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View article: Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells
Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide. An initial response to chemotherapy, such as gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed b…
View article: Targeted Nanoencapsulation of Tunicamycin Reduces Toxicity While Improving its Therapeutic Effectiveness in Pancreatic Cancer Cells
Targeted Nanoencapsulation of Tunicamycin Reduces Toxicity While Improving its Therapeutic Effectiveness in Pancreatic Cancer Cells Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide. An initial response to chemotherapy, such as Gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed b…
View article: Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets
Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets Open
Background: Ovarian cancer (OC), the most lethal gynecologic malignancy, is highly resistant to current treatment strategies. High-grade serous epithelial ovarian cancer (HGSOC) cells with increased somatic mutations and genomic instabilit…
View article: <i>Emblica officinalis</i>extract downregulates pro-angiogenic molecules<i>via</i>upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
<i>Emblica officinalis</i>extract downregulates pro-angiogenic molecules<i>via</i>upregulation of cellular and exosomal miR-375 in human ovarian cancer cells Open
Ovarian cancer (OC) is highly resistant to current treatment strategies based on a combination of surgery, chemotherapy and radiation therapy. We have recently demonstrated the anti-neoplastic effect of Amla extract (Emblica officinalis, A…
View article: Down-regulation of placental neuropilin-1 in fetal growth restriction
Down-regulation of placental neuropilin-1 in fetal growth restriction Open
The study demonstrated significant down-regulation of placental NRP-1 expression in FGR pregnancies complicated with AEDF in umbilical artery. As NRP-1 is known to promote sprouting angiogenesis, its down-regulation may be involved in the …