Alma Martelli
YOU?
Author Swipe
View article: Drugs for transthyretin amyloidosis under the microscope: Survival, safety, and a meta-analysis with certainty of evidence assessment
Drugs for transthyretin amyloidosis under the microscope: Survival, safety, and a meta-analysis with certainty of evidence assessment Open
Transthyretin amyloidosis (ATTR) is an infiltrative disease caused by the deposition of misfolded transthyretin (TTR) fibrils in organs and tissues, with incidence and prevalence rapidly increasing worldwide. Current therapeutic strategies…
View article: Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches
Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches Open
Remission of type 2 diabetes (T2D) can occur after hypocaloric diet, bariatric surgery, or pharmacological treatments and associates with improved β cell function. Here, we studied islets from nondiabetic ( n = 15) and T2D ( n = 21) donors…
View article: Real-World Pilot Evaluation of a Novel Bioavailable Berberine Formulation (ToBeRock®) in Subjects with Impaired Fasting Glucose Through Pharmacy-Based Retrospective Study
Real-World Pilot Evaluation of a Novel Bioavailable Berberine Formulation (ToBeRock®) in Subjects with Impaired Fasting Glucose Through Pharmacy-Based Retrospective Study Open
Berberine, a natural isoquinoline alkaloid, has been shown to improve glycemic control, lipid metabolism, and blood pressure regulation. However, its poor bioavailability has limited widespread clinical use. ToBeRock® is a self-emulsifying…
View article: Effects of Clonapure<sup>®</sup> Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players
Effects of Clonapure<sup>®</sup> Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players Open
<i>Background: </i>Creatine supplementation has long been established as a performance-enhancing strategy in power and strength-based sports. However, evidence in elite female athletes and in volleyball-specific contexts remain…
View article: Transsulfuration Pathway Products and H2S-Donors in Hyperhomocysteinemia: Potential Strategies Beyond Folic Acid
Transsulfuration Pathway Products and H2S-Donors in Hyperhomocysteinemia: Potential Strategies Beyond Folic Acid Open
The transsulfuration pathway plays a central role in the regulation of sulfur metabolism and contributes to the maintenance of cellular homeostasis. Starting from homocysteine, a sulfur-containing amino acid derived from methionine via the…
View article: Bromelain‐Rich Pineapple Extract for the Treatment of Pediatric Patients With <i>Orchiepididymitis</i>: A Randomized Clinical Pilot Study
Bromelain‐Rich Pineapple Extract for the Treatment of Pediatric Patients With <i>Orchiepididymitis</i>: A Randomized Clinical Pilot Study Open
A freeze‐dried pineapple extract—Brome‐Inf, from pineapple by‐products of industrial rings production, was enriched in bioactive polypeptides and bromelain by membrane ultrafiltration. Orchiepididymitis (OE), a painful pediatric pathology,…
View article: The H2S-donor Erucin modulates SIRT1 and rescues obesity-induced vascular dysfunction in human vessels
The H2S-donor Erucin modulates SIRT1 and rescues obesity-induced vascular dysfunction in human vessels Open
Evidence highlights the potential role of hydrogen sulfide (H₂S)-donors in preventing vascular dysfunction by modulating pathways associated with oxidative stress. We investigate the H₂S-donor Erucin for its potential to reduce oxidative s…
View article: Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas
Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas Open
Trimethylamine N-oxide (TMAO) is an endogenous osmolyte produced by enzymatic reactions starting in the human gut, where microbiota release trimethylamine (TMA) from foods, and ending in the liver, where TMA is oxidized to TMAO by flavin-c…
View article: Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug
Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug Open
Background Obesity is a metabolic disease that is characterized by an excessive accumulation of adipose tissue (AT) and is often associated with other pathologies. AT is a lipid storage organ with endocrine functions that presents two main…
View article: Benefits of Camelina sativa Supplementation in Morphine Treatment: Enhanced Analgesia, Delayed Tolerance and Reduced Gut Side Effects Through PPAR-α Receptor Engagement
Benefits of Camelina sativa Supplementation in Morphine Treatment: Enhanced Analgesia, Delayed Tolerance and Reduced Gut Side Effects Through PPAR-α Receptor Engagement Open
Long-term opioid therapies are severely limited by the development of analgesic tolerance and gastrointestinal side effects. Camelina sativa, a plant of the Brassicaceae family, modulates the activity of peroxisome proliferator-activated r…
View article: Semi-Synthetic H2s Releasing Compounds with Antioxidant and Vasorelaxant Properties
Semi-Synthetic H2s Releasing Compounds with Antioxidant and Vasorelaxant Properties Open
View article: Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules
Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules Open
Alzheimer's disease (AD) represents one of the main challenges for the 21st century medical research as no disease-modifying agent has been successfully progressed to the market, while the number of people affected by AD is estimated to gr…
View article: The Effect of Thermal Processes on the Organoleptic and Nutraceutical Quality of Tomato Fruit (Solanum lycopersicum L.)
