Explanipedia

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking Open

Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding , et al. · 2021

Chemistry Biology

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor and mainstay therapeutic target for the treatment of type 2 diabetes and obesity. Recent reports have highlighted how biased agonism at the GLP-1R affect…

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1 Open

Amaara Marzook, Shiqian Chen, Philip Pickford, Maria Lucey, Yifan Wang , et al. · 2021

Biology Chemistry Medicine

The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of glucose homeostasis and has been successfully targeted for the treatment of type 2 diabetes. Recently described biased GLP-1R agonists with selective reductions in …

The Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells Open

Amaara Marzook, Alejandra Tomás, Ben Jones · 2021

Biology

The glucagon-like peptide 1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which mediates the effects of GLP-1, an incretin hormone secreted primarily from L-cells in the intestine and within the central nervous system. T…

Evaluation of efficacy-<i>versus</i>affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1 Open