Álvaro Pascual‐Leone
YOU?
Author Swipe
View article: The Healthy Aging Initiative (HAI): an interdisciplinary longitudinal cohort study to characterize and promote healthspan in senior housing
The Healthy Aging Initiative (HAI): an interdisciplinary longitudinal cohort study to characterize and promote healthspan in senior housing Open
Objective We present the rationale, design, and methods for the Healthy Aging Initiative (HAI), a prospective longitudinal cohort study of older adults primarily residing in senior housing, aimed to identify and characterize factors associ…
View article: Increasing resilience to stress by home-based transcranial stimulation
Increasing resilience to stress by home-based transcranial stimulation Open
Mental health disorders, especially anxiety and depression, affect nearly one billion people worldwide, with chronic stress playing a major role in their onset and severity. Despite growing demand, access to care remains limited, underscor…
View article: Sex differences in healthy brain aging are unlikely to explain higher Alzheimer’s disease prevalence in women
Sex differences in healthy brain aging are unlikely to explain higher Alzheimer’s disease prevalence in women Open
As Alzheimer’s disease (AD) is diagnosed more frequently in women, understanding the role of sex has become a key priority in AD research. However, despite aging being the primary risk factor for AD, it remains unclear whether men and wome…
View article: EEG Biomarkers for a Precision-Medicine Approach to Noninvasive Brain Stimulation for Major Depressive Disorder
EEG Biomarkers for a Precision-Medicine Approach to Noninvasive Brain Stimulation for Major Depressive Disorder Open
View article: Complexity of Resting Cortical Activity Predicts Neurophysiological Responses to Theta- Burst Stimulation but Fails to Generalize: A Rigorous Machine-Learning Approach
Complexity of Resting Cortical Activity Predicts Neurophysiological Responses to Theta- Burst Stimulation but Fails to Generalize: A Rigorous Machine-Learning Approach Open
View article: Sensory Entrained TMS (seTMS) enhances motor cortex plasticity
Sensory Entrained TMS (seTMS) enhances motor cortex plasticity Open
Neural excitability fluctuates with sensory events, creating windows of opportunity to enhance brain stimulation. Repetitive transcranial magnetic stimulation (TMS), including intermittent theta burst stimulation (iTBS), is a promising tre…
View article: Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance
Clustering on longitudinal lifestyle trajectories and their impact on cognitive performance Open
Introduction Lifestyle factors have demonstrated a significant contribution to resilience against cognitive decline and age-related diseases. However, the understanding of how combinations of modifiable lifestyle behaviors relate to cognit…
View article: Concurrent Detection of Cognitive Impairment and Amyloid Positivity with a Next-Generation Digital Cognitive Assessment
Concurrent Detection of Cognitive Impairment and Amyloid Positivity with a Next-Generation Digital Cognitive Assessment Open
Background: Early identification of cognitive impairment andbrain pathology associated with Alzheimer’s disease (AD) is essential to maximize benefits from lifestyle interventions and emerging pharmacologic disease-modifying treatments (DM…
View article: Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes
Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes Open
Differences in the volumes of brain structures between individuals are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains unclear to what extent these differences…
View article: Transcranial Pulsed Current Stimulation and Social Functioning in Children With Autism
Transcranial Pulsed Current Stimulation and Social Functioning in Children With Autism Open
Importance Transcranial pulsed current stimulation (tPCS) may improve social functioning and sleep disorders in children with autism spectrum disorder (ASD). Prior trials have been limited by small sample sizes, single-center designs, and …
View article: Incorporating individually defined brain health priorities in clinical trial outcomes: the electronic Person‐Specific Outcome Measure approach in the United States
Incorporating individually defined brain health priorities in clinical trial outcomes: the electronic Person‐Specific Outcome Measure approach in the United States Open
INTRODUCTION While a limited number of disease‐modifying treatments for Alzheimer's disease (AD) have been approved in the United States, there is caution in adopting these treatments in clinical use. The electronic Person‐Specific Outcome…
View article: Vulnerability to memory decline in aging. A mega-analysis of structural brain change.
