Explanipedia

Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer Open

Heather M. McGee, Joseph D. Bonner, Colt A. Egelston, Yubo Fu, Oscar Colunga Flores , et al. · 2024

The incidence of colorectal cancer (CRC) among individuals under age 50, or early-onset CRC (EOCRC), has been rising over the past few decades for unclear reasons, and the etiology of the disease remains largely unknown. Known genetic risk…

A Highly Sensitive Pan-Cancer Test for Microsatellite Instability Open

Jeffery W. Bacher, Eshwar Udho, Ethan E. Strauss, Irina Vyazunova, Steven Gallinger , et al. · 2023

Cancer Risk C (CR-C), a functional genomics test is a sensitive and rapid test for germline mismatch repair deficiency Open

Ishraq Alim, Johnny Loke, Sarah Yam, Allyson Templeton, Polly A. Newcomb , et al. · 2022

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study Open

Aung Ko Win, James G. Dowty, Jeanette C. Reece, Grant Lee, Allyson Templeton , et al. · 2021

Genome‐wide association study of circulating folate one‐carbon metabolites Open

Jun Wang, Isaac Asante, John A. Baron, Jane C. Figueiredo, Robert W. Haile , et al. · 2019

Experimental, observational, and clinical trials support a critical role of folate one‐carbon metabolism (FOCM) in colorectal cancer (CRC) development. In this report, we focus on understanding the relationship between common genetic varia…

Worldwide Practice Patterns in Lynch Syndrome Diagnosis and Management, Based on Data From the International Mismatch Repair Consortium Open

Jennifer Pan, Robert W. Haile, Allyson Templeton, Finlay Macrae, Feifei Qin , et al. · 2018

Genomic Characterization of Upper-Tract Urothelial Carcinoma in Patients With Lynch Syndrome Open

Timothy F. Donahue, Aditya Bagrodia, François Audenet, Mark T.A. Donoghue, K. Eugene , et al. · 2018

Purpose Patients with Lynch syndrome (LS) have a significantly increased risk of developing upper-tract urothelial carcinoma (UTUC). Here, we sought to identify differences in the patterns of mutational changes in LS-associated versus spor…

Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC) Open

Mark A. Jenkins, Aung Ko Win, Allyson Templeton, Maggie S Angelakos, Daniel D. Buchanan , et al. · 2018

Mark A Jenkins, Aung Ko Win, Allyson S Templeton, Maggie S Angelakos, Daniel D Buchanan, Michelle Cotterchio, Jane C Figueiredo, Stephen N Thibodeau, John A Baron, John D Potter, John L Hopper, Graham Casey, Steven Gallinger, Loic Le March…

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