Amanda D. Due
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View article: Hierarchy in regulator interactions with distant transcriptional activation domains empowers rheostatic regulation
Hierarchy in regulator interactions with distant transcriptional activation domains empowers rheostatic regulation Open
Transcription factors carry long intrinsically disordered regions often containing multiple activation domains. Despite numerous recent high‐throughput identifications and characterizations of activation domains, the interplay between sequ…
View article: Allovalent scavenging of activation domains in the transcription factor ANAC013 gears transcriptional regulation
Allovalent scavenging of activation domains in the transcription factor ANAC013 gears transcriptional regulation Open
Transcriptional regulation involves interactions between transcription factors, coregulators, and DNA. Intrinsic disorder is a major player in this regulation, but mechanisms driven by disorder remain elusive. Here, we address molecular co…
View article: Stereochemistry in the disorder–order continuum of protein interactions
Stereochemistry in the disorder–order continuum of protein interactions Open
Intrinsically disordered proteins can bind via the formation of highly disordered protein complexes without the formation of three-dimensional structure1. Most naturally occurring proteins are levorotatory (L)-that is, made up only of L-am…
View article: The importance of stereochemistry in the disorder-order continuum of protein-protein interactions
The importance of stereochemistry in the disorder-order continuum of protein-protein interactions Open
Intrinsically disordered proteins can bind via the formation of highly disordered protein complexes without the formation of 3D-structure. Most naturally occurring proteins are “left-handed” or levorotatory (L), made up only of L-amino aci…
View article: Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime
Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime Open
Transcription depends on complex networks, where folded hub proteins interact with intrinsically disordered transcription factors undergoing coupled folding and binding. For this, local residual structure, a prototypical feature of intrins…