Amanda Feilding
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View article: A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers
A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers Open
Background Preliminary research indicates that psychedelics may hold promise as analgesic agents. This study investigated the potential analgesic effects of lysergic acid diethylamide (LSD) microdosing on pain tolerance and subjective pain…
View article: Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being
Autonomic nervous system activity correlates with peak experiences induced by DMT and predicts increases in well-being Open
Background: Non-ordinary states of consciousness induced by psychedelics can be accompanied by so-called “peak experiences,” characterized at the emotional level by their intensity and positive valence. These experiences are strong predict…
View article: LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids
LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids Open
Proteomic analysis of human cerebral organoids may reveal how psychedelics regulate biological processes, shedding light on drug-induced changes in the brain. This study elucidates the proteomic alterations induced by lysergic acid diethyl…
View article: Inter-individual variability in neural response to low doses of LSD
Inter-individual variability in neural response to low doses of LSD Open
The repeated use of small doses of psychedelics (also referred to as “microdosing”) to facilitate benefits in mental health, cognition, and mood is a trending practice. Placebo-controlled studies however have largely failed to demonstrate …
View article: Autonomic Nervous System activity correlates with peak experiences induced by DMT and predicts increases in wellbeing
Autonomic Nervous System activity correlates with peak experiences induced by DMT and predicts increases in wellbeing Open
Non-ordinary states of consciousness induced by psychedelics can be accompanied by so-called ‘peak experiences’, characterized at the emotional level by their intensity and positive valence. These experiences are strong predictors of posit…
View article: LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids
LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids Open
Proteomic analysis of human cerebral organoids may reveal how psychedelics regulate biological processes, shedding light on drug-induced changes in the brain. This study elucidates the proteomic alterations induced by lysergic acid diethyl…
View article: Effects of External Stimulation on Psychedelic State Neurodynamics
Effects of External Stimulation on Psychedelic State Neurodynamics Open
Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes, such as personality changes. The…
View article: Potential analgesic effects of psychedelics on select chronic pain conditions: A survey study
Potential analgesic effects of psychedelics on select chronic pain conditions: A survey study Open
Background Chronic pain is a major cause of suffering and disability and is often associated with psychiatric complications. Current treatments carry the risk of severe side effects and may lead to limited or no relief at all in a relevant…
View article: Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging
Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging Open
(1) From mouse to man, shaking behavior (head twitches and/or wet dog shakes) is a reliable readout of psychedelic drug action. Shaking behavior like psychedelia is thought to be mediated by serotonin 2A receptors on cortical pyramidal cel…
View article: Psilocybin induces acute and persisting alterations in immune status and the stress response in healthy volunteers
Psilocybin induces acute and persisting alterations in immune status and the stress response in healthy volunteers Open
Patients characterized by stress-related disorders such as depression display elevated circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis. Psychedelics are demonstrating promising results in treatment of su…
View article: LSD, Madness and Healing: Mystical Experiences as Possible Link Between Psychosis Model and Therapy Model
LSD, Madness and Healing: Mystical Experiences as Possible Link Between Psychosis Model and Therapy Model Open
For a century, two paradoxical models have dominated the research with classic psychedelics [1] :This study sought to elucidate this paradoxical relationship by exploring the LSD psychosis model and therapy model, as measured by aberrant s…
View article: Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers: a population survey
Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers: a population survey Open
Although several studies and reports have shown the potential analgesic use of serotonergic psychedelics in cancer pain, phantom limb pain and cluster headache, evidence supporting their use for chronic pain is still limited. The past year…
View article: The Shipibo Ceremonial Use of Ayahuasca to Promote Well-Being: An Observational Study
The Shipibo Ceremonial Use of Ayahuasca to Promote Well-Being: An Observational Study Open
Promoting well-being is one of the main goals to improve health in the world. We examined the well-being and quality of life over the course of one year in a sample that participated in an Indigenous Shipibo healing program where tradition…
View article: Self-blinding citizen science to explore psychedelic microdosing
Self-blinding citizen science to explore psychedelic microdosing Open
Microdosing is the practice of regularly using low doses of psychedelic drugs. Anecdotal reports suggest that microdosing enhances well-being and cognition; however, such accounts are potentially biased by the placebo effect. This study us…
View article: Corrigendum: Four Weekly Ayahuasca Sessions Lead to Increases in “Acceptance” Capacities: A Comparison Study with a Standard 8-Week Mindfulness Training Program
Corrigendum: Four Weekly Ayahuasca Sessions Lead to Increases in “Acceptance” Capacities: A Comparison Study with a Standard 8-Week Mindfulness Training Program Open
In the published article, there was an error in affiliation 3. Instead of “Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain”, it should be “Department of Pharmacology, Therapeutics and Toxico…
View article: Author response: Self-blinding citizen science to explore psychedelic microdosing
Author response: Self-blinding citizen science to explore psychedelic microdosing Open
Article Figures and data Abstract eLife digest Introduction Materials and methods Results Discussion Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Microdosing is the…
View article: Effects of external stimulation on psychedelic state neurodynamics
Effects of external stimulation on psychedelic state neurodynamics Open
Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes such as personality changes. Thes…
View article: Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study
Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study Open
There is a popular interest in microdosing with psychedelics such as LSD. This practice of using one-tenth of a full psychedelic dose according to a specific dosing schedule, anecdotally enhances mood and performance. Nonetheless, controll…
View article: Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants
Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants Open
“Microdoses” of lysergic acid diethylamide (LSD) are used recreationally to enhance mood and cognition. Increasing interest has also been seen in developing LSD into a medication. Therefore, we performed a pharmacokinetic‐pharmacodynamic s…
View article: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers
Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers Open
Despite preclinical evidence for psychedelic-induced neuroplasticity, confirmation in humans is grossly lacking. Given the increased interest in using low doses of psychedelics for psychiatric indications and the importance of neuroplastic…
View article: A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers
A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers Open
Background: Lysergic acid diethylamide (LSD) is an ergot alkaloid derivative with psychedelic properties that has been implicated in the management of persistent pain. Clinical studies in the 1960s and 1970s have demonstrated profound anal…
View article: Acute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment
Acute effects of MDMA on trust, cooperative behaviour and empathy: A double-blind, placebo-controlled experiment Open
Background: 3,4-Methylenedioxymethamphetamine (MDMA) is being actively researched as an adjunct to psychotherapy. It may be beneficial to trust, empathy and cooperative behaviour due to its acute prosocial effects. Aim: To test (a) the acu…
View article: Neural correlates of the LSD experience revealed by multimodal neuroimaging
Neural correlates of the LSD experience revealed by multimodal neuroimaging Open
Lysergic acid diethylamide (LSD), the prototypical “psychedelic,” may be unique among psychoactive substances. In the decades that followed its discovery, the magnitude of its effect on science, the arts, and society was unprecedented. LSD…