Alva M. Casey
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View article: An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice Open
Impaired mitochondrial bioenergetics in macrophages promotes hyperinflammatory cytokine responses, but whether inherited mtDNA mutations drive similar phenotypes is unknown. Here, we profiled macrophages harbouring a heteroplasmic mitochon…
View article: Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation Open
Macrophages stimulated by lipopolysaccharide (LPS) generate mitochondria-derived reactive oxygen species (mtROS) that act as antimicrobial agents and redox signals; however, the mechanism of LPS-induced mitochondrial superoxide generation …
View article: Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation Open
View article: Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation Open
View article: An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i>
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i> Open
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses 1–6 , but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this question using a multi-omic approac…
View article: Mitochondrial complex I activity in microglia sustains neuroinflammation
Mitochondrial complex I activity in microglia sustains neuroinflammation Open
Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis 1 . Distinct metabolic and mitochondrial features guide the activation and the div…
View article: Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance
Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance Open
Ischemic stroke results in a loss of tissue homeostasis and integrity, the underlying pathobiology of which stems primarily from the depletion of cellular energy stores and perturbation of available metabolites 1 . Hibernation in thirteen-…
View article: Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Open
View article: Uncovering the source of mitochondrial superoxide in pro-inflammatory macrophages: Insights from immunometabolism
Uncovering the source of mitochondrial superoxide in pro-inflammatory macrophages: Insights from immunometabolism Open
View article: Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury
Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury Open
Cell models of cardiac ischemia-reperfusion (IR) injury are essential to facilitate understanding, but current monolayer cell models poorly replicate the in vivo IR injury that occurs within a three-dimensional tissue. Here we show that th…
View article: Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response Open
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protei…
View article: Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response
Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response Open
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved networks of cytoprotective proteins controlled by nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator the Kelch-like ECH assoc…
View article: Nrf2 is a Central Regulator of the Metabolic Landscape in Macrophages and Finetunes Their Inflammatory Response
Nrf2 is a Central Regulator of the Metabolic Landscape in Macrophages and Finetunes Their Inflammatory Response Open