The Effect of Thermal Processes on the Organoleptic and Nutraceutical Quality of Tomato Fruit (Solanum lycopersicum L.) Open
The present study investigated the changes in the organoleptic characteristics, nutraceuticals, and antioxidant activity of tomato fruits subjected to different thermal processes: tomato sauce (80 °C for 30 min), blanching treatment (100 °…
View article: In Vitro Models of Diabetes: Focus on Diabetic Retinopathy
In Vitro Models of Diabetes: Focus on Diabetic Retinopathy Open
Diabetic retinopathy is a major eye complication in patients with diabetes mellitus, and it is the leading cause of blindness and visual impairment in the world. Chronic hyperglycemia induces endothelial damage with consequent vascular les…
View article: <i>Alliaceae</i> versus <i>Brassicaceae</i> for Dyslipidemia: State of the Art and Future Perspectives. Systematic Review and Meta‐Analysis of Clinical Studies
<i>Alliaceae</i> versus <i>Brassicaceae</i> for Dyslipidemia: State of the Art and Future Perspectives. Systematic Review and Meta‐Analysis of Clinical Studies Open
Dyslipidemia is a risk factor for cardiovascular diseases. Preclinical studies have shown that organosulfur compounds from the Alliaceae and Brassicaceae plants, such as garlic ( Allium sativum L.) and broccoli ( Brassica oleracea L.), hav…
View article: Gut-vascular axis and postbiotics: The pharmacological potential of metabolites encourages broader definitions
Gut-vascular axis and postbiotics: The pharmacological potential of metabolites encourages broader definitions Open
View article: Impact of thermal processing on polyphenols, carotenoids, glucosinolates, and ascorbic acid in fruit and vegetables and their cardiovascular benefits
Impact of thermal processing on polyphenols, carotenoids, glucosinolates, and ascorbic acid in fruit and vegetables and their cardiovascular benefits Open
Bioactive compounds in fruit and vegetables have a positive impact on human health by reducing oxidative stress, inflammation, and the risk of chronic diseases such as cancer, cardiovascular (CV) diseases, and metabolic disorders. However,…
View article: Microbiota alterations associated with vascular diseases: postbiotics as a next-generation magic bullet for gut-vascular axis
Microbiota alterations associated with vascular diseases: postbiotics as a next-generation magic bullet for gut-vascular axis Open
The intestinal microbiota represents a key element in maintaining the homeostasis and health conditions of the host. Vascular pathologies and other risk factors such as aging have been recently associated with dysbiosis. The qualitative an…
View article: Isothiocyanate-Corticosteroid Conjugates against asthma: Unity makes strength
Isothiocyanate-Corticosteroid Conjugates against asthma: Unity makes strength Open
Asthma is a major noncommunicable disease, affecting both children and adults, and represents one of the major causes leading to high health care costs due to the need for chronic pharmacological treatments. The standard gold therapy of in…
View article: How effective are prescriptive governance tools? Results from the application of AIFA notes
How effective are prescriptive governance tools? Results from the application of AIFA notes Open
Introduction: Prescription appropriateness is crucial for healthcare, balancing scientific evidence, optimal benefit/risk ratios and cost-effectiveness in alignment with the National Health System (NHS) sustainability. In Italy, various go…
View article: Erucin, a natural isothiocyanate, exerts pro‐angiogenic properties in cultured endothelial cells and reverts angiogenic impairment induced by high glucose
Erucin, a natural isothiocyanate, exerts pro‐angiogenic properties in cultured endothelial cells and reverts angiogenic impairment induced by high glucose Open
