Explanipedia

Prenatal fluoride exposure and autistic behaviors in preschool-aged children: the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort study Open

Adele Carty, John McLaughlin, Howard Hu, Bruce P. Lanphear, E. Angeles Martínez‐Mier , et al. · 2025

There was no evidence of an association between prenatal fluoride exposure and autistic behaviors in preschool-aged children, in contrast to previous MIREC research findings on lead and phthalates. Given that this cohort has relatively few…

Arsenic, Cadmium, Lead, Mercury, and PFAS Exposure During Pregnancy or Lactation and Respective Concentrations in Human Milk: Systematic Review Open

Trish Bosse, Mandy Fisher, Aubrey L. Galusha, Carin Huset, Maureen K Spill , et al. · 2025

Contaminant exposure during pregnancy or lactation may result in contaminant transfer into human milk (HM). This systematic review (PROSPERO# CRD42024530326) assessed relationships between arsenic, cadmium, lead, mercury, and per- and poly…

Identifying the Safe and Adequate Folic Acid Intake Range Using Biomarkers in 2 Mouse Models Open

Esther Munezero, Kathryn E. Hopperton, Nathalie A. Behan, Fernando Matias, Jeremiah Gaudet , et al. · 2025

The AIN-93 diet, the most commonly used control diet, contains 2 mg FA/kg diet, which is higher than adequate. On the basis of increased UMFA, commonly used supplemental FA doses associated with adverse effects in mice are supraphysiologic…

Assessment of arsenic, cadmium, lead, mercury, and per- and polyfluoroalkyl substances concentrations in human milk and infant formula in the United States: a systematic review Open

Rachel C Thoerig, Lauren E O’Connor, Maureen K Spill, Arin A. Balalian, Rupal Trivedi , et al. · 2025

In published, peer-reviewed United States studies, PFOA and PFOS were detected in HM; PFAS were largely undetected in IF. There was a paucity of contemporary evidence for arsenic, cadmium, lead, and mercury in HM or IF in the United States…

Altered sperm DNA methylation in overweight men associates transposable element regulation to paternal origins of disease risk in children Open

Sarah Kimmins, Mathieu Schulz, Xiaojian Shao, Romain Lambrot, Christine Lafleur , et al. · 2025

The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association betw…

Association between gestational environmental chemical mixtures and folate exposures with autistic behaviors in a Canadian birth cohort Open

Joshua D. Alampi, Bruce P. Lanphear, Amanda J MacFarlane, Joseph M. Braun, Youssef Oulhote , et al. · 2025

Background: Prenatal exposure to environmental chemicals may be associated with autism or autistic-like behaviors. Previous studies suggest that these associations are stronger when folic acid (FA) supplementation is lower. Methods: We use…

Report of a Meeting: An Expert Consultation on Body Composition and Adiposity for Children and Adolescents in All Their Diversity Open

Lauren E O’Connor, Lucero Lopez-Perez, Ricardo X Martinez, Arin A. Balalian, Juan Pablo Peña-Rosas , et al. · 2025

Systematic review of the impact of ginger extract and alpinetin on pregnancy outcomes in animal models Open

Jessica O. Williams, Kendra A. Tiani, Margaret Foster, Amanda J MacFarlane, Regan L Bailey , et al. · 2025

Background The objective of this systematic review was to evaluate existing scientific evidence regarding the effectiveness and safety of preparations of bioactive compounds of the Zingiberaceae family in animal models during gestation and…

Contaminant Composition of Human Milk in the US: A Systematic Review Open

Arin A. Balalian, Rachel C Thoerig, Lauren E O’Connor, Arin A. Balalian, Rupal Trivedi , et al. · 2025

Examination of the Current Evidence on Suboptimal Vitamin B12 Status and Neuropsychiatric Outcomes Open

Samantha Yoo, Azita Montazeri, Derrick Bennett, Peizhan Chen, Susan J. Duthie , et al. · 2025

Infant Exposure to Heavy Metals and PFAS in the United States: A Systematic Review Open

Cassi N Uffelman, Lauren E O’Connor, Rachel C Thoerig, Arin A. Balalian, Shailesh Advani , et al. · 2025

Contaminant Composition of Infant Formulas in the US: A Systematic Review Open

Rachel C Thoerig, Lauren E O’Connor, Arin A. Balalian, Arin A. Balalian, Shailesh M Advani , et al. · 2025

Effect of Endocrine-Disrupting Chemicals on Obesity in Children and Adolescents: A Systematic Review Protocol Open

Arin A. Balalian, Arin A. Balalian, Lauren E O’Connor, Margaret Foster, Katherine Holland , et al. · 2025

Assessing the Supplemental Nutrition Assistance Program (SNAP): A Systematic Review Protocol Open

Trish Bosse, Arin A. Balalian, Shailesh Advani, Rachel C Thoerig, Cassi N Uffelman , et al. · 2025

Bioavailability of Contaminants in Human Milk and Infant Formula When Consumed by the Infant: A Systematic Review Open

Shailesh Advani, Lauren E O’Connor, Rachel C Thoerig, Cassi N Uffelman, Maureen K Spill , et al. · 2025

