Altaf Ali Laghari
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View article: SURG-06. Treatment Outcomes Of Hydrocephalus Management Strategies In Patients With Cerebellopontine Angle Lesions
SURG-06. Treatment Outcomes Of Hydrocephalus Management Strategies In Patients With Cerebellopontine Angle Lesions Open
INTRODUCTION Approximately 3.7–42% of cerebellopontine angle (CPA) lesions may present with symptomatic or asymptomatic Hydrocephalus (HCP), often due to cerebrospinal fluid blockage at the fourth ventricle. The optimal management strategy…
View article: miR-21 as a Diagnostic and Prognostic Biomarker in Glioma: Tissue and Serum Expression Analysis in a Pakistani Cohort
miR-21 as a Diagnostic and Prognostic Biomarker in Glioma: Tissue and Serum Expression Analysis in a Pakistani Cohort Open
Background Gliomas are heterogeneous primary brain tumors with a poor prognosis, particularly in higher grades. MicroRNA-21 (miR-21) has emerged as a potential oncogenic biomarker in various cancers, including gliomas; however, its clinica…
View article: Clinical and Molecular Characterization of Glioma Patients: miR-21 Expression as a Prognostic Biomarker in Tissue and Serum
Clinical and Molecular Characterization of Glioma Patients: miR-21 Expression as a Prognostic Biomarker in Tissue and Serum Open
Background Glioma remains challenging due to high recurrence rates and resistance to treatment. Diagnosis and follow-up in resource-constrained regions often leads to significant patient attrition. Serum microRNA (miRNA) expression profile…
View article: BIOM-33. INVESTIGATING MIR-21 AS A NON-INVASIVE PROGNOSTIC BIOMARKER IN GLIOMA PATIENTS IN RESOURCE CONSTRAINT SETTINGS
BIOM-33. INVESTIGATING MIR-21 AS A NON-INVASIVE PROGNOSTIC BIOMARKER IN GLIOMA PATIENTS IN RESOURCE CONSTRAINT SETTINGS Open
BACKGROUND Glioma treatment remains challenging due to high recurrence rates and resistance to treatment. Diagnosis and follow-up in resource-constrained regions often leads to significant patient attrition. Serum microRNA (miRNA) expressi…
View article: Autophagy-associated biomarkers ULK2, UVRAG, and miRNAs miR-21, miR-126, and miR-374: Prognostic significance in glioma patients
Autophagy-associated biomarkers ULK2, UVRAG, and miRNAs miR-21, miR-126, and miR-374: Prognostic significance in glioma patients Open
As the pioneering study from Pakistan, our research distinctly focuses on validating the roles of autophagy-associated genes and MicroRNAs (miRs) in the unique context of our population for glioma prognosis. The study delves into the nuanc…
View article: Invasive pituitary adenoma presenting with cerebrospinal fluid rhinorrhea and meningitis – A case report
Invasive pituitary adenoma presenting with cerebrospinal fluid rhinorrhea and meningitis – A case report Open
Background: Most pituitary neuroendocrine tumors are benign, except some adenomas that show invasiveness and are called invasive pituitary adenomas. These are challenging and rare pathologies. Case Description: We present a case of a 40-ye…
View article: AB062. Investigating miR-21 as a non-invasive prognostic biomarker in glioma patients
AB062. Investigating miR-21 as a non-invasive prognostic biomarker in glioma patients Open
Our findings validate the utility of miR-21 as a prognostic serum biomarker to help diagnose and assess treatment response in advancing glioma grades, within our population.