Insufficient vessel maintenance adversely impacts patients in terms of tissue reperfusion following stroke or myocardial infarction, as well as during wound healing. Angiogenesis impairment is a feature typical of metabolic disorders actin…
View article: An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study
An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study Open
A three-arm, randomized, placebo-controlled clinical study was conducted to assess the impact of lyophilized pineapple extract with titrated bromelain (Brome-Inf®) and purified bromelain on pain, swelling, trismus, and quality of life (QoL…
View article: Evaluation of Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study
Evaluation of Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study Open
A three-arm, randomized, placebo controlled clinical study has been performed to evaluate the effects of a lyophilized pineapple extract titrated in bromelain (Brome-Inf®), and purified bro-melain on pain, swelling, trismus and quality…
View article: Improved Cardiovascular Effects of a Novel Pomegranate Byproduct Extract Obtained through Hydrodynamic Cavitation
Improved Cardiovascular Effects of a Novel Pomegranate Byproduct Extract Obtained through Hydrodynamic Cavitation Open
The healthy properties of pomegranate fruit, a highly consumed food, have been known for a long time. However, the pomegranate supply chain is still rather inefficient, with the non-edible fraction, whose weight is roughly half the total a…
View article: Isothiocyanate-Corticosteroid Conjugates Against Asthma: Unity Makes Strength
Isothiocyanate-Corticosteroid Conjugates Against Asthma: Unity Makes Strength Open
View article: Design, Synthesis and Biological Evaluation of New Rivastigmine Derivatives as Neuroprotective Molecules
Design, Synthesis and Biological Evaluation of New Rivastigmine Derivatives as Neuroprotective Molecules Open
View article: Erucin Exerts Cardioprotective Effects on Ischemia/Reperfusion Injury through the Modulation of mitoKATP Channels
Erucin Exerts Cardioprotective Effects on Ischemia/Reperfusion Injury through the Modulation of mitoKATP Channels Open
Modulation of mitochondrial K channels represents a pharmacological strategy to promote cardioprotective effects. Isothiocyanates emerge as molecules capable of releasing hydrogen sulfide (H2S), an endogenous pleiotropic gasotransmitter re…
View article: Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying <i>in vivo</i> cardioprotective activities
Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying <i>in vivo</i> cardioprotective activities Open
Sirtuin 1 (SIRT1) is an enzyme that relies on NAD + cofactor and functions as a deacetylase.
View article: Anti-Proliferative Properties of the Novel Hybrid Drug Met-ITC, Composed of the Native Drug Metformin with the Addition of an Isothiocyanate H2S Donor Moiety, in Different Cancer Cell Lines
Anti-Proliferative Properties of the Novel Hybrid Drug Met-ITC, Composed of the Native Drug Metformin with the Addition of an Isothiocyanate H2S Donor Moiety, in Different Cancer Cell Lines Open
Metformin (Met) is the first-line therapy in type 2 diabetes mellitus but, in last few years, it has also been evaluated as anti-cancer agent. Several pathways, such as AMPK or PI3K/Akt/mTOR, are likely to be involved in the anti-cancer Me…
View article: Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: Classification, differences and relevance in preclinical and clinical studies
Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: Classification, differences and relevance in preclinical and clinical studies Open
Hydrogen sulfide (H2S) has been extensively studied as a signal molecule in the body for the past 30 years. Researchers have conducted studies using both natural and synthetic sources of H2S, known as H2S d…