Amanda Fisher
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View article: Lupus susceptibility gene <i>Pbx1</i> controls the development, stability, and function of regulatory T cells via <i>Rtkn2</i> expression
Lupus susceptibility gene <i>Pbx1</i> controls the development, stability, and function of regulatory T cells via <i>Rtkn2</i> expression Open
The maintenance of regulatory T (T reg ) cells critically prevents autoimmunity. Pre–B cell leukemia transcription factor 1 ( Pbx1 ) variants are associated with lupus susceptibility, particularly through the expression of a dominant negat…
View article: Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells Open
Maturation of an antibody response entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation and generation of memory B cells, and is thought to be generally dependent on T cell help. We show he…
View article: Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells Open
Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is thought to require T cell help. We showed that B cell Toll…
View article: Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4
Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4 Open
IgA is the predominant antibody isotype at intestinal mucosae, where it plays a critical role in homeostasis and provides a first line of immune protection. Dysregulation of IgA production, however, can contribute to immunopathology, parti…
View article: Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection
Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection Open
Significance Human cytomegalovirus (HCMV) is a β-herpesvirus that establishes life-long infection, leaving the risk of persistent reactivation and disease. Inhibition of viral entry into susceptible cells is an attractive strategy to preve…
View article: ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1
ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1 Open
Receptor-interacting protein kinase 1 (RIPK1) regulates cell fate and proinflammatory signaling downstream of multiple innate immune pathways, including those initiated by TNF-α, TLR ligands, and IFNs. Genetic ablation of Ripk1 results in …
View article: TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation Open
NLRP3 inflammasome plays a critical spatiotemporal role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). This study reports a mechanistic insight into noncanonical NLRP3 inflammasome activation in microglia for the e…
View article: Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1
Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1 Open
Necroptosis complements apoptosis as a host defense pathway to stop virus infection. Herpes simplex virus shows a propensity to trigger necroptosis of mouse cells and mice even though cell death is blocked in human cells through UL39-encod…