View article: AB059. Molecular signatures for survival prediction in glioma: a prospective, real-world data analysis
AB059. Molecular signatures for survival prediction in glioma: a prospective, real-world data analysis Open
In our cohort, the revised World Health Organization (WHO) classification shows significant implications on prognosis and implications for treatment. Although these markers are not commonly used in low-and-middle-income country centers, ou…
View article: FREQUENCY OF LOW BACK PAIN AND ITS IMPACT ON MEDICAL STUDENTS OF BILAWAL MEDICAL COLLEGE: A RETROSPECTIVE SURVEY
FREQUENCY OF LOW BACK PAIN AND ITS IMPACT ON MEDICAL STUDENTS OF BILAWAL MEDICAL COLLEGE: A RETROSPECTIVE SURVEY Open
Low back pain (LBP) is a significant health and economic problem among populations in high-resource countries. LBP is one of the prevalent complaints among all age groups. Objective: To assess the frequency of low back pain (LBP) among med…
View article: Comparative Analysis of Surgical Site Infections in Pediatric Brain Tumor Patients: Hygiene Practices, Risk Factors, and Implications for Healthcare Costs and Mortality
Comparative Analysis of Surgical Site Infections in Pediatric Brain Tumor Patients: Hygiene Practices, Risk Factors, and Implications for Healthcare Costs and Mortality Open
Surgical site infections (SSIs) significantly impact pediatric central nervous system tumor outcomes. We present our data of SSIs and their influence on outcomes of pediatric brain tumor patients treated between January 2011 till December …
View article: Capacity building for pediatric neuro-oncology in Pakistan- a project by my child matters program of Foundation S
Capacity building for pediatric neuro-oncology in Pakistan- a project by my child matters program of Foundation S Open
Introduction Initiated in June 2019, this collaborative effort involved 15 public and private sector hospitals in Pakistan. The primary objective was to enhance the capacity for pediatric neuro-oncology (PNO) care, supported by a My Child …
View article: Autophagy-Associated Markers LC3-II, ULK2 and microRNAs miR-21, miR-126 and miR-374 as a Potential Prognostic Indicator for Glioma Patients
Autophagy-Associated Markers LC3-II, ULK2 and microRNAs miR-21, miR-126 and miR-374 as a Potential Prognostic Indicator for Glioma Patients Open
Autophagy has a dual role in gliomagenesis in a microRNA modulated environment. We investigated the potential relevance of autophagy in glioma development and survival by exploring the association of autophagy-associated genes and microRNA…
View article: Autophagy-Associated Markers LC3-II, ULK2 and microRNAs miR-21, miR-126 and miR-374 as a Potential Prognostic Indicator for Glioma Patients
Autophagy-Associated Markers LC3-II, ULK2 and microRNAs miR-21, miR-126 and miR-374 as a Potential Prognostic Indicator for Glioma Patients Open
Autophagy has a dual role in gliomagenesis in a microRNA-modulated environment. We investigated the potential relevance of autophagy in glioma development and survival by exploring the association of autophagy-associated genes and microRNA…
View article: Pediatric Craniopharyngioma: A 20-year study on epidemiological features, clinical presentation, and survival outcomes in a tertiary care center from LMIC
Pediatric Craniopharyngioma: A 20-year study on epidemiological features, clinical presentation, and survival outcomes in a tertiary care center from LMIC Open
Introduction : Craniopharyngioma constitutes approximately 10% of primary brain tumors in children. It can cause considerable morbidity and mortality due to the local aggressiveness of the tumor itself or its management affecting the hypot…
View article: Tailoring of neurosurgical practice during COVID-19 in a developing country: Insights gained and a way forward
Tailoring of neurosurgical practice during COVID-19 in a developing country: Insights gained and a way forward Open
Background: The coronavirus disease-19 pandemic has aggravated the already neglected neurosurgical specialty in developing countries with a mounting shortage of specialists, long queues of operative patients, and a lack of adequate critica…
View article: Ten-year institutional review of infratentorial pediatric brain tumors from LMIC
Ten-year institutional review of infratentorial pediatric brain tumors from LMIC Open
PURPOSE: Brain tumors constitute 15–20% of all childhood cancers, whereas infratentorial brain tumors make up around 60–75% of all intracranial tumors. Surgical resection of infratentorial pediatric brain tumors carries a cumulative morbid…
View article: Treatment patterns of glioma in Pakistan: An epidemiological perspective
Treatment patterns of glioma in Pakistan: An epidemiological perspective Open
Objective: To define the landscape of treatment patterns and current epidemiological data regarding gliomas in Pakistan.
