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View article: Experimental evolution of Plasmodium yoelii in single and helminth-coinfected mice
Experimental evolution of Plasmodium yoelii in single and helminth-coinfected mice Open
Background Coinfection has the potential to affect key traits describing the infection dynamics, the severity of the disease and in fine parasite fitness. However, despite its pervasiveness, experimental work investigating how parasites ad…
View article: Disease severity in coinfected hosts: the importance of infection order
Disease severity in coinfected hosts: the importance of infection order Open
When hosts are simultaneously infected by different pathogens, the severity of the disease might be altered compared to hosts harboring single infections. The reasons underlying these changes in parasite virulence are manifold. Here, we in…
View article: Coinfection with malaria alters the dynamics and fitness of an intestinal nematode
Coinfection with malaria alters the dynamics and fitness of an intestinal nematode Open
Infections with soil transmitted helminths (STHs) are highly prevalent in humans living in the intertropical region. While, in most cases, STHs can establish chronic infections, the dynamics of the infection can be altered when other paras…
View article: Disease severity in coinfected hosts: the importance of infection order
Disease severity in coinfected hosts: the importance of infection order Open
When hosts are simultaneously infected by different pathogens, the severity of the disease might be altered compared to hosts harboring single infections. The reasons underlying these changes in parasite virulence are manifold. Here, we in…
View article: Activation of TLRs Triggers GLP-1 Secretion in Mice
Activation of TLRs Triggers GLP-1 Secretion in Mice Open
The gastrointestinal tract constitutes a large interface with the inner body and is a crucial barrier against gut microbiota and other pathogens. As soon as this barrier is damaged, pathogen-associated molecular patterns (PAMPs) are recogn…
View article: Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS
Increased Weight Gain and Insulin Resistance in HF-Fed PLTP Deficient Mice Is Related to Altered Inflammatory Response and Plasma Transport of Gut-Derived LPS Open
Bacterial lipopolysaccharides (LPS, endotoxins) are found in high amounts in the gut lumen. LPS can cross the gut barrier and pass into the blood (endotoxemia), leading to low-grade inflammation, a common scheme in metabolic diseases. Phos…
View article: Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein
Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein Open
Introduction During peritonitis, lipopolysaccharides (LPS) cross the peritoneum and pass through the liver before reaching the central compartment. The aim of the present study was to investigate the role of lipoproteins and phospholipid t…
View article: Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis Open
Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a pivotal role in cell homeostasis, but its contribution to macrophage functions and host defense remains to be delineated. Here, we showed that lipopol…