Arti Singh
YOU?
Author Swipe
View article: Reviving Lithium - A Sustainable Approach to Battery Recycling and Repurposing
Reviving Lithium - A Sustainable Approach to Battery Recycling and Repurposing Open
View article: Inhalable N-Acetylcysteine-loaded Lactose-coated PLGA Nanoparticles for Tuberculosis Treatment
Inhalable N-Acetylcysteine-loaded Lactose-coated PLGA Nanoparticles for Tuberculosis Treatment Open
Objective Glutathione (GSH), known for having mucolytic, anti-inflammatory, and antioxidant activities, is used in clinical practice in several pathologies, including tuberculosis (TB). N -acetylcysteine (NAC) has been primarily used to tr…
View article: Willingness To Pay (WTP) for Community-Based-Conservation Activities: A Comparative Study of Harike, Ropar and Nangal Wetlands in Punjab, India
Willingness To Pay (WTP) for Community-Based-Conservation Activities: A Comparative Study of Harike, Ropar and Nangal Wetlands in Punjab, India Open
Conservation of wetlands is essential because they provide numerous benefits to mankind in supporting human life, ecosystems and biodiversity, but predominant number of wetlands are at risk of degradation and loss due to both anthropogenic…
View article: Development of QCT loaded TPGS coated solid lipid nanoparticles for improved in vivo neuroprotective activity in LPS administered adult zebrafish model: A QbD-based approach
Development of QCT loaded TPGS coated solid lipid nanoparticles for improved in vivo neuroprotective activity in LPS administered adult zebrafish model: A QbD-based approach Open
This work contains the development of QCT-loaded TPGS-coated SLNs by QbD to enhance neuroinflammation potential. Developed SLNs were in the nanometer range (263±3.62 nm) with desired parameters i.e., PDI (0.244±0.003), zeta potential (28.2…
View article: Hydroalcoholic extract of Centella asiatica ameliorate on 3-nitropropionic acid induced Huntington's like symptoms in adult zebrafish
Hydroalcoholic extract of Centella asiatica ameliorate on 3-nitropropionic acid induced Huntington's like symptoms in adult zebrafish Open
Aim: Present study is design to investigate the effect of hydroalcoholic extract of Centella asiatica (HA-CA) in 3-nitro propionic acid induced Huntington’s disease in adult zebrafish. Material and method: In current study, adult zebrafish…
View article: Recent Advances in Delivery of Peptide and Protein Therapeutics to the Brain
Recent Advances in Delivery of Peptide and Protein Therapeutics to the Brain Open
The classes of neuropharmaceuticals known as proteins and peptides serve as diagnostic tools and are involved in specific communication in the peripheral and central nervous systems. However, due to tight junctions resembling epithelial ce…
View article: Piperine loaded drug delivery systems for improved biomedical applications: Current status and future directions
Piperine loaded drug delivery systems for improved biomedical applications: Current status and future directions Open
About 42 % of drugs with market acceptance and 92 % of drugs in the discovery pipeline are imperfectly aqueous soluble with insufficient intestinal absorption and will suffer from low oral bioavailability. Alkaloids are a group of phytonut…
View article: An update on breast cancer chemotherapy-associated toxicity and their management approaches
An update on breast cancer chemotherapy-associated toxicity and their management approaches Open
As the incidence rate of breast cancer is increasing at an alarming rate these days, this is leading to an increase in the use of chemotherapy drugs. Here we used a systematic review to identify studies that reported adverse events related…
View article: Drug delivery systems of gefitinib for improved cancer therapy: A review
Drug delivery systems of gefitinib for improved cancer therapy: A review Open
Lung cancer is an uncontrolled and abnormal mass of growing cells with the highest mortality rate in the world. Progressive lung cancer shows a robust resistance to cancer therapy; today no acceptable therapeutic results are achieved with …
View article: Inhalable N-Acetylcysteine loaded PLGA composites for Tuberculosis: In Vitro Aersolization and Efficacy Studies
