Alyssa M. Pivirotto
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View article: Allele age estimators designed for whole-genome datasets show only a moderate reduction in performance when applied to whole-exome datasets
Allele age estimators designed for whole-genome datasets show only a moderate reduction in performance when applied to whole-exome datasets Open
As personalized genomics becomes more affordable, larger numbers of rare variants are being discovered, leading to important initiatives in identifying the functional impacts in relation to disease phenotypes. One way to characterize these…
View article: A New Comparative Framework for Estimating Selection on Synonymous Substitutions
A New Comparative Framework for Estimating Selection on Synonymous Substitutions Open
Selection on synonymous codon usage is a well-known and widespread phenomenon, yet existing models often do not account for it or its effect on synonymous substitution rates. In this article, we develop and expand the capabilities of multi…
View article: A new comparative framework for estimating selection on synonymous substitutions
A new comparative framework for estimating selection on synonymous substitutions Open
Selection on synonymous codon usage is a well known and widespread phenomenon, yet existing models often do not account for it or its effect on synonymous substitution rates. In this article, we develop and expand the capabilities of Multi…
View article: Allele age estimators designed for whole genome datasets show only a moderate reduction in performance when applied to whole exome datasets
Allele age estimators designed for whole genome datasets show only a moderate reduction in performance when applied to whole exome datasets Open
Personalized genomics in the healthcare system is becoming increasingly accessible as the costs of sequencing decreases. With the increase in the number of genomes, larger numbers of rare variants are being discovered, leading to important…
View article: Reviewer #2 (Public Review): Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls
Reviewer #2 (Public Review): Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls Open
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic variation in linked regions. However, despite this expectat…
View article: Reviewer #1 (Public Review): Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls
Reviewer #1 (Public Review): Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls Open
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic variation in linked regions. However, despite this expectat…
View article: Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls
Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls Open
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic variation in linked regions. However, despite this expectat…
View article: Reviewer #3 (Public Review): Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls
Reviewer #3 (Public Review): Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls Open
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic variation in linked regions. However, despite this expectat…
View article: Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls
Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls Open
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic variation in linked regions. However, despite this expectat…
View article: Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls
Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls Open
A classic population genetic prediction is that alleles experiencing directional selection should swiftly traverse allele frequency space, leaving detectable reductions in genetic variation in linked regions. However, despite this expectat…
View article: An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations
An estimator of first coalescent time reveals selection on young variants and large heterogeneity in rare allele ages among human populations Open
Allele age has long been a focus of population genetic research, primarily because it can be an important clue to the fitness effects of an allele. By virtue of their effects on fitness, alleles under directional selection are expected to …