE: Integrated plastic surgery residency applicants have increased at a rate disproportionate to available positions. Research productivity has become a surrogate marker for competitiveness, and many applicants pursue extended researc…
View article: 22. Socioeconomic Disparities in Extended Research Experience Participation: Bias in the Integrated Plastic Surgery Residency Match
22. Socioeconomic Disparities in Extended Research Experience Participation: Bias in the Integrated Plastic Surgery Residency Match Open
Background: Integrated plastic surgery residency applicants have increased at a rate disproportionate to available positions. Research productivity has become a surrogate marker for competitiveness, and many applicants pursue extended rese…
View article: A canine thromboembolic model of anterior circulation large vessel occlusion stroke
A canine thromboembolic model of anterior circulation large vessel occlusion stroke Open
We demonstrate a thromboembolic canine model of MCAO that is both feasible and results in consistent infarct volumes to generate a clinically relevant LVO. This model is important to evaluate treatment of LVO in acute ischemic stroke (AIS)…
View article: A Canine Thromboembolic Model of Anterior Circulation Large Vessel Occlusion Stroke
A Canine Thromboembolic Model of Anterior Circulation Large Vessel Occlusion Stroke Open
View article: PERK Inhibition Mitigates Restenosis and Thrombosis
PERK Inhibition Mitigates Restenosis and Thrombosis Open
Developing endothelial-protective, nonthrombogenic antirestenotic treatments has been a challenge. A major hurdle to this has been the identification of a common molecular target in both smooth muscle cells and endothelial cells, inhibitio…
View article: Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels
Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels Open
Endothelial surface and circulating glycoprotein von Willebrand factor (vWF) regulates platelet adhesion and is associated with thrombotic diseases, including ischemic stroke, myocardial infarction, and peripheral vascular disease. Thrombo…
View article: PERK inhibition mitigates restenosis and thrombosis - a potential low-thrombogenic anti-restenotic paradigm
PERK inhibition mitigates restenosis and thrombosis - a potential low-thrombogenic anti-restenotic paradigm Open
Background Drug-eluting stents (DES) represent the main-stream management of restenosis following treatments of occlusive cardiovascular diseases. However, DES cannot eliminate instent restenosis yet exacerbate thrombogenic risks. To achie…
View article: Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury Open
Occlusive arterial thrombosis leading to cerebral ischemic stroke and myocardial infarction contributes to ~13 million deaths every year globally. Here, we have translated a vascular injury model from a small animal into a large animal (ca…