Inhalable N-Acetylcysteine loaded PLGA composites for Tuberculosis: In Vitro Aersolization and Efficacy Studies Open
N-Acetylcysteine (NAC) is a precursor of Glutathione (GSH) which possess an immense potential of mucolytic, anti-inflammatory and antioxidant properties against several diseases including tuberculosis. Since last several decades, NAC is be…
View article: Modulating autophagy and mitophagy as a promising therapeutic approach in neurodegenerative disorders
Modulating autophagy and mitophagy as a promising therapeutic approach in neurodegenerative disorders Open
View article: The Role of Mitophagy in Various Neurological Diseases as a Therapeutic Approach
The Role of Mitophagy in Various Neurological Diseases as a Therapeutic Approach Open
View article: Emerging and advanced drug delivery systems for improved biopharmaceutical attributes of gallic acid: A review
Emerging and advanced drug delivery systems for improved biopharmaceutical attributes of gallic acid: A review Open
Background: Nearly 40–70% of the drug molecules in clinical drug development suffer from bioavailability issues attributed to poor solubility and absorption. Evidence reports the benefits of nano-technology-based strategies in enhancing ph…
View article: Ursolic acid along with Caprylic acid Ameliorates Pentylenetetrazole Induced Seizures Like Behavior in Adult Zebrafish
Ursolic acid along with Caprylic acid Ameliorates Pentylenetetrazole Induced Seizures Like Behavior in Adult Zebrafish Open
Background: Epilepsy is a neurological disorder characterized by recurrent unprovoked seizures. Despite the existence of more than 20 anti-epileptic drugs there is still a need for new treatments which could not only treat symptoms but als…
View article: Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction
Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction Open
Background Trametinib is an oral MEK 1/2 inhibitor, with a single agent recommended phase 2 dose (RP2D) of 2 mg daily (QD). This study was designed to evaluate RP2D, maximum tolerated dose (MTD), and pharmacokinetic (PK) profile of trameti…
View article: HDAC11: A novel inflammatory biomarker in Huntington’s disease
HDAC11: A novel inflammatory biomarker in Huntington’s disease Open
View article: Inhalation potential of N-Acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: In vitro lung deposition and efficacy studies
Inhalation potential of N-Acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: In vitro lung deposition and efficacy studies Open
Several studies have stated that mucus is a critical hurdle for drug delivery to the mucosal tissues. As a result, Polymeric nanoparticles that can overcome mucus barriers are gaining popularity for controlled drug delivery into intra-macr…
View article: Phase I Pharmacokinetic Study of Single Agent Trametinib in Patients With Advanced Cancer and Hepatic Dysfunction
Phase I Pharmacokinetic Study of Single Agent Trametinib in Patients With Advanced Cancer and Hepatic Dysfunction Open
BackgroundTrametinib is an oral MEK 1/2 inhibitor, with a single agent recommended phase 2 dose (RP2D) of 2 mg daily (QD). This study was designed to evaluate RP2D, maximum tolerated dose (MTD), and pharmacokinetic (PK) profile of trametin…
View article: Effect of hydro-alcoholic extract of centella asiatica on streptozotocin induced memory dysfunction in adult zebrafish
Effect of hydro-alcoholic extract of centella asiatica on streptozotocin induced memory dysfunction in adult zebrafish Open
View article: Pre-Treatment with Quercetin Prevents Dementia in Streptozotocin Treated Zebrafish via Modulation of Neuroinflammation and Oxidative Stress
Pre-Treatment with Quercetin Prevents Dementia in Streptozotocin Treated Zebrafish via Modulation of Neuroinflammation and Oxidative Stress Open
Aim: To examine the protective outcome of quercetin against streptozotocin induced dementia in adult zebrafish. Materials and method: In this study, adult zebrafish (weighing 470-530 mg) were subjected to the streptozotocin administration …
View article: Administration of Quercetin Ameliorates Lipopolysaccharide Induced Neuroinflammation and Oxidative Stress in Adult Zebrafish
