Amanda M. Chipman
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View article: Early achievement of hemostasis defined by transfusion velocity: A possible mechanism for whole blood survival benefit
Early achievement of hemostasis defined by transfusion velocity: A possible mechanism for whole blood survival benefit Open
INTRODUCTION Whole blood resuscitation is associated with survival benefits in observational cohort studies. The mechanisms responsible for outcome benefits have not been adequately determined. We sought to characterize the achievement of …
View article: Biomarkers of endothelial cell dysfunction persist beyond resuscitation in patients with hemorrhagic shock
Biomarkers of endothelial cell dysfunction persist beyond resuscitation in patients with hemorrhagic shock Open
BACKGROUND It has been shown that microRNA-19b (miR-19b) binds to and degrades syndecan-1 after hemorrhagic shock (HS) and contributes to endothelial dysfunction in vitro and in vivo. The objective of the current study was to assess longit…
View article: Fibrinogen inhibits microRNA-19b, a novel mechanism for repair of haemorrhagic shock-induced endothelial cell dysfunction.
Fibrinogen inhibits microRNA-19b, a novel mechanism for repair of haemorrhagic shock-induced endothelial cell dysfunction. Open
We have demonstrated a novel mechanism by which fibrinogen, a key component of plasma and haemostatic agent, inhibits miR-19b, possibly by mitigating the endotheliopathy of trauma. Complete demonstration of the mechanism of fibrinogen inhi…
View article: Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study
Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study Open
BACKGROUND Despite the widespread institution of modern massive transfusion protocols with balanced blood product ratios, survival for patients with traumatic hemorrhage receiving ultramassive transfusion (UMT) (defined as ≥20 U of packed …
View article: Fibrinogen Activates PAK1/Cofilin Signaling Pathway to Protect Endothelial Barrier Integrity
Fibrinogen Activates PAK1/Cofilin Signaling Pathway to Protect Endothelial Barrier Integrity Open
Introduction: We recently demonstrated that fibrinogen stabilizes syndecan-1 on the endothelial cell (EC) surface and contributes to EC barrier protection, though the intracellular signaling pathway remains unclear. P21 (Rac1) activated ki…
View article: Fresh frozen plasma attenuates lung injury in a novel model of prolonged hypotensive resuscitation
Fresh frozen plasma attenuates lung injury in a novel model of prolonged hypotensive resuscitation Open
BACKGROUND Hemorrhagic shock remains a leading cause of early death among severely injured in both civilian and military settings. As future military operations will require strategies allowing prolonged field care of the injured, we sough…
View article: Is all plasma created equal? A pilot study of the effect of interdonor variability
Is all plasma created equal? A pilot study of the effect of interdonor variability Open
BACKGROUND Clinical benefits of plasma as an adjunct for treatment of hemorrhagic shock (HS) have been well established. However, its use is not without risk. Little is understood regarding the clinical implications of plasma variability. …
View article: Resuscitative Strategies to Modulate the Endotheliopathy of Trauma: From Cell to Patient
Resuscitative Strategies to Modulate the Endotheliopathy of Trauma: From Cell to Patient Open
Clinical data has supported the early use of plasma in high ratios of plasma to red cells to patients in hemorrhagic shock. The benefit from plasma seems to extend beyond its hemostatic effects to include protection to the post-shock dysfu…
View article: Patellofemoral pain syndrome in female athletes: A review of diagnoses, etiology and treatment options
Patellofemoral pain syndrome in female athletes: A review of diagnoses, etiology and treatment options Open
Patellofemoral pain syndrome (PFPS) is one of the most common causes of knee pain and is present in females disproportionately more relative to males. PFPS causes tend to be multifactorial in nature and are described in this review. From a…
View article: Pelvic organ prolapse: An industry-wide collaboration to identify putative contributing factors
Pelvic organ prolapse: An industry-wide collaboration to identify putative contributing factors Open
Amanda Chipman explains some of the data collected in the Pelvic Organ Prolapse project conducted by the Iowa Pork Industry Center. This is video #1 in a series of short videos about the project.\nFor more information: visit https://pigliv…