Amanda E. Appel
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View article: In Silico Identification and Molecular Characterization of Lentilactobacillus hilgardii Antimicrobial Peptides with Activity Against Carbapenem-Resistant Acinetobacter baumannii
In Silico Identification and Molecular Characterization of Lentilactobacillus hilgardii Antimicrobial Peptides with Activity Against Carbapenem-Resistant Acinetobacter baumannii Open
Background/Objectives: Biofilm formation by Acinetobacter baumannii contributes to its persistence in clinical settings and resistance to antibiotic treatment. This study aims to identify and characterize antimicrobials from lactic acid ba…
View article: <em>In Silico</em> Identification and Molecular Characterization of <em>Lentilactobacillus hilgardii </em>Antimicrobial Peptides with Activity Against Carbapenem-Resistant <em>Acinetobacter baumannii</em>
<em>In Silico</em> Identification and Molecular Characterization of <em>Lentilactobacillus hilgardii </em>Antimicrobial Peptides with Activity Against Carbapenem-Resistant <em>Acinetobacter baumannii</em> Open
This study investigates the efficacy of conditioned media derived from lactic acid bacteria (LAB) in preventing and disrupting Acinetobacter baumannii biofilms. Of the 13 LAB isolates from the Human Microbiome Project tested, five distinct…
View article: Sampling techniques and genomic analysis of biological material from artworks
Sampling techniques and genomic analysis of biological material from artworks Open
The genomic analysis of biological material from artworks can be used to guide curation, preservation, and restoration. Additionally, human DNA recovered from artworks may provide other insights. However, the recovery of biological samples…
View article: Secondary Transcriptomic Analysis of Triple-Negative Breast Cancer Reveals Reliable Universal and Subtype-Specific Mechanistic Markers
Secondary Transcriptomic Analysis of Triple-Negative Breast Cancer Reveals Reliable Universal and Subtype-Specific Mechanistic Markers Open
Background/Objectives: Breast cancer is diagnosed in 2.3 million women each year and kills 685,000 (~30% of patients) worldwide. The prognosis for many breast cancer subtypes has improved due to treatments targeting the estrogen receptor (…
View article: Multiomic Insights into Human Health: Gut Microbiomes of Hunter-Gatherer, Agropastoral, and Western Urban Populations
Multiomic Insights into Human Health: Gut Microbiomes of Hunter-Gatherer, Agropastoral, and Western Urban Populations Open
Societies with exposure to preindustrial diets exhibit improved markers of health. Our study used a comprehensive multi-omic approach to reveal that the gut microbiome of the Ju/’hoansi hunter-gatherers, one of the most remote KhoeSan grou…
View article: Secondary Transcriptomic Analysis of Triple Negative Breast Cancer Reveals Reliable Universal and Subtype-Specific Biomarkers
Secondary Transcriptomic Analysis of Triple Negative Breast Cancer Reveals Reliable Universal and Subtype-Specific Biomarkers Open
Breast cancer is diagnosed in 2.3 million women each year, and kills 685,000 (~30% of patients) worldwide. Breast cancer prognosis for many subtypes has improved due to treatments targeting Estrogen Receptor (ER), Progesterone Receptor (PR…
View article: Sampling Techniques and Genomic Analysis of Biological Material from Artworks
Sampling Techniques and Genomic Analysis of Biological Material from Artworks Open
The genomic analysis of biological material obtained from artwork or cultural heritage artifacts can be used to guide curation, preservation and restoration. However, the recovery of biological samples from artworks is dependent on the sam…
View article: SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization
SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization Open
Streptococcus pneumoniae ( Spn ), a Gram-positive bacterium, is responsible for causing a wide variety of invasive infections. The emergence of multi-drug antibiotic resistance has prompted the search for antimicrobial alternatives. Phage-…
View article: Physiological and interspecific factors determine diel changes in phytoplankton bio‐optical properties
Physiological and interspecific factors determine diel changes in phytoplankton bio‐optical properties Open
Bio‐optical properties of marine phytoplankton retrieved through satellite remote sensing are used to estimate ocean productivity and carbon cycling. Daily activity of phytoplankton is attuned to the predictable light fluctuations of the d…