Amalie C. M. Couch
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View article: Structural Magnetic Resonance Imaging and Genome-Wide Transcriptional Profiling Reveal Intergenerational Vulnerability in a Mouse Model of Preconceptional Stress
Structural Magnetic Resonance Imaging and Genome-Wide Transcriptional Profiling Reveal Intergenerational Vulnerability in a Mouse Model of Preconceptional Stress Open
Antenatal depression, affecting 10–20% of pregnancies worldwide, represents a major public health concern due to its association with maternal suicide, obstetric complications, and long-term neurodevelopmental and psychiatric vulnerability…
View article: Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study.
Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study. Open
Psychotic disorders such as schizophrenia (SZ) are associated with structural brain changes and increased cardiometabolic disease risk, potentially linked through shared inflammatory mechanisms. However, whether these associations reflect …
View article: Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study
Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study Open
Schizophrenia (SZ) is accompanied by structural brain alterations and elevated cardiometabolic risk, potentially linked through shared immune–metabolic mechanisms. To test for shared genetic underpinnings, we performed multi-trait colocali…
View article: Current Position and Future Direction of Inflammation in Neuropsychiatric Disorders
Current Position and Future Direction of Inflammation in Neuropsychiatric Disorders Open
Importance There has been a large increase in research focusing on inflammation across psychiatric disorders, with the hope of achieving breakthroughs seen with this approach in cancer and other conditions. Current findings suggest that im…
View article: Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study
Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study Open
View article: Transcriptional and cellular response of hiPSC-derived microglia-neural progenitor co-cultures exposed to IL-6
Transcriptional and cellular response of hiPSC-derived microglia-neural progenitor co-cultures exposed to IL-6 Open
Elevated interleukin (IL-)6 levels during prenatal development have been linked to increased risk for neurodevelopmental disorders (NDD) in the offspring, but the mechanism remains unclear. Human-induced pluripotent stem cell (hiPSC) model…
View article: Transcriptional and Cellular Response of hiPSC-derived Microglia-Neural Progenitor Co-Cultures Exposed to IL-6
Transcriptional and Cellular Response of hiPSC-derived Microglia-Neural Progenitor Co-Cultures Exposed to IL-6 Open
Elevated interleukin (IL-)6 levels during prenatal development have been linked to increased risk for neurodevelopmental disorders (NDD) in the offspring, but the mechanism remains unclear. Human-induced pluripotent stem cell (hiPSC) model…
View article: Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure
Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure Open
View article: Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells
Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells Open
View article: Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells
Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells Open
Background Exposure to elevated interleukin (IL)-6 levels in utero is consistently associated with increased risk for psychiatric disorders with a putative neurodevelopmental origin, such as schizophrenia (SZ) and autism spectrum condition…
View article: Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells
Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells Open
View article: Using human stem cell derived microglia and neural progenitor cells to model the effect of IL6 on early neurodevelopment
Using human stem cell derived microglia and neural progenitor cells to model the effect of IL6 on early neurodevelopment Open
View article: Maternal immune activation primes deficiencies in adult hippocampal neurogenesis
Maternal immune activation primes deficiencies in adult hippocampal neurogenesis Open
Neurogenesis, the process in which new neurons are generated, occurs throughout life in the mammalian hippocampus. Decreased adult hippocampal neurogenesis (AHN) is a common feature across psychiatric disorders, including schizophrenia, de…
View article: Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation
Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation Open
View article: Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes
Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes Open
Interferon-γ induces cellular and transcriptomic changes in human neural cells associated with neurodevelopmental disorders.
View article: Emerging Developments in Human Induced Pluripotent Stem Cell-Derived Microglia: Implications for Modelling Psychiatric Disorders With a Neurodevelopmental Origin
Emerging Developments in Human Induced Pluripotent Stem Cell-Derived Microglia: Implications for Modelling Psychiatric Disorders With a Neurodevelopmental Origin Open
Microglia, the resident tissue macrophages of the brain, are increasingly implicated in the pathophysiology of psychiatric disorders with a neurodevelopmental origin, including schizophrenia. To date, however, our understanding of the pote…
View article: Genome-scale identification of cellular pathways required for cell surface recognition
Genome-scale identification of cellular pathways required for cell surface recognition Open
Interactions mediated by cell surface receptors initiate important instructive signaling cues but can be difficult to detect in biochemical assays because they are often highly transient and membrane-embedded receptors are difficult to sol…