Methods: As part of the Pakistan Brain Tumour Epidemiology Study (PBTES), data were collected from 32 neurosurgical c…
View article: Private vs public care for intracranial tumours: Findings from Pakistan
Private vs public care for intracranial tumours: Findings from Pakistan Open
Objective: To observe the patient characteristics and centres providing neuro-oncological care in public and private health hospitals in Pakistan.
Methods: The Pakistan Association of Neuro-oncology carried out a retrospective, cross-sect…
View article: Craniopharyngioma: A lower-middle-income-country epidemiology
Craniopharyngioma: A lower-middle-income-country epidemiology Open
Objective: To quantify the frequency of craniopharyngiomas presenting to tertiary care neurosurgical centres, the demographics and mortality rate, and commonly presenting to neurosurgical practice. Methods: Our study was a retrospective cr…
View article: The Pakistan Brain Tumour Epidemiology Study
The Pakistan Brain Tumour Epidemiology Study Open
Objective: To provide information about brain tumour epidemiology in Pakistan and potential associated risk factors due to family, medical and social characteristics.
Methods: A retrospective cross-sectional nationwide study was designed …
View article: Gender disparities in brain tumours: A Pakistan brain tumour epidemiology study analysis
Gender disparities in brain tumours: A Pakistan brain tumour epidemiology study analysis Open
Objective: To explore the differences in demographic, surgical, and prognostic characteristics between the two genders in patients with brain tumours in Pakistan.
Methods: This study was a retrospective cross-sectional analysis of patient…
View article: Prioritizing Pituitary Adenoma Care apart from Pakistan: Analysis from an Epidemiological Study
Prioritizing Pituitary Adenoma Care apart from Pakistan: Analysis from an Epidemiological Study Open
Objective: To identify symptoms and risk factors and promptly diagnose, treat, and manage pituitary adenomas. Prioritizing care for pituitary adenomas will reduce the prolonged disability.
Methods: Patients with a histopathological diagno…
View article: Metastatic brain tumours in Pakistan: An epidemiological overview
Metastatic brain tumours in Pakistan: An epidemiological overview Open
Objective: To quantify the metastatic brain tumour burden presenting to tertiary care neurosurgical centres, the demographics and mortality rate, and the type of metastatic tumours commonly presenting to neurosurgical practice.
Methods: A…
View article: Factors associated with lost to follow up in patients with brain tumours: A multi-centre study in Pakistan
Factors associated with lost to follow up in patients with brain tumours: A multi-centre study in Pakistan Open
Objective: To identify populations at risk for lost to follow-up while undergoing management of brain tumours in a low-resource setting.
Methods: A retrospective study was conducted at the neurosurgical centre on patients presenting with …
View article: Time to surgery after radiological diagnosis of brain tumours in Pakistan: A nationwide cross-sectional study
Time to surgery after radiological diagnosis of brain tumours in Pakistan: A nationwide cross-sectional study Open
Objective: To investigate waiting times for brain tumour surgery in Pakistan from a nationwide sample and highlight specific affected patient populations.
Methods: A nationwide study was conducted as part of the Pakistan Brain Tumour Epid…
View article: A national overview of paediatric and adolescent and young adult surgical neuro-oncology in Pakistan
A national overview of paediatric and adolescent and young adult surgical neuro-oncology in Pakistan Open
Objective: To build a comprehensive brain tumour database that will allow us to analyse in detail the prevalence, demographics, and outcomes of the disease in paediatric, adolescent, and young adult age groups.
Method: A national cross-se…
View article: Ependymoma: an epidemiological perspective from a low- and middle-income country
Ependymoma: an epidemiological perspective from a low- and middle-income country Open
Objective: To enumerate the burden of ependymoma in our region and identify the demographic, tumoural, surgical, clinical characteristics, and outcomes of patients diagnosed with ependymoma.
Methods: This retrospective cross-sectional stu…
View article: Conducting the Pakistan brain tumour epidemiology study - report on the methodology
Conducting the Pakistan brain tumour epidemiology study - report on the methodology Open
Objective: To combat the lack of brain tumour registries, the Pakistan Brain Tumour Epidemiology Study (PBTES) was conducted without any funding from an external source.
Methods: A retrospective analysis of patient data, including patient…