Alycia G. Berman
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View article: Photocurable extracellular matrix sealant for cessation of venous hemorrhage
Photocurable extracellular matrix sealant for cessation of venous hemorrhage Open
Hemorrhage is the second leading cause of death in patients under 46 years of age in the United States. Cessation of hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling the bleed via direct pressure or tourniquet is often…
View article: Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice
Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice Open
Estrogen agonist raloxifene is an FDA-approved treatment of osteoporosis in postmenopausal women, which may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that 1) aging and biolog…
View article: Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition
Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition Open
View article: Nuclear deformation guides chromatin reorganization in cardiac development and disease
Nuclear deformation guides chromatin reorganization in cardiac development and disease Open
View article: Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement
Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement Open
View article: Raloxifene reduces sex- and age-related intervertebral disc degeneration in mice by estrogen signaling
Raloxifene reduces sex- and age-related intervertebral disc degeneration in mice by estrogen signaling Open
Estrogen agonist raloxifene is an FDA-approved treatment for osteoporosis in postmenopausal women that may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that raloxifene would aug…
View article: Effects of Raloxifene and tibial loading on bone mass and mechanics in male and female mice
Effects of Raloxifene and tibial loading on bone mass and mechanics in male and female mice Open
Purpose: Raloxifene (RAL) is a selective estrogen receptor modulator (SERM) that has previously been shown to cause acellular benefits to bone tissue. Due to these improvements, RAL was combined with targeted tibial loading to asses…
View article: 6′-Methoxy Raloxifene-analog enhances mouse bone properties with reduced estrogen receptor binding
6′-Methoxy Raloxifene-analog enhances mouse bone properties with reduced estrogen receptor binding Open
Raloxifene (RAL) is an FDA-approved drug used to treat osteoporosis in postmenopausal women. RAL suppresses bone loss primarily through its role as a selective estrogen receptor modulator (SERM). This hormonal estrogen therapy promotes uni…
View article: Muscle contraction induces osteogenic levels of cortical bone strain despite muscle weakness in a mouse model of Osteogenesis Imperfecta
Muscle contraction induces osteogenic levels of cortical bone strain despite muscle weakness in a mouse model of Osteogenesis Imperfecta Open
View article: High-frequency murine ultrasound provides enhanced metrics of BAPN-induced AAA growth
High-frequency murine ultrasound provides enhanced metrics of BAPN-induced AAA growth Open
An abdominal aortic aneurysm (AAA), defined as a pathological expansion of the largest artery in the abdomen, is a common vascular disease that frequently leads to death if rupture occurs. Once diagnosed, clinicians typically evaluate the …
View article: Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose
Simple minimally-invasive automatic antidote delivery device (A2D2) towards closed-loop reversal of opioid overdose Open
View article: Treadmill running and targeted tibial loading differentially improve bone mass in mice
Treadmill running and targeted tibial loading differentially improve bone mass in mice Open
View article: Supplementary Material for: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans
Supplementary Material for: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans Open
Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to lo…
View article: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans
Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans Open
Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to lo…
View article: Computational Fluid Dynamics of Vascular Disease in Animal Models
Computational Fluid Dynamics of Vascular Disease in Animal Models Open
Recent applications of computational fluid dynamics (CFD) applied to the cardiovascular system have demonstrated its power in investigating the impact of hemodynamics on disease initiation, progression, and treatment outcomes. Flow metrics…
View article: High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function
High-Frequency 4-Dimensional Ultrasound (4DUS): A Reliable Method for Assessing Murine Cardiac Function Open
In vivo imaging has provided a unique framework for studying pathological progression in various mouse models of cardiac disease. Although conventional short-axis motion-mode (SAX MM) ultrasound and cine magnetic resonance imaging (MRI) ar…
View article: Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy
Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy Open
View article: Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease
Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease Open
View article: Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice
Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice Open
The specifics of how the nanoscale properties of collagen (e.g., the crosslinking profile) affect the mechanical integrity of bone at larger length scales is poorly understood despite growing evidence that collagen's nanoscale properties a…
View article: Removing or truncating connexin 43 in murine osteocytes alters cortical geometry, nanoscale morphology, and tissue mechanics in the tibia
Removing or truncating connexin 43 in murine osteocytes alters cortical geometry, nanoscale morphology, and tissue mechanics in the tibia Open
View article: Differential effects of Epigallocatechin‐3‐gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model
Differential effects of Epigallocatechin‐3‐gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model Open
Scope Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is characterized by a spectrum of phenotypes including skeletal abnormalities. The Ts65Dn DS mouse model exhibits similar skeletal phenotypes as humans with DS. DY…
View article: Influence of mechanical stimulation on the quantity and quality of bone during modeling
Influence of mechanical stimulation on the quantity and quality of bone during modeling Open
View article: Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta
Raloxifene reduces skeletal fractures in an animal model of osteogenesis imperfecta Open
View article: Structural and Mechanical Improvements to Bone Are Strain Dependent with Axial Compression of the Tibia in Female C57BL/6 Mice
Structural and Mechanical Improvements to Bone Are Strain Dependent with Axial Compression of the Tibia in Female C57BL/6 Mice Open
Strain-induced adaption of bone has been well-studied in an axial loading model of the mouse tibia. However, most outcomes of these studies are restricted to changes in bone architecture and do not explore the mechanical implications of th…
View article: The Phosphate/Amide I ratio is Reduced by in vitro Glycation and may Correlate with Fracture Toughness
The Phosphate/Amide I ratio is Reduced by in vitro Glycation and may Correlate with Fracture Toughness Open