Alon D. Levin
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Benzimidazoles Promote Anti-TNF Mediated Induction of Regulatory Macrophages and Enhance Therapeutic Efficacy in a Murine Model Open
Albendazole enhances the induction of regulatory macrophages by anti-TNF and potentiates clinical efficacy in murine colitis. Given its favourable safety profile, these data indicate that the repurposing of albendazole may be a novel optio…
DOP036 The therapeutic efficacy of anti-TNF requires Fc-gamma receptors and can be improved by antibody hypo-fucosylation Open
Background: Treatment with the IgG1 anti-TNF antibodies infliximab and adalimumab achieves complete mucosal healing in a considerable proportion of patients with Crohn's disease. In contrast, the Fab' fragment certolizumab showed only 4% e…
View article: Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease
Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease Open
Several anti-tumour necrosis factor [TNF] blocking strategies have been evaluated in patients with Crohn's disease. Compounds that have been tested included the full monoclonal IgG1 antibodies infliximab and adalimumab, the pegylated anti-…