Alys R. Clark
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View article: Anatomical location and timing of deep venous thrombosis in pregnancy and the postpartum period: A narrative literature review.
Anatomical location and timing of deep venous thrombosis in pregnancy and the postpartum period: A narrative literature review. Open
View article: Vascular Remodelling in COPD: An In Silico Tool to Represent Pulmonary Haemodynamics in Obstructive Lung Disease
Vascular Remodelling in COPD: An In Silico Tool to Represent Pulmonary Haemodynamics in Obstructive Lung Disease Open
This model reproduces clinically measured mPAP and pulmonary vascular resistance values across COPD stages and quantifies how specific degrees of remodelling and pruning drive haemodynamic deterioration. This model provides a tool for hypo…
View article: Detailed microCT imaging protocol for ex vivo rat stomachs with comparative analysis
Detailed microCT imaging protocol for ex vivo rat stomachs with comparative analysis Open
Understanding gastric structure is essential for studying gastrointestinal disorders. While traditional histological analysis focuses on two dimensions, micro-computed tomography (μCT) offers high-resolution three-dimensional (3D) imaging …
View article: Mapping the variability of <i>in vivo</i> rat uterine electrical properties throughout the oestrous cycle
Mapping the variability of <i>in vivo</i> rat uterine electrical properties throughout the oestrous cycle Open
After reaching sexual maturity, uterine function is driven by cyclical variations in hormone levels. The electrical and mechanical activity in the uterus varies during the menstrual cycle, contributing to essential functions such as sperm …
View article: In Silico Modeling of Pulmonary Surfactant Dynamics From Alveolus to Whole Lung
In Silico Modeling of Pulmonary Surfactant Dynamics From Alveolus to Whole Lung Open
Surfactants play a crucial role in maintaining lung mechanics by reducing alveolar surface tension and preventing alveolar collapse. Deficiencies or alterations in surfactant properties can lead to significant changes in lung mechanics and…
View article: Electrical wave generation and spatial organization in uterine tissue
Electrical wave generation and spatial organization in uterine tissue Open
Healthy uterine function requires coordinated and spatially organized contractions over the menstrual cycle (oestrus in animals) and at term in pregnancy. The underlying mechanisms triggering and coordinating uterine contractions, without …
View article: Acute Cervical Vagus Nerve Stimulation Modulates Gastric Slow Waves in the Distal Rat Stomach
Acute Cervical Vagus Nerve Stimulation Modulates Gastric Slow Waves in the Distal Rat Stomach Open
Background Gastric motility is coordinated by bioelectrical events, named slow waves, which propagate across the stomach. Gastric dysrhythmias are associated with disorders of gut‐brain interaction. Electrical cervical vagus nerve stimulat…
View article: Reproducibility of a mathematical model of the neural regulation of phasic contractions and slow waves in the distal stomach
Reproducibility of a mathematical model of the neural regulation of phasic contractions and slow waves in the distal stomach Open
A mathematical model of neural regulation of distal gastric interstitial cells of Cajal and smooth muscle cells was developed by Athavale et al. (2023). The model incorporated five cellular mechanisms, of which four were inhibitory and one…
View article: Reproducibility of a mathematical model of the neural regulation of phasic contractions and slow waves in the distal stomach
Reproducibility of a mathematical model of the neural regulation of phasic contractions and slow waves in the distal stomach Open
A mathematical model of neural regulation of distal gastric interstitial cells of Cajal and smooth muscle cells was developed by Athavale et al. (2023). The model incorporated five cellular mechanisms, of which four were inhibitory and one…
View article: Feto-placental vascular structure and in silico haemodynamics: Of mice, rats, and human
Feto-placental vascular structure and in silico haemodynamics: Of mice, rats, and human Open
Pre-clinical placental research utilising rat and mouse placentae to understand the impact of feto-placental arborization on placental function and fetal development can inform the human context.
View article: Three‐dimensional virtual histology of the rat uterus musculature using micro‐computed tomography
Three‐dimensional virtual histology of the rat uterus musculature using micro‐computed tomography Open
Contractions of the uterus play an important role in menstruation and fertility, and contractile dysfunction can lead to chronic diseases such as endometriosis. However, the structure and function of the uterus are difficult to interrogate…
View article: Evaluating the role of sex-related structure-function differences on airway aerosol transport and deposition
Evaluating the role of sex-related structure-function differences on airway aerosol transport and deposition Open
Sex differences in airway tract particle deposition are analyzed using computational models that account for scale-specific structure and function. We show that sex-related differences in lung and airway size can explain experimental obser…
View article: Molecular regulators of defective placental and cardiovascular development in fetal growth restriction
Molecular regulators of defective placental and cardiovascular development in fetal growth restriction Open
Placental insufficiency is one of the major causes of fetal growth restriction (FGR), a significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. As well as the acute consequences of being born …
View article: Multichannel mapping of in vivo rat uterine myometrium exhibits both high and low frequency electrical activity in non-pregnancy
Multichannel mapping of in vivo rat uterine myometrium exhibits both high and low frequency electrical activity in non-pregnancy Open
The uterus exhibits intermittent electrophysiological activity in vivo. Although most active during labor, the non-pregnant uterus can exhibit activity of comparable magnitude to the early stages of labor. In this study, two types of flexi…
View article: 3D Single Vessel Fractional Moving Blood Volume (3D-svFMBV): Fully Automated Tissue Perfusion Estimation Using Ultrasound
3D Single Vessel Fractional Moving Blood Volume (3D-svFMBV): Fully Automated Tissue Perfusion Estimation Using Ultrasound Open
Power Doppler ultrasound (PD-US) is the ideal modality to assess tissue perfusion as it is cheap, patient-friendly and does not require ionizing radiation. However, meaningful inter-patient comparison only occurs if differences in tissue-a…
View article: Steady-state Approximations for Hodgkin-Huxley Cell Models: Towards Multi-scale Models of Uterine Smooth Muscle
Steady-state Approximations for Hodgkin-Huxley Cell Models: Towards Multi-scale Models of Uterine Smooth Muscle Open
The Tong, et al. 2011 publication presents a comprehensive mathematical model of electro- mechanical behaviour in a uterine smooth muscle cell. It incorporates ion channel currents into a classic Hodgkin-Huxley membrane voltage formulation…
View article: Steady-state Approximations for Hodgkin-Huxley Cell Models: Towards Multi-scale Models of Uterine Smooth Muscle
Steady-state Approximations for Hodgkin-Huxley Cell Models: Towards Multi-scale Models of Uterine Smooth Muscle Open
The Tong, et al. 2011 publication presents a comprehensive mathematical model of electro- mechanical behaviour in a uterine smooth muscle cell. It incorporates ion channel currents into a classic Hodgkin-Huxley membrane voltage formulation…
View article: Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model
Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model Open
Objective. Neural regulation of gastric motility occurs partly through the regulation of gastric bioelectrical slow waves (SWs) and phasic contractions. The interaction of the tissues and organs involved in this regulatory process is compl…
View article: Health information delivery to patients at risk of having a small for gestational age/growth restricted baby in Aotearoa New Zealand: what can we learn from lived experience?
Health information delivery to patients at risk of having a small for gestational age/growth restricted baby in Aotearoa New Zealand: what can we learn from lived experience? Open
Introduction: The importance of access to reliable information during pregnancy is heightened in pregnancy complications. Impaired fetal growth (including small for gestational age (SGA) and growth restricted (FGR) fetuses) affects up to 1…
View article: Multichannel mapping of in vivo rat uterine myometrium exhibits both high and low frequency electrical activity in non-pregnancy
Multichannel mapping of in vivo rat uterine myometrium exhibits both high and low frequency electrical activity in non-pregnancy Open
The uterus exhibits intermittent electrophysiological activity in vivo . Although most active during labor, the non-pregnant uterus can exhibit activity of comparable magnitude to the early stages of labor. In this study, two types of flex…
View article: Maternal Cardiovascular Responses to Position Change in Pregnancy
Maternal Cardiovascular Responses to Position Change in Pregnancy Open
The maternal cardiovascular-circulatory system undergoes profound changes almost from the conception of a pregnancy until the postpartum period to support the maternal adaptions required for pregnancy and lactation. Maintenance of cardiova…
View article: Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model
Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model Open
Multi-scale mathematical bioelectrical models of organs such as the uterus, stomach or heart present challenges both for accuracy and computational tractability. These multi-scale models are typically founded on models of biological cells …
View article: A review of feto-placental vasculature flow modelling
A review of feto-placental vasculature flow modelling Open
View article: Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and hemodynamic factors
Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and hemodynamic factors Open
Placenta-specific paracrine factors β-estradiol, progesterone, and placental growth factor attenuate flow-mediated constriction of the rate-limiting uterine radial arteries, enabling higher flow rates in pregnancy. These paracrine factors …
View article: The effect of maternal position on placental blood flow and fetoplacental oxygenation in late gestation fetal growth restriction: a magnetic resonance imaging study
The effect of maternal position on placental blood flow and fetoplacental oxygenation in late gestation fetal growth restriction: a magnetic resonance imaging study Open
Fetal growth restriction (FGR) and maternal supine going‐to‐sleep position are both risk factors for late stillbirth. This study aimed to use magnetic resonance imaging (MRI) to quantify the effect of maternal supine position on maternal‐p…
View article: A SCOPING REVIEW OF DIGITAL TECHNOLOGIES FOR WOMEN’S PELVIC FLOOR MUSCLE TRAINING TO MANAGE URINARY INCONTINENCE ACROSS THE LIFE COURSE.
A SCOPING REVIEW OF DIGITAL TECHNOLOGIES FOR WOMEN’S PELVIC FLOOR MUSCLE TRAINING TO MANAGE URINARY INCONTINENCE ACROSS THE LIFE COURSE. Open
View article: Digital Technologies for Women’s Pelvic Floor Muscle Training to Manage Urinary Incontinence Across Their Life Course: Scoping Review
Digital Technologies for Women’s Pelvic Floor Muscle Training to Manage Urinary Incontinence Across Their Life Course: Scoping Review Open
Background Women with urinary incontinence (UI) may consider using digital technologies (DTs) to guide pelvic floor muscle training (PFMT) to help manage their symptoms. DTs that deliver PFMT programs are readily available, yet uncertainty…
View article: The complexities of the human placenta
The complexities of the human placenta Open
The flow and transport of solute molecules in the intricate structure of the placenta make the organ a fetal life-support system.
View article: From fetus to neonate: A review of cardiovascular modeling in early life
From fetus to neonate: A review of cardiovascular modeling in early life Open
Computational modeling has well‐established utility in the study of cardiovascular hemodynamics, with applications in medical research and, increasingly, in clinical settings to improve the diagnosis and treatment of cardiovascular disease…
View article: Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years
Pulmonary vessel volume in idiopathic pulmonary fibrosis compared with healthy controls aged > 50 years Open
Idiopathic pulmonary fibrosis (IPF) is characterised by progressive fibrosing interstitial pneumonia with an associated irreversible decline in lung function and quality of life. IPF prevalence increases with age, appearing most frequently…