Álvaro Teijeira
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View article: 4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models
4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models Open
Background Ionizing radiation (IR) is a double-edged sword for immunotherapy as it may have both immunosuppressive and immunostimulatory effects. The biological effects of IR on the tumor microenvironment (TME) are a key factor for this ba…
View article: 781 4–1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models
781 4–1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models Open
View article: Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S2. Time-lapse confocal microscopy of co-cultures of tumor spheroids covered by radiation-induced NETs and cytotoxic lymphocytes. HT29 tumor cell-spheroids stained with CMRA (red) were cocultured or not with 2 Gy-irradi…
View article: Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S1. Autocrine IL-8 is secreted upon low-dose g-irradiation.
View article: Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Table S1. Description of the cohorts of patients undergoing radiotherapy.
View article: Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S2. Time-lapse confocal microscopy of co-cultures of tumor spheroids covered by radiation-induced NETs and cytotoxic lymphocytes. HT29 tumor cell-spheroids stained with CMRA (red) were cocultured or not with 2 Gy-irradi…
View article: Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S1. Autocrine IL-8 is secreted upon low-dose g-irradiation.
View article: Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Table S1. Description of the cohorts of patients undergoing radiotherapy.
View article: Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S2. Radiation-induced NETs increase metastases to the lung in a spontaneously metastatic model.
View article: Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Purpose:Patients with cancer frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in which polymorphonuclear leukocytes circulate. Following the observatio…
View article: Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S3. The serum protein thioredoxin blocks low-dose g-irradiation induced NETosis.
View article: Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S1. Time-lapse confocal microscopy showing the induction of NETosis by low-dose y-irradiation of human neutrophils. 3D reconstruction of a z-stack time-lapse acquisition of pre-stained neutrophils (red) treated with the…
View article: Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Purpose:Patients with cancer frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in which polymorphonuclear leukocytes circulate. Following the observatio…
View article: Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S3. The serum protein thioredoxin blocks low-dose g-irradiation induced NETosis.
View article: Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S2. Radiation-induced NETs increase metastases to the lung in a spontaneously metastatic model.
View article: Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S1. Time-lapse confocal microscopy showing the induction of NETosis by low-dose y-irradiation of human neutrophils. 3D reconstruction of a z-stack time-lapse acquisition of pre-stained neutrophils (red) treated with the…
View article: Short-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism
Short-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism Open
Biomarkers for cancer immunotherapy are an unmet medical need. The group of Daniela Thommen at the NKI recently reported on novel methodologies based on short-term cultures of patient-derived tumor fragments whose cytokine concentrations i…
View article: Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities
Spatially resolved tissue imaging to analyze the tumor immune microenvironment: beyond cell-type densities Open
Introduction The tissue immune microenvironment is associated with key aspects of tumor biology. The interaction between the immune system and cancer cells has predictive and prognostic potential across different tumor types. Spatially res…
View article: Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Purpose: Patients with cancer frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in which polymorphonuclear leukocytes circulate. Following the observati…
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View article: Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis
Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis Open
Background Peritoneal carcinomatosis is an advanced stage of cancer in which the disease has spread to the peritoneal cavity. In order to restore antitumor immunity subverted by tumor cells in this location, we evaluated intraperitoneal ad…
View article: Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming
Cytotoxicity as a form of immunogenic cell death leading to efficient tumor antigen cross‐priming Open
Summary Antigen cross‐priming of CD8 + T cells is a critical process necessary for the effective expansion and activation of CD8 + T cells endowed with the ability to recognize and destroy tumor cells. The cross‐presentation of tumor antig…
View article: Intratumoral co‐injection of <scp>NK</scp> cells and <scp>NKG2A</scp>‐neutralizing monoclonal antibodies
Intratumoral co‐injection of <span>NK</span> cells and <span>NKG2A</span>‐neutralizing monoclonal antibodies Open
View article: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects Open
CD137 (4-1BB) is a member of the TNFR family that mediates potent T cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies (mAbs). CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse model…
View article: Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists
Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists Open
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have co…
View article: Intratumoral injection of IL-12-encoding mRNA targeted to CSF1R and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure
Intratumoral injection of IL-12-encoding mRNA targeted to CSF1R and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure Open
View article: Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic Open
BO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-r…
View article: Supplementary Data from Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer
Supplementary Data from Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer Open
Supplementary Data from Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer
View article: Data from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
Data from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β Open
Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor response to checkpoint inhibitors and is known to chemoattract and activate immunosuppressive myeloid leukocytes. In human cancer, IL8 mRNA levels cor…
View article: Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β Open
Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β