Alyssa M. McCoy
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View article: Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development
Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development Open
Members of the Sp family of transcription factors regulate gene expression via binding GC boxes within promoter regions. Unlike Sp1, which stimulates transcription, the closely related Sp3 can either repress or activate gene expression and…
View article: HA and M2 sequences alter the replication of 2013–16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures
HA and M2 sequences alter the replication of 2013–16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures Open
From 2013 to 2016, the H1N1 component of live, attenuated influenza vaccine (LAIV) performed very poorly in contrast to the inactivated influenza vaccine. We utilized a primary, differentiated human nasal epithelial cell (hNEC) culture sys…
View article: HA and M2 sequences alter the replication of 2013-16 H1 Live Attenuated Influenza Vaccine Infection in Human Nasal Epithelial Cell cultures
HA and M2 sequences alter the replication of 2013-16 H1 Live Attenuated Influenza Vaccine Infection in Human Nasal Epithelial Cell cultures Open
From 2013-2016, the H1N1 component of live, attenuated influenza vaccine (LAIV) performed very poorly in contrast to the inactivated influenza vaccine. We utilized a primary, differentiated human nasal epithelial (hNEC) culture system to a…
View article: Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection
Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection Open
View article: Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants
Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants Open
Lung macrophages mature after birth, placing newborn infants, particularly those born preterm, within a unique window of susceptibility to disease. We hypothesized that in preterm infants, lung macrophage immaturity contributes to the deve…
View article: The Mediating Role of Sleep in the Link between Attachment Styles and Conflict Styles in Romantic Relationships
The Mediating Role of Sleep in the Link between Attachment Styles and Conflict Styles in Romantic Relationships Open
The goal of this study was to examine if sleep quality (e.g., onset latency, efficiency, daytime sleepiness) mediates the links between insecure attachment styles and conflict communication styles (i.e., criticism, contempt, defensiveness,…
View article: Table of Contents
Table of Contents Open
View article: IKKβ Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis
IKKβ Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis Open
View article: IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development
IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development Open
Inflammation in the developing preterm lung leads to disrupted airway morphogenesis and chronic lung disease in human neonates. However, the molecular mechanisms linking inflammation and the pathways controlling airway morphogenesis remain…