Alparslan Asan
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View article: Chemoproteomic analysis reveals RECQL4 as a mediator of nitroalkene-dependent double-strand break repair inhibition in cancer.
Chemoproteomic analysis reveals RECQL4 as a mediator of nitroalkene-dependent double-strand break repair inhibition in cancer. Open
View article: Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies Open
View article: Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies Open
Nitro fatty acids (NO 2 -FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species. NO 2 -FAs undergo rever…
View article: Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1
Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1 Open
RAD51 is a critical recombinase that functions in concert with auxiliary mediator proteins to direct the homologous recombination (HR) DNA repair pathway. We show that Cys319 RAD51 possesses nucleophilic characteristics and is important fo…
View article: Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer Open
View article: Nitroalkene Repression of Homologous Recombination as a Treatment for Triple Negative Breast Cancer
Nitroalkene Repression of Homologous Recombination as a Treatment for Triple Negative Breast Cancer Open
Triple-negative breast cancer (TNBC) is a heterogenous disease accounting for ~20% of all breast cancer (BC) cases. It is characterized by high genomic instability making it an aggressive BC subtype with higher rates of metastatic disease …
View article: Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells
Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells Open
Homologous recombination (HR)-directed DNA double-strand break (DSB) repair enables template-directed DNA repair to maintain genomic stability. RAD51 recombinase (RAD51) is a critical component of HR and facilitates DNA strand exchange in …
View article: Redox Regulation of RAD51 and Homologous Recombination by Peroxiredoxin 1 and Electrophilic Nitro-Fatty Acids
Redox Regulation of RAD51 and Homologous Recombination by Peroxiredoxin 1 and Electrophilic Nitro-Fatty Acids Open
View article: Correction: Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes
Correction: Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes Open
[This corrects the article DOI: 10.1371/journal.pgen.1005950.].
View article: Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth
Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth Open
Administration protocols of rNRG1 for stimulating cardiac regeneration in mice during the first month of life did not induce unwanted growth effects. Further studies may be required to determine whether this is the case in a corresponding …
View article: Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes
Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes Open
Genetic and molecular studies have provided considerable insight into how various tissue progenitors are specified in early embryogenesis, but much less is known about how those progenitors create three-dimensional tissues and organs. The …