Vulnerability to memory decline in aging. A mega-analysis of structural brain change. Open
Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leveraged 13 longitudinal datasets, including 3,737 cognitively healthy adults (10,3…
View article: Type 2 diabetes and late-onset Alzheimer’s disease and related dementia: A longitudinal cohort study integrating polygenic risk score
Type 2 diabetes and late-onset Alzheimer’s disease and related dementia: A longitudinal cohort study integrating polygenic risk score Open
Background The inherent genetic effects were not established between type 2 diabetes (T2DM) and Alzheimer's disease and related dementia (ADRD). Objective We aimed to investigate the association between T2DM and ADRD by integrating T2DM po…
View article: Big non-invasive brain stimulation data (Big NIBS data): an open-access platform and repository for NIBS data
Big non-invasive brain stimulation data (Big NIBS data): an open-access platform and repository for NIBS data Open
Non-invasive brain stimulation (NIBS) is a widely used technique in research and clinical settings, capable of both measuring the activity of the nervous system and treating the symptoms of brain disorders. Unlike other fields of neuroscie…
View article: Big non-invasive brain stimulation data (Big NIBS data): An open-access platform and repository for NIBS data
Big non-invasive brain stimulation data (Big NIBS data): An open-access platform and repository for NIBS data Open
View article: Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries
Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries Open
View article: Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries
Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries Open
Why education is linked to higher cognitive function in aging is fiercely debated. Leading theories propose that education reduces brain decline in aging, enhances tolerance to brain pathology, or that it does not affect cognitive decline …
View article: Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults
Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults Open
Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging heal…
View article: Associations between purpose in life, well-being, and TMS-EEG induced brain plasticity in cognitively preserved older adults
Associations between purpose in life, well-being, and TMS-EEG induced brain plasticity in cognitively preserved older adults Open
View article: Transcranial random noise stimulation and functional-electrical stimulation-assisted task-specific practice to improve upper extremity function after moderate-to-severe stroke: a pilot randomized clinical trial
Transcranial random noise stimulation and functional-electrical stimulation-assisted task-specific practice to improve upper extremity function after moderate-to-severe stroke: a pilot randomized clinical trial Open
View article: Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part II: Biophysics, Dosimetry, and Safety Recommendations
Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part II: Biophysics, Dosimetry, and Safety Recommendations Open
Temporal interference stimulation (TIS) is a new form of transcranial electrical stimulation (tES) that has been proposed as a method for targeted, noninvasive stimulation of deep brain structures. While TIS holds promise for a variety of …
View article: Transcranial Temporal Interference STN Stimulation Alleviates Motor Symptoms in Parkinson's Disease: A Pilot Randomized Controlled Study
Transcranial Temporal Interference STN Stimulation Alleviates Motor Symptoms in Parkinson's Disease: A Pilot Randomized Controlled Study Open
View article: Non-invasive prehabilitation before neurosurgery reconfigures the topology of language networks without compromising function
Non-invasive prehabilitation before neurosurgery reconfigures the topology of language networks without compromising function Open
View article: Assessing effects and test-retest reproducibility on TMS/EEG and behavior of the most commonly used repetitive transcranial stimulation protocols
Assessing effects and test-retest reproducibility on TMS/EEG and behavior of the most commonly used repetitive transcranial stimulation protocols Open
View article: TMS propagation explained in terms of connectivity patternsTMS propagation explained in terms of connectivity patterns
TMS propagation explained in terms of connectivity patternsTMS propagation explained in terms of connectivity patterns Open
View article: Transcranial magnetic stimulation as a therapeutic approach in mild cognitive impairment, Alzheimer’s disease, and related dementias: a systematic review and meta-analysis
Transcranial magnetic stimulation as a therapeutic approach in mild cognitive impairment, Alzheimer’s disease, and related dementias: a systematic review and meta-analysis Open
View article: Prefrontal tDCS for Smoking Cessation: Focus on the Number of Sessions and Motivation to Quit
Prefrontal tDCS for Smoking Cessation: Focus on the Number of Sessions and Motivation to Quit Open
Neuromodulation through transcranial direct current stimulation (tDCS) has a B recommendation for the treatment of addiction according to therapeutic evidence guidance. We present an intervention, with randomization and placebo, to test th…
View article: Big non-invasive brain stimulation data (Big NIBS data): an open-access platform and repository for NIBS data
Big non-invasive brain stimulation data (Big NIBS data): an open-access platform and repository for NIBS data Open
Non-invasive brain stimulation (NIBS) is a widely used technique in research and clinical settings, capable of both measuring the activity of the nervous system and treating the symptoms of brain disorders. Unlike other fields of neuroscie…
View article: Big non-invasive brain stimulation data (Big NIBS data): an open-access platform and repository for NIBS data
Big non-invasive brain stimulation data (Big NIBS data): an open-access platform and repository for NIBS data Open
Non-invasive brain stimulation (NIBS) is a widely used technique in research and clinical settings, capable of both measuring the activity of the nervous system and treating the symptoms of brain disorders. Unlike other fields of neuroscie…
View article: A measure of modifiable lifestyle factors shaping subjective cognitive reserve in the general population
A measure of modifiable lifestyle factors shaping subjective cognitive reserve in the general population Open
Objective This study examined the psychometric properties of a newly developed scale for measuring subjective cognitive reserve (SCR) across multiple domains, including nutrition, physical condition, sleep, cognition, willingness to learn,…