Adam Lam
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View article: Dietary impact on the gut resistome: western diet independently increases the prevalence of antibiotic resistance genes within the gut microbiota
Dietary impact on the gut resistome: western diet independently increases the prevalence of antibiotic resistance genes within the gut microbiota Open
Approximately half of surgical site infections are caused by pathogens resistant to the antibiotics used for prophylaxis. We recently demonstrated that when mice are fed a western diet (WD) that is high in fat and low in fiber, exposed to …
View article: Complete Pathologic Response of Squamous Cell Carcinoma Abutting an Internal Mammary Bypass Graft
Complete Pathologic Response of Squamous Cell Carcinoma Abutting an Internal Mammary Bypass Graft Open
We present a case of an advanced squamous cell carcinoma encroaching on a patient's left internal mammary artery bypass graft. Tumor board consensus was to proceed with 2 cycles of neoadjuvant chemotherapy followed by resection. Intraopera…
View article: Defining Microbiome Readiness for Surgery: Dietary Prehabilitation and Stool Biomarkers as Predictive Tools to Improve Outcome
Defining Microbiome Readiness for Surgery: Dietary Prehabilitation and Stool Biomarkers as Predictive Tools to Improve Outcome Open
Objectives: Determine whether preoperative dietary prehabilitation with a low-fat, high-fiber diet reverses the impact of Western diet (WD) on the intestinal microbiota and improves postoperative survival Background: We have previously dem…
View article: The role of medical technology in surgical innovation
The role of medical technology in surgical innovation Open
How can we achieve widespread adoption of surgical innovations into clinical practice quickly and frugally?
View article: Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema
Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema Open
Pulmonary fibrosis and emphysema are irreversible chronic events after inhalation injury. However, the mechanism(s) involved in their development remain poorly understood. Higher levels of plasma and lung heme have been recorded in acute l…
View article: Mechanisms and Treatment of Halogen Inhalation–Induced Pulmonary and Systemic Injuries in Pregnant Mice
Mechanisms and Treatment of Halogen Inhalation–Induced Pulmonary and Systemic Injuries in Pregnant Mice Open
Inhalation of oxidant gases has been implicated in adverse outcomes in pregnancy, but animal models to address mechanisms and studies to identify potential pregnancy-specific therapies are lacking. Herein, we show that inhalