Amanda E. Balaban
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View article: The Plasmodium CSP repeats have elastic properties with a critical role in sporozoite motility
The Plasmodium CSP repeats have elastic properties with a critical role in sporozoite motility Open
The Plasmodium circumsporozoite protein (CSP) is the major surface protein of the sporozoite, the infective stage of the malaria parasite. The central repeat region of CSP is the primary immunological target of the sporozoite stage, yet li…
View article: Nonmuscle myosin IIB is a driver of cellular reprogramming
Nonmuscle myosin IIB is a driver of cellular reprogramming Open
To test the impact of engineering cells with altered contractile properties, NMIIB and mutants that have different assembly and force-generating properties were introduced. Adding NMIIB into pancreatic ductal epithelia–derived cancer cells…
View article: The repeat region of the circumsporozoite protein is an elastic linear spring with a functional role in <i>Plasmodium</i> sporozoite motility
The repeat region of the circumsporozoite protein is an elastic linear spring with a functional role in <i>Plasmodium</i> sporozoite motility Open
The circumsporozoite protein (CSP) forms a dense coat on the surface of the sporozoite, the infective stage of the malaria parasite. The central repeat region of CSP is a critical component of the only licensed malaria vaccine yet little i…
View article: The fibrinolytic system enables the onset of <i>Plasmodium</i> infection in the mosquito vector and the mammalian host
The fibrinolytic system enables the onset of <i>Plasmodium</i> infection in the mosquito vector and the mammalian host Open
Plasmodium uses the fibrinolytic system to overcome physical barriers in the mosquito and vertebrate host.
View article: Antibody-Mediated Protection against <i>Plasmodium</i> Sporozoites Begins at the Dermal Inoculation Site
Antibody-Mediated Protection against <i>Plasmodium</i> Sporozoites Begins at the Dermal Inoculation Site Open
Studies in experimental animal models and humans have shown that antibodies against Plasmodium sporozoites abolish parasite infectivity and provide sterile immunity. While it is well documented that these antibodies can be induced after im…
View article: Robust fluorescent labelling of micropipettes for use in fluorescence microscopy: application to the observation of a mosquito borne parasite infection
Robust fluorescent labelling of micropipettes for use in fluorescence microscopy: application to the observation of a mosquito borne parasite infection Open
Summary The ability to monitor micropipette injections with a high‐resolution fluorescent microscope has utility for a variety of applications. Herein, different approaches were tested for creating broad‐band fluorescently labelled glass m…
View article: Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice
Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice Open
A devastating complication of Plasmodium falciparum infection is cerebral malaria, in which vascular leakage and cerebral swelling lead to coma and often death. P. falciparum produces a protein called histidine-rich protein II (HRPII) that…