Amal M. Sahyoun
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View article: The Role of Short-Chain Fatty Acids (SCFAs) in Colic and Anti-Inflammatory Pathways in Horses
The Role of Short-Chain Fatty Acids (SCFAs) in Colic and Anti-Inflammatory Pathways in Horses Open
Equine colic remains a prevalent and potentially life-threatening condition with multifactorial origins, including dietary imbalances, stress, and microbial dysbiosis. Central to equine gut health is the production of short-chain fatty aci…
View article: Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism
Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism Open
Bruxism is an involuntary condition involving grinding and clenching of the teeth, occurring during both wakefulness and sleep. This behavior can lead to various detrimental effects on oral health, including significant tooth wear and dama…
View article: The Impact of Absenteeism on Academic Performance Among First‐Year Dental Students
The Impact of Absenteeism on Academic Performance Among First‐Year Dental Students Open
Background According to the U.S. Department of Education, chronic absenteeism is a significant concern in health professions education which is characterized by missing 10% or more of school days that affect over 7 million students. This p…
View article: Exploring the relationship between periodontal diseases and osteoporosis: Potential role of butyrate
Exploring the relationship between periodontal diseases and osteoporosis: Potential role of butyrate Open
Osteoporosis, a condition marked by the loss of bone density and mass, affects individuals of all ages. However, it becomes more prevalent and severe with aging, increasing the risk of fractures and other health complications. Recent resea…
View article: Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review
Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review Open
The oral microbiome is a diverse ecosystem containing a community of symbiotic, commensal, and pathogenic microorganisms. One key microorganism linked to periodontal disease (PD) is Porphyromonas gingivalis (P. gingivalis), a Gram-negative…
View article: Unveiling four levansucrase enzymes: Insights into catalytic properties, kinetics, and end-product profiles
Unveiling four levansucrase enzymes: Insights into catalytic properties, kinetics, and end-product profiles Open
The biocatalytic approach based on Levansucrase (LS)-catalyzed transfructosylation reaction is of particular interest for the synthesis of well-defined FOSs and β-(2-6)-levan. The present study aims to characterize the catalytic properties…
View article: The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr−/− Mice with Obesity
The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr−/− Mice with Obesity Open
Objectives: Homozygous familial hypercholesteremia (HoFH) is a rare, life-threatening metabolic disease, mainly caused by a mutation in the LDL receptor. If untreated, HoFH causes premature death from acute coronary syndrome. Lomitapide is…
View article: Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2
Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2 Open
Objectives: Short-chain fatty acids (SCFAs), the main metabolites released from the gut microbiota, are altered during hypertension and obesity. SCFAs play a beneficial role in the cardiovascular system. However, the effect of SCFAs on cer…
View article: The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity
The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity Open
Objective In this study, the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity was investigated. Methods Eight‐week‐old C57BL/6 mice were fed with high‐fat diet for 12 wee…
View article: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy Open