Amanda J. Wright
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View article: Triacylglycerol Crystallinity and Emulsion Colloidal Acid Stability Influence In Vitro Digestion Lipolysis and Bioaccessibility of Long-Chain Omega-3 Fatty Acid-Rich Nanoemulsions
Triacylglycerol Crystallinity and Emulsion Colloidal Acid Stability Influence In Vitro Digestion Lipolysis and Bioaccessibility of Long-Chain Omega-3 Fatty Acid-Rich Nanoemulsions Open
This study investigated the relationships between emulsion droplet triacylglycerol (TAG) crystallinity and colloidal acid stability on in vitro digestion microstructure, lipolysis, and docosahexaenoic acid (DHA) bioaccessibility. Oil-in-wa…
View article: Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium
Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium Open
Stiffening of tissue is a hallmark of cancer progression, promoting invasive phenotypes through altered cell‐extracellular matrix (ECM) interactions. However, how fully formed epithelial structures respond to mechanical cues within their n…
View article: β1 Integrin–FAK–Piezo1 signalling axis drives<i>in-situ</i>stiffening mediated ECM remodelling and invasion of 3D breast epithelium
β1 Integrin–FAK–Piezo1 signalling axis drives<i>in-situ</i>stiffening mediated ECM remodelling and invasion of 3D breast epithelium Open
Stiffening of tissue is a hallmark of cancer progression, driving invasive phenotypes through complex interactions between cells and their extracellular matrix (ECM). However, the mechanisms linking mechanical cues to ECM remodelling and i…
View article: Influence of Emulsion Lipid Droplet Crystallinity on Postprandial Endotoxin Transporters and Atherogenic And Inflammatory Profiles in Healthy Men – A Randomized Double‐Blind Crossover Acute Meal Study
Influence of Emulsion Lipid Droplet Crystallinity on Postprandial Endotoxin Transporters and Atherogenic And Inflammatory Profiles in Healthy Men – A Randomized Double‐Blind Crossover Acute Meal Study Open
Scope Consumption of high‐fat meals is associated with increased endotoxemia, inflammation, and atherogenic profiles, with repeated postprandial responses suggested as contributors to chronically elevated risk factors. However, effects of …
View article: The effect of sprouted wheat wholemeal inclusion in bread recipes on postprandial blood glucose and satiety responses in healthy adults: a randomized trial
The effect of sprouted wheat wholemeal inclusion in bread recipes on postprandial blood glucose and satiety responses in healthy adults: a randomized trial Open
Sprouted wheat wholemeal was reported to enhance the nutritional and sensory properties of cereal products, but few human studies exist. The effect of blending 50 % sprouted wheat wholemeal in a bread recipe on the postprandial glycemic an…
View article: Orally consumed cannabinoids: the effect of carrier oil on acute tissue distribution in male C57BL/6 mice
Orally consumed cannabinoids: the effect of carrier oil on acute tissue distribution in male C57BL/6 mice Open
Background: Fundamental gaps in knowledge exist in understanding the tissue distribution of cannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC), following oral ingestion. CBD and THC are lipid-soluble and oral bioavailability is…
View article: The meat of the matter: plant-based meat analogue versus traditional meat product nutritional quality
The meat of the matter: plant-based meat analogue versus traditional meat product nutritional quality Open
Plant-based meat analogues (PBMA) are formulated to mimic the sensory characteristics of traditional meat products (TMP) using vegetarian ingredients and are increasingly popular with the trend towards plant-based diets, even among meat-ea…
View article: Lipid emulsion structure, digestion behavior, physiology, and health: a scoping review and future directions
Lipid emulsion structure, digestion behavior, physiology, and health: a scoping review and future directions Open
Research investigating the effects of the food matrix on health is needed to untangle many unresolved questions in nutritional science. Emulsion structure plays a fundamental role in this inquiry; however, the effects of oil-in-water emuls…
View article: Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach
Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach Open
Microrheology, the study of fluids on micron length-scales, promises to reveal insights into cellular biology, including mechanical biomarkers of disease and the interplay between biomechanics and cellular function. Here a minimally-invasi…
View article: Editorial: Novel delivery systems of flavors and essential oils: exploring potential health applications in foods
Editorial: Novel delivery systems of flavors and essential oils: exploring potential health applications in foods Open
EDITORIAL article Front. Nutr., 18 April 2023Sec. Nutrition and Food Science Technology Volume 10 - 2023 | https://doi.org/10.3389/fnut.2023.1183878
View article: Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML
Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML Open
In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contrib…
View article: Living Cells as a Biological Analog of Optical Tweezers -- a Non-Invasive Microrheology Approach
Living Cells as a Biological Analog of Optical Tweezers -- a Non-Invasive Microrheology Approach Open
Microrheology, the study of fluids on micron length-scales, promises to reveal insights into cellular biology, including mechanical biomarkers of disease and the interplay between biomechanics and cellular function. Here a minimally-invasi…
View article: Palm Lipid Emulsion Droplet Crystallinity and Gastric Acid Stability in Relation to in vitro Bioaccessibility and in vivo Gastric Emptying
Palm Lipid Emulsion Droplet Crystallinity and Gastric Acid Stability in Relation to in vitro Bioaccessibility and in vivo Gastric Emptying Open
It is poorly understood how the physical state of emulsified triacylglycerol (TAG) alters colloidal behavior in the gastrointestinal tract to modulate lipid digestion and absorption. We, therefore, aimed to investigate the individual and c…
View article: Effect of pH and heat treatment conditions on physicochemical and acid gelation properties of liquid milk protein concentrate
Effect of pH and heat treatment conditions on physicochemical and acid gelation properties of liquid milk protein concentrate Open
Milk protein concentrates (MPC) are typically dried high-protein powders with functional and nutritional properties that can be tailored through modification of processing conditions, including temperature, pH, filtration, and drying. Howe…
View article: Microrheology reveals microscale viscosity gradients in planktonic systems
Microrheology reveals microscale viscosity gradients in planktonic systems Open
Significance At the microscopic scales at which the life of marine microbes unfolds, the physics is dominated by viscosity. Increasing viscosity slows down both the passive transport of solutes and particles and the swimming of motile micr…
View article: Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells
Picosecond ultrasonics for elasticity-based imaging and characterization of biological cells Open
Characterization of the elasticity of biological cells is growing as a new way to gain insight into cell biology. Cell mechanics are related to most aspects of cellular behavior, and applications in research and medicine are broad. Current…
View article: LB001EFFICACY AND SAFETY OF BELIMUMAB IN PATIENTS WITH ACTIVE LUPUS NEPHRITIS: A PHASE 3, RANDOMISED, PLACEBO-CONTROLLED TRIAL
LB001EFFICACY AND SAFETY OF BELIMUMAB IN PATIENTS WITH ACTIVE LUPUS NEPHRITIS: A PHASE 3, RANDOMISED, PLACEBO-CONTROLLED TRIAL Open
Background and Aims Belimumab (BEL), an anti-B-cell-activating factor (BAFF) monoclonal antibody, is approved in patients (pts) ≥5 years of age with active systemic lupus erythematosus (SLE). Post hoc analyses of pooled renal outcomes data…
View article: Apple Flavonols Mitigate Adipocyte Inflammation and Promote Angiogenic Factors in LPS- and Cobalt Chloride-Stimulated Adipocytes, in Part by a Peroxisome Proliferator-Activated Receptor-γ-Dependent Mechanism
Apple Flavonols Mitigate Adipocyte Inflammation and Promote Angiogenic Factors in LPS- and Cobalt Chloride-Stimulated Adipocytes, in Part by a Peroxisome Proliferator-Activated Receptor-γ-Dependent Mechanism Open
Adipose tissue (AT) expansion induces local hypoxia, a key contributor to the chronic low-grade inflammation that drives obesity-associated disease. Apple flavonols phloretin (PT) and phlorizin (PZ) are suggested anti-inflammatory molecule…
View article: Characterization of anthocyanin‐containing purple wheat prototype products as functional foods with potential health benefits
Characterization of anthocyanin‐containing purple wheat prototype products as functional foods with potential health benefits Open
Background and objectives Purple wheat is relatively rich in anthocyanin and phenolic acid compounds that have demonstrated positive physiological effects in humans. This study was intended to develop purple wheat (PW) food prototypes with…
View article: Increased milk protein content and whey-to-casein ratio in milk served with breakfast cereal reduce postprandial glycemia in healthy adults: An examination of mechanisms of action
Increased milk protein content and whey-to-casein ratio in milk served with breakfast cereal reduce postprandial glycemia in healthy adults: An examination of mechanisms of action Open
This study describes the effects on glycemic response and the underlying mechanisms of action of increasing the protein concentration and decreasing the casein-to-whey ratio in milk when consumed with a high glycemic breakfast cereal. Twel…
View article: A Randomized Crossover Trial on the Effects of Whole Apple Consumption on Postprandial Response to an Oral Fat Tolerance Test in Overweight and Obese Individuals (P08-109-19)
A Randomized Crossover Trial on the Effects of Whole Apple Consumption on Postprandial Response to an Oral Fat Tolerance Test in Overweight and Obese Individuals (P08-109-19) Open
Postprandial lipemia (PPL) is a possible target for dietary strategies seeking to reduce cardiovascular disease (CVD) risk, including in overweight and obese individuals. Apples contain pectin and polyphenols that have shown potential to m…
View article: Effect of milk protein intake and casein-to-whey ratio in breakfast meals on postprandial glucose, satiety ratings, and subsequent meal intake
Effect of milk protein intake and casein-to-whey ratio in breakfast meals on postprandial glucose, satiety ratings, and subsequent meal intake Open
Whey and casein proteins differentially affect postprandial blood glucose and satiety mechanisms, with relevance for type 2 diabetes and obesity. Therefore, the purpose of this work was to investigate the effect of the casein-to-whey prote…