Administration of Quercetin Ameliorates Lipopolysaccharide Induced Neuroinflammation and Oxidative Stress in Adult Zebrafish Open
Background: Quercetin is a natural flavonoid which is known to have numerous pharmacological activities such as antioxidative, anti-inflammatory and neuroprotective effects against various neurological disorders. Lipopolysaccharide (LPS) i…
View article: Understanding the Role of Histone Deacetylase and their Inhibitors inNeurodegenerative Disorders: Current Targets and Future Perspective
Understanding the Role of Histone Deacetylase and their Inhibitors inNeurodegenerative Disorders: Current Targets and Future Perspective Open
: Neurodegenerative diseases are the group of pathological conditions that cause motor inc-ordination (jerking movements), cognitive and memory impairments result due to degeneration of neurons in a specific area of the brain. Oxidative st…
View article: Antibacterial potential of selected phytomolecules: An experimental study
Antibacterial potential of selected phytomolecules: An experimental study Open
Antibiotic resistance is a snowballing international threat. Some of the antibiotics have lost their effectiveness due to overuse and underuse. Thus, there is an urgent need to tackle this global challenge, either by inhibiting the resista…
View article: Targeting N17 domain as a potential therapeutic target for the treatment of Huntington disease: An opinion
Targeting N17 domain as a potential therapeutic target for the treatment of Huntington disease: An opinion Open
View article: Crosstalk between anticancer drugs and mitochondrial functions
Crosstalk between anticancer drugs and mitochondrial functions Open
Chemotherapy is an important component of cancer treatment, which has side effects like vomiting, peripheral neuropathy, and numerous organ toxicity but the most significant outcomes of chemotherapy are cognitive impairment, which is mainl…
View article: Isolation and screening for novel bioactive molecules from endophytes associated with Arisaema erubescens (wall.) shott
Isolation and screening for novel bioactive molecules from endophytes associated with Arisaema erubescens (wall.) shott Open
View article: A Review on Placental Tuberculosis
A Review on Placental Tuberculosis Open
Tuberculosis has re-emerged as a serious health concern as a result of AIDS epidemic, immigration from areas where the disease is endemic and multi drug resistance, with 8.8 million patients affected worldwide in 2010. Infections with myco…
View article: Comparative Analysis of Intrahippocampal Amyloid Beta (1-42) and Intracerbroventricular Streptozotocin Models of Alzheimer's Disease: Possible Behavioral, Biochemical, Mitochondrial, Cellu lar and Histopathological Evidences
Comparative Analysis of Intrahippocampal Amyloid Beta (1-42) and Intracerbroventricular Streptozotocin Models of Alzheimer's Disease: Possible Behavioral, Biochemical, Mitochondrial, Cellu lar and Histopathological Evidences Open
Background: Alzheimer's disease (AD), one of the most common progressive neurodegenerative disorders that leads to dementia in aged humans. Amyloid beta [Aβ (1-42)] model has an ability to mimic many pathological aspects of human AD. Intra…
View article: Microglial Inhibitory Mechanism of Coenzyme Q10 Against Aβ (1-42) Induced Cognitive Dysfunctions: Possible Behavioral, Biochemical, Cellular, and Histopathological Alterations
Microglial Inhibitory Mechanism of Coenzyme Q10 Against Aβ (1-42) Induced Cognitive Dysfunctions: Possible Behavioral, Biochemical, Cellular, and Histopathological Alterations Open
The present study suggests that the neuroprotective effect of CoQ10 could be due to its microglia inhibitory mechanism along with its mitochondrial restoring and anti-oxidant properties.
View article: A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions
A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions Open
Neurodegenerative diseases are intricate in nature because of the involvement of the multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation and oxidative stress. Alzheimer's disease (AD) is a neurodegener…