Ali A. Rizvi
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View article: Role of rosiglitazone in experimental Wistar rats model of neurodegeneration: Effect of peroxisome proliferator-activated receptors-γ as advanced glycation endproducts receptor of advanced glycation endproducts axis inhibitor
Role of rosiglitazone in experimental Wistar rats model of neurodegeneration: Effect of peroxisome proliferator-activated receptors-γ as advanced glycation endproducts receptor of advanced glycation endproducts axis inhibitor Open
Objectives: The interaction between advanced glycation end products (AGEs) and their receptor of AGE (RAGE) contributes to various disorders, which impact neurological conditions and cognitive function. This work aims to explore the potent…
View article: Unraveling the Mystery: A Case Report of Erythrodermic Psoriasis as an Adverse Reaction to Wellbutrin
Unraveling the Mystery: A Case Report of Erythrodermic Psoriasis as an Adverse Reaction to Wellbutrin Open
Understanding unintentional and adverse reactions to medications is key in pharmacologic therapy. These adverse effects can range from mild, well-tolerated symptoms to detrimental consequences for the patient. These symptoms can also range…
View article: Phytochemical Profiling and Anticancer Effect of Fagonia arabica on MCF-7 Breast Cancer Cells
Phytochemical Profiling and Anticancer Effect of Fagonia arabica on MCF-7 Breast Cancer Cells Open
This research analyzes the phytochemicals in Fagonia arabica leaves, revealing a strong presence of flavonoids, terpenoids, saponins, anthraquinones, cardiac glycosides, and tannins. The methanolic fraction, rich in gallic acid and rutin e…
View article: New Frontiers in Nutritional and Therapeutic Interventions for Obesity Phenotypes
New Frontiers in Nutritional and Therapeutic Interventions for Obesity Phenotypes Open
The heterogeneity among patients with obesity is particularly evident in the weight loss response to interventions such as diets, drugs, devices and surgery. Obesity can be “catalogued” into four phenotypes: hungry brain (abnormal satiety …
View article: Trends in Outpatient Opioid Prescriptions for Cancer Pain Between 2016 and 2021
Trends in Outpatient Opioid Prescriptions for Cancer Pain Between 2016 and 2021 Open
PURPOSE Increasing opioid regulations have resulted in reduced opioid prescriptions, including for cancer pain, despite guideline exemptions. Data after 2017 following the Centers for Disease Control's 2016 pain management guidelines are l…
View article: Age-Related Changes in Insulin Resistance and Muscle Mass: Clinical Implications in Obese Older Adults
Age-Related Changes in Insulin Resistance and Muscle Mass: Clinical Implications in Obese Older Adults Open
The older segment of the global population is increasing at a rapid pace. Advancements in public health and modern medicine lengthened life expectancy and reduced the burden of disease in communities worldwide. Concurrent with this demogra…
View article: 9182 Metastatic Extra-Gastrointestinal Stromal Tumor Presenting As Hypoglycemia
9182 Metastatic Extra-Gastrointestinal Stromal Tumor Presenting As Hypoglycemia Open
Disclosure: O. faour: None. D. John: None. S.K. Suryanarayanan: None. A.A. Rizvi: None. Introduction: Non islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome seen in association with solid abdominal tumors of mesenchyma…
View article: New Advances in Metabolic Syndrome
New Advances in Metabolic Syndrome Open
It is with great anticipation and pride that we present a Special Issue entitled “New Advances in Metabolic Syndrome”, which provides a compendium of high-quality original papers written on novel aspects of metabolic syndrome (MetS) [...]
View article: Development of a robotic cluster for automated and scalable cell therapy manufacturing
Development of a robotic cluster for automated and scalable cell therapy manufacturing Open
The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have contributed to high prices…
View article: Dietary Fructose and Serum Hyperfructosemia in Obese Non-Insulin Dependent Diabetic SHR/NTUL//-Cp Rats
Dietary Fructose and Serum Hyperfructosemia in Obese Non-Insulin Dependent Diabetic SHR/NTUL//-Cp Rats Open
To determine the effects of a high fructose diet on key glycemic parameters in non-insulin dependent rats, groups of lean and obese SHR/Ntul//-cp rats were fed nutritionally complete, isoenergetic diets containing 54% carbohydrate (CHO, w/…
View article: Heterozygous<i>Kmt2d</i>loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation
Heterozygous<i>Kmt2d</i>loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation Open
SUMMARY The histone H3 lysine 4 (H3K4) methyltransferase KMT2D (also called MLL4) is one of the most frequently mutated epigenetic modifiers in medulloblastoma (MB) and many other types of cancer. Notably, heterozygous loss of KMT2D is pre…
View article: Antidiabetic Molecule Efficacy in Patients with Type 2 Diabetes Mellitus—A Real-Life Clinical Practice Study
Antidiabetic Molecule Efficacy in Patients with Type 2 Diabetes Mellitus—A Real-Life Clinical Practice Study Open
In this paper, we aim to evaluate the efficacy of antidiabetic cardioprotective molecules such as Sodium-Glucose Cotransporter-2 Inhibitors (SGLT-2i) and Glucagon-like Peptide 1 Receptor Agonists (GLP-1 RAs) when used with other glucose-lo…
View article: The role of atherogenic lipoproteins in diabetes: Molecular aspects and clinical significance
The role of atherogenic lipoproteins in diabetes: Molecular aspects and clinical significance Open
Dyslipidaemia plays a prominent role in the genesis of atherosclerotic plaque and the increased cardiovascular risk in diabetes. Macrophages readily take up atherogenic lipoproteins, transforming into foam cells and amplifying vascular dam…
View article: A Critical View over the Newest Antidiabetic Molecules in Light of Efficacy—A Systematic Review and Meta-Analysis
A Critical View over the Newest Antidiabetic Molecules in Light of Efficacy—A Systematic Review and Meta-Analysis Open
The increase in life expectancy without a decrease in the years lived without disability leads to the rise of the population aged over 65 years prone to polypharmacy. The novel antidiabetic drugs can improve this global therapeutic and hea…
View article: Telemedicine for diabetes management during COVID-19: what we have learnt, what and how to implement
Telemedicine for diabetes management during COVID-19: what we have learnt, what and how to implement Open
The past two decades have witnessed telemedicine becoming a crucial part of health care as a method to facilitate doctor-patient interaction. Due to technological developments and the incremental acquisition of experience in its use, telem…
View article: Supplementary figures and legends from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer
Supplementary figures and legends from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer Open
Supplementary figures show the efficacy of TP-0903 and its effects on tumor infiltrating immune cells and EMT markers expression.
View article: Supplementary figures and legends from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer
Supplementary figures and legends from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer Open
Supplementary figures show the efficacy of TP-0903 and its effects on tumor infiltrating immune cells and EMT markers expression.
View article: Data from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer
Data from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer Open
Pancreatic cancer is the third leading cause of cancer-related deaths in the United States with a 5-year survival less than 5%. Resistance to standard therapy and limited response to immune checkpoint blockade due to the immunosuppressive …
View article: Data from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer
Data from AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer Open
Pancreatic cancer is the third leading cause of cancer-related deaths in the United States with a 5-year survival less than 5%. Resistance to standard therapy and limited response to immune checkpoint blockade due to the immunosuppressive …
View article: Advances in the Pharmacological Management of Diabetic Nephropathy: A 2022 International Update
Advances in the Pharmacological Management of Diabetic Nephropathy: A 2022 International Update Open
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. Its pathogenesis encompasses functional alterations involving elevated intraglomerular and systemic pressure, increased activity of the renin-angio…
View article: Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence
Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence Open
Periodontitis is a microbially driven, host-mediated disease that leads to loss of periodontal attachment and resorption of bone. It is associated with the elevation of systemic inflammatory markers and with the presence of systemic comorb…
View article: An Update on the Current and Emerging Use of Thiazolidinediones for Type 2 Diabetes
An Update on the Current and Emerging Use of Thiazolidinediones for Type 2 Diabetes Open
Guidelines have increasingly stressed the concept that adequate glycemic control is required to prevent or decrease the macro- and microvascular complications of type 2 diabetes mellitus (T2DM). PPAR-gamma agonists (“glitazones”) are no lo…