Agnete Larsen
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View article: Effects of Maternal Vitamin D Supplementation on Childhood Health
Effects of Maternal Vitamin D Supplementation on Childhood Health Open
Vitamin D deficiency during pregnancy is associated with an increased risk of health issues in the offspring. Accordingly, recent Endocrine Society guidelines strongly support supplementation in pregnancy, also underlining that without con…
View article: The Nationwide Impact of Guidelines for Prophylactic Aspirin Treatment for Preeclampsia
The Nationwide Impact of Guidelines for Prophylactic Aspirin Treatment for Preeclampsia Open
Background Preeclampsia is a common pregnancy complication associated with maternal and neonatal mortality. Early aspirin treatment lowers the risk of preeclampsia in high‐risk pregnancies. However, knowledge of aspirin's effects and possi…
View article: High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP
High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP Open
Increased vitD supplementation during pregnancy may ameliorate some overweight/obesity-induced inflammatory activity. Further studies are needed to determine the vitD need in pregnancies complicated by obesity and overweight.
View article: Maternal Demographic Patterns in Medication use During Pregnancy: A Nationwide Register Study
Maternal Demographic Patterns in Medication use During Pregnancy: A Nationwide Register Study Open
In recent years, medication use during pregnancy has increased, yet its association with maternal characteristics remains unclear. To address this gap, we aimed to investigate how maternal age, pre‐gestational body mass index (BMI), smokin…
View article: RETRACTED AND REPLACED: Effects of Maternal Vitamin D Supplementation on Childhood Health
RETRACTED AND REPLACED: Effects of Maternal Vitamin D Supplementation on Childhood Health Open
This article has been retracted and replaced. Please see https://doi.org/10.1210/endrev/bnaf031 for details. The replacement article can be found at https://doi.org/10.1210/endrev/bnaf034.
View article: Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status
Effects of High-Dose Vitamin D Supplementation on Placental Vitamin D Metabolism and Neonatal Vitamin D Status Open
Vitamin D (vitD) deficiency (25-hydroxy-vitamin D < 50 nmol/L) is common in pregnancy and associated with an increased risk of adverse pregnancy outcomes. High-dose vitD supplementation is suggested to improve pregnancy health, but there i…
View article: Maternal demographic patterns in medication use in pregnancy: a Danish nationwide register study
Maternal demographic patterns in medication use in pregnancy: a Danish nationwide register study Open
Aim More women than ever before use medication during pregnancy. This use of medications is associated with maternal demographic characteristics, but the nature of the associations is not well documented, especially in relation to polyphar…
View article: Use of medication in pregnancy on the rise: Study on 1.4 million Danish pregnancies from 1998 to 2018
Use of medication in pregnancy on the rise: Study on 1.4 million Danish pregnancies from 1998 to 2018 Open
Introduction Maternal demographics have evolved, and more women than ever enter pregnancy with preexisting comorbidity and with potentially complex medication exposure, including polypharmacy (concomitant intake of multiple medications). T…
View article: Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment Open
The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we rep…
View article: High-Dose Vitamin D Supplementation Significantly Affects the Placental Transcriptome
High-Dose Vitamin D Supplementation Significantly Affects the Placental Transcriptome Open
Vitamin D deficiency is a highly prevalent obstetrical concern associated with an increased risk of complications like pre-eclampsia, gestational diabetes, and growth retardation. Vitamin D status in pregnancy is also linked to long-term o…
View article: Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy
Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy Open
Background Vitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk. However, pregnant wo…
View article: A systematic overview of the spermatotoxic and genotoxic effects of methotrexate, ganciclovir and mycophenolate mofetil
A systematic overview of the spermatotoxic and genotoxic effects of methotrexate, ganciclovir and mycophenolate mofetil Open
Introduction Immunosuppressant drugs are increasingly being used in the reproductive years. Theoretically, such medications could affect fetal health either through changes in the sperm DNA or through fetal exposure caused by a presence in…
View article: Vitamin D insufficiency among Danish pregnant women—Prevalence and association with adverse obstetric outcomes and placental vitamin D metabolism
Vitamin D insufficiency among Danish pregnant women—Prevalence and association with adverse obstetric outcomes and placental vitamin D metabolism Open
Introduction In pregnancy, vitamin D deficiency is associated with increased risk of fetal growth restriction and preeclampsia. The underlying mechanisms are not known, but placental dysfunction is believed to play a role. In a Danish popu…
View article: Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents
Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents Open
Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and inflammation. Dysregulated lipid metabolism and mitochondrial dysfunction are hypothesized to play a key role in MS. Carnitine Palmitoyl Transferase …
View article: Reduced hepatic metallothionein expression in first trimester fetuses in response to intrauterine smoking exposure: a consequence of low maternal zinc levels?
Reduced hepatic metallothionein expression in first trimester fetuses in response to intrauterine smoking exposure: a consequence of low maternal zinc levels? Open
STUDY QUESTION Does maternal smoking in early pregnancy affect metallothionein 1 and 2 (MT1 and MT2) mRNA and protein expression in first trimester placenta or embryonic/fetal liver? SUMMARY ANSWER In the first trimester, MT protein expres…
View article: Use of alternative medicine, ginger and licorice among Danish pregnant women – a prospective cohort study
Use of alternative medicine, ginger and licorice among Danish pregnant women – a prospective cohort study Open
The use of licorice and alternative medicines appears to be common in pregnant Danish women, supporting the need for further investigations into the safety of alternative medicine use during pregnancy and the importance of up-to-date perso…
View article: Detection of Glycan Shedding in the Blood: New Class of Multiple Sclerosis Biomarkers?
Detection of Glycan Shedding in the Blood: New Class of Multiple Sclerosis Biomarkers? Open
In this study, we present data supporting the shedding of the GLX as a new class of biomarker for MS. In particular, soluble, sugar-based GLX components are associated with disease severity in two models of MS, molecules that would not be …
View article: Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with etomoxir or interferon-β
Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with etomoxir or interferon-β Open
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease, where chronic inflammation plays an essential role in its pathology. A feature of MS is the production of autoantibodies stimulated by an altered-peptide-ligand response an…
View article: Prevalence of xenobiotic substances in first-trimester blood samples from Danish pregnant women: a cross-sectional study
Prevalence of xenobiotic substances in first-trimester blood samples from Danish pregnant women: a cross-sectional study Open
Objective The aim of this study was to investigate the prevalence of xenobiotic substances, such as caffeine, nicotine and illicit drugs (eg, cannabis and cocaine), in blood samples from first-trimester Danish pregnant women unaware of the…
View article: Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome
Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome Open
Polycystic ovary syndrome (PCOS) is associated with infertility, increased androgen levels, and insulin resistance. In adipose tissue, zinc facilitates insulin signaling. Circulating zinc levels are altered in obesity, diabetes, and PCOS; …