Amanda E. Brinker
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View article: Supplemental Figure 3 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 3 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 3. Integrative analysis of methylation and gene expression. The methylation level for the five most differentially expressed genes (listed at the top of each page), for which also methylation data was available, is show…
View article: SF1 from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
SF1 from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner Open
Supplementary Figure S1: Genotyping of MNX strains. Representative gels showing genotyping of MNX and matching wild-type strains. Total DNA was isolated from tail clips of weanling mice. DNA was amplified using primers that span A: 9461 Câ…
View article: SF1 from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
SF1 from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner Open
Supplementary Figure S1: Genotyping of MNX strains. Representative gels showing genotyping of MNX and matching wild-type strains. Total DNA was isolated from tail clips of weanling mice. DNA was amplified using primers that span A: 9461 Câ…
View article: Supplementary Table S1: Primer sequences for RFLP sites and Her2 transgene from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
Supplementary Table S1: Primer sequences for RFLP sites and Her2 transgene from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner Open
Supplementary Table S1: Primer sequences for RFLP sites and Her2 transgene
View article: Supplemental Figure 2 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 2 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 2. Deduplication and alignment statistics. a. Bismark v0.10.1 was used for alignment and deduplication. Duplicates were discarded using deduplicate_bismark perl script. With total number of alignments analyzed (red), to…
View article: Supplemental Figure 2 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 2 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 2. Deduplication and alignment statistics. a. Bismark v0.10.1 was used for alignment and deduplication. Duplicates were discarded using deduplicate_bismark perl script. With total number of alignments analyzed (red), to…
View article: Data from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
Data from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner Open
Using a novel mouse model, a mitochondrial-nuclear exchange model termed MNX, we tested the hypothesis that inherited mitochondrial haplotypes alter primary tumor latency and metastatic efficiency. Male FVB/N-Tg(MMTVneu)202Mul/J (Her2) tra…
View article: Supplementary Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner
Supplementary Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner Open
S1: Neither mitochondrial load nor membrane potential differ between MNX and wild-type strains. Mouse embryonic fibroblasts were isolated from each MNX and wild-type strain and stained with MitoTracker Green FM to identify overall mitochon…
View article: Supplemental Figure 7 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 7 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 7. Apoptosis Analysis. Annexin V-FITC/propidium iodide (PI) staining assay were used to measure apoptosis in MEFs harvested from the following strains: FF, FC, BB, FB, CC, CH, HH, HC (as described in Table 1). Apoptotic…
View article: Supplemental Figure 5 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 5 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 5. Litter sizes and gender distribution. Female to male ratios with the average litter size and total number of mice used for each strain. For the female to male ratio the average litter size was calculated from over 20…
View article: Supplemental Figure 1 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 1 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 1. Validation of Methyl-Seq and RNA-Seq. Several hypo-/hyper-methylated and down-/up-regulated genes were selected for validation using methylation specific primers (64) or quantitative PCR, respectively. Graphs depict …
View article: Supplemental Figure 4 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 4 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 4. Life Span. Life span of the MNX strains was measured in days and compared to the vendor information (Jackson Laboratories for C57Bl/6 and FVB/NJ mice and Envigo Laboratories for C3H/HeN mice). N= 15 for the females. …
View article: Supplemental Figure 1 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 1 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 1. Validation of Methyl-Seq and RNA-Seq. Several hypo-/hyper-methylated and down-/up-regulated genes were selected for validation using methylation specific primers (64) or quantitative PCR, respectively. Graphs depict …
View article: Supplementary Table S1: Primer sequences for RFLP sites and Her2 transgene from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
Supplementary Table S1: Primer sequences for RFLP sites and Her2 transgene from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner Open
Supplementary Table S1: Primer sequences for RFLP sites and Her2 transgene
View article: Data from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Data from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse …
View article: Supplemental Figure 6 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 6 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 6. Cell Cycle Analysis. Cell cycle analysis using propidium iodide (PI) staining was performed on mouse embryo fibroblasts (MEFs) harvested from the following strains: FF, FC, BB, FB, CC, CH, HH, HC (as described in Tab…
View article: Data from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner
Data from Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver–Dependent Manner Open
Using a novel mouse model, a mitochondrial-nuclear exchange model termed MNX, we tested the hypothesis that inherited mitochondrial haplotypes alter primary tumor latency and metastatic efficiency. Male FVB/N-Tg(MMTVneu)202Mul/J (Her2) tra…
View article: Data from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Data from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse strain and homoplasmic mitochondrial haplotypes from different mouse …
View article: Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner
Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner Open
Mitochondria contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calcium signaling, and apoptosis. Using the Mitochondrial Nuclear Exchange (MNX) mouse models, which pair nuclear genomes with dif…
View article: Supplemental Figure 6 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 6 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 6. Cell Cycle Analysis. Cell cycle analysis using propidium iodide (PI) staining was performed on mouse embryo fibroblasts (MEFs) harvested from the following strains: FF, FC, BB, FB, CC, CH, HH, HC (as described in Tab…
View article: Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner
Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner Open
Mitochondria contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calcium signaling, and apoptosis. Using the Mitochondrial Nuclear Exchange (MNX) mouse models, which pair nuclear genomes with dif…
View article: Supplemental Figure 4 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 4 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 4. Life Span. Life span of the MNX strains was measured in days and compared to the vendor information (Jackson Laboratories for C57Bl/6 and FVB/NJ mice and Envigo Laboratories for C3H/HeN mice). N= 15 for the females. …
View article: Supplemental Figure 5 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 5 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 5. Litter sizes and gender distribution. Female to male ratios with the average litter size and total number of mice used for each strain. For the female to male ratio the average litter size was calculated from over 20…
View article: Supplemental Figure 3 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 3 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 3. Integrative analysis of methylation and gene expression. The methylation level for the five most differentially expressed genes (listed at the top of each page), for which also methylation data was available, is show…
View article: Supplementary Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner
Supplementary Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner Open
S1: Neither mitochondrial load nor membrane potential differ between MNX and wild-type strains. Mouse embryonic fibroblasts were isolated from each MNX and wild-type strain and stained with MitoTracker Green FM to identify overall mitochon…
View article: Supplemental Figure 7 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression
Supplemental Figure 7 from Mitochondrial Genomic Backgrounds Affect Nuclear DNA Methylation and Gene Expression Open
Supplemental Figure 7. Apoptosis Analysis. Annexin V-FITC/propidium iodide (PI) staining assay were used to measure apoptosis in MEFs harvested from the following strains: FF, FC, BB, FB, CC, CH, HH, HC (as described in Table 1). Apoptotic…
View article: The Impact of Nanoparticles on the Immune System: A Gray Zone of Nanomedicine
The Impact of Nanoparticles on the Immune System: A Gray Zone of Nanomedicine Open
Since the early days marking the first use of nanomedicine in the early 80s, there has been a meaningful change in the scientific field involving the Fabrication, characterization, and application of nanomaterials to treat many diseases, i…
View article: Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner
Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner Open
Mitochondria contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calcium signaling, and apoptosis. Using the Mitochondrial Nuclear Exchange (MNX) mouse models, which pair nuclear genomes with dif…