Amanda L. Paskavitz
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View article: A machine learning approach using semen parameters and sperm mitochondrial DNA copy number to predict couples’ fecundity
A machine learning approach using semen parameters and sperm mitochondrial DNA copy number to predict couples’ fecundity Open
Sperm mtDNAcn is associated with multiple conventional and detailed semen parameters. Moreover, a composite machine learning ElNet-SQI that included mtDNAcn and several semen parameters had the highest predictive ability of pregnancy. Thes…
View article: Urinary concentrations of phthalate and phthalate alternative metabolites and sperm DNA methylation: A multi-cohort and meta-analysis of men in preconception studies
Urinary concentrations of phthalate and phthalate alternative metabolites and sperm DNA methylation: A multi-cohort and meta-analysis of men in preconception studies Open
Phthalates are ubiquitous pollutants in the environment; however, the mechanisms of phthalate-associated reproductive disorders in men are not fully understood. The aim of this study is to investigate associations between urinary phthalate…
View article: Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome
Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome Open
Male fertility has been declining worldwide especially in countries with high levels of endocrine disrupting chemicals (EDCs). Per- and polyfluorinated alkyl Substances (PFAS) have been classified as EDCs and have been linked to adverse ma…
View article: Associations between Sperm Epigenetic Age and Semen Parameters: An Evaluation of Clinical and Non-Clinical Cohorts
Associations between Sperm Epigenetic Age and Semen Parameters: An Evaluation of Clinical and Non-Clinical Cohorts Open
The well-documented relationship between chronological age and the sperm methylome has allowed for the construction of epigenetic clocks that estimate the biological age of sperm based on DNA methylation, which we previously termed sperm e…
View article: $\\textbf{MyoMapNet}$: Accelerated Modified Look-Locker Inversion\n Recovery Myocardial T1 Mapping via Neural Networks
$\\textbf{MyoMapNet}$: Accelerated Modified Look-Locker Inversion\n Recovery Myocardial T1 Mapping via Neural Networks Open
Purpose: To develop and evaluate MyoMapNet, a rapid myocardial T1 mapping\napproach that uses neural networks (NN) to estimate voxel-wise myocardial T1\nand extracellular (ECV) from T1-weighted images collected after a single\ninversion pu…
View article: Differential expression of zinc transporters accompanies the differentiation of C2C12 myoblasts
Differential expression of zinc transporters accompanies the differentiation of C2C12 myoblasts Open
Zinc transporters facilitate metal mobilization and compartmentalization, playing a key role in cellular development. Little is known about the mechanisms and pathways of Zn movement between Zn transporters and metalloproteins during myobl…
View article: Dynamic changes in copper homeostasis and post-transcriptional regulation of<i>Atp7a</i>during myogenic differentiation
Dynamic changes in copper homeostasis and post-transcriptional regulation of<i>Atp7a</i>during myogenic differentiation Open
Copper (Cu) is an essential metal required for activity of a number of redox active enzymes that participate in critical cellular pathways such as metabolism and cell signaling.
View article: Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition
Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition Open
View article: Endogenous PGE2 Amplifies IL-33 Production By Macrophages through an EP2/EP4-cAMP-Epac-Dependent Pathway
Endogenous PGE2 Amplifies IL-33 Production By Macrophages through an EP2/EP4-cAMP-Epac-Dependent Pathway Open
View article: Comparative evaluation of iron leach from different sources of fly ash under atmospherically relevant conditions
Comparative evaluation of iron leach from different sources of fly ash under atmospherically relevant conditions Open
Environmental context Iron, a limiting nutrient of plankton in the ocean, is deposited to the sea from atmospheric aerosols. In particular, atmospheric acidic conditions promote dissolution of iron from fly ash, a by-product of coal-fired …