Contaminant Exposure During Pregnancy and Lactation and Contaminant Concentrations in Human Milk: A Systematic Review Open

Lauren E O’Connor, Rachel C Thoerig, Cassi N Uffelman, Arin A. Balalian, Shailesh M Advani , et al. · 2025

Agricultural Production Processes and Heavy Metal Contaminants in Foods for Human Consumption: A Scoping Review and Research Gap Map Open

Rupal Trivedi, Arin A. Balalian, Cassi N Uffelman, Tibor Bosse, Arin A. Balalian , et al. · 2025

Seafood During Pregnancy and Lactation and Child Neurocognitive Development: A Systematic Review Open

Lauren E O’Connor, Arin A. Balalian, Sanjoy Saha, Arin A. Balalian, Julie S Davis , et al. · 2025

Seafood consumption within currently recommended amounts during pregnancy may be associated with better social-emotional, behavioral, and aggregate scores of development in the child, as well as potentially some aspects of cognitive develo…

Associations of prenatal glyphosate exposure with child neurodevelopment in a Canadian pregnancy cohort study Open

Meaghan Hall, Jillian Ashley‐Martin, Christine Till, Janice M. Y. Hu, Bruce P. Lanphear , et al. · 2025

In this primarily urban cohort of Canadian mother-child pairs, prenatal glyphosate and AMPA exposure were not significantly associated with child neurodevelopment. Further evaluation of glyphosate as a potential developmental neurotoxicant…

Folic Acid-Containing Supplement Use among Females Aged 15–55 in the Canadian Community Health Survey 2015–2018 Open

Kathryn E. Hopperton, Lidia Loukine, The Minh Luong, Loan Nguyen, Jesse Bertinato , et al. · 2025

Although most females living in Canada reported using folic acid-containing supplements prior to and during pregnancy, use of these supplements among nonpregnant females of childbearing age is low, and sociodemographic inequalities exist.

Mercury exposure and childhood outcomes: An overview of systematic reviews Open

Lauren E O’Connor, Maureen K Spill, Rupal Trivedi, Sanjoy Saha, Rachel Thoerig , et al. · 2025

Mercury exposure during pregnancy and childhood is recognized as a major public health concern. However, more research is needed that specifically examines methylmercury from seafood to better inform future dietary recommendations.

Seafood and Neurocognitive Development in Children: A Systematic Review Open

Lauren E O’Connor, Arin A. Balalian, Sanjoy Saha, Arin A. Balalian, Julie S Davis , et al. · 2025

Association between Maternal Lead Exposure from Seafood Consumption and Neurodevelopment: A Systematic Review Open

Arin A. Balalian, Arin A. Balalian, Rachel C Thoerig, Rupal Trivedi, Sanjoy Saha , et al. · 2025

Profiles and predictors of child neurodevelopment and anthropometry: The maternal-infant research on environmental chemicals study Open

Marisa A. Patti, Karl T. Kelsey, Amanda J MacFarlane, George D. Papandonatos, Bruce P. Lanphear , et al. · 2025

Background Evaluating individual health outcomes does not capture co-morbidities children experience. Purpose We aimed to describe profiles of child neurodevelopment and anthropometry and identify their predictors. Methods Using data from …

Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile Open

Megan M. Knuth, Carolina Vieira Campos, Kirsten Smith, Elizabeth K Hutchins, Shantae Lewis , et al. · 2024

Seafood Toxicant Exposure During Pregnancy, Lactation, and Childhood and Child Outcomes: A Scoping Review Open

Rupal Trivedi, Arin A. Balalian, Sanjoy Saha, Rachel C Thoerig, Julie S Davis , et al. · 2024

Determining dietary recommendations for seafood consumed during pregnancy, lactation, and childhood requires consideration of the known nutritional benefits and potential harm due to toxicant exposure as they relate to child outcomes. This…

Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile Open

Megan M. Knuth, Carolina Vieira Campos, Kirsten Smith, Elizabeth K Hutchins, Shantae Lewis , et al. · 2024

Associations Between Maternal Polychlorinated Biphenyls (PCBs) Exposure from Seafood Consumption during Pregnancy and Lactation and Child Growth: A Systematic Review and Meta-Analysis Open

Arin A. Balalian, Arin A. Balalian, Rachel C Thoerig, Rupal Trivedi, Sanjoy Saha , et al. · 2024

Artificial intelligence in food and nutrition evidence: The challenges and opportunities Open

Regan L Bailey, Amanda J MacFarlane, Martha S. Field, Ilias Tagkopoulos, Sergio E. Baranzini , et al. · 2024

Science-informed decisions are best guided by the objective synthesis of the totality of evidence around a particular question and assessing its trustworthiness through systematic processes. However, there are major barriers and challenges…

Concentrations and predictors of select nutrients in Canadian human milk samples from the Maternal-Infant Research on Environmental Chemicals pregnancy cohort Open

Kathryn E. Hopperton, Erica O’Neill, Subhadeep Chakrabarti, Melanie Stanton, Sophie Parnel , et al. · 2024

HM mineral concentrations from this study meet the methodological inclusion criteria for updating nutrient databank values and dietary reference intakes. Consideration of factors such as diet, skin color, and BMI will be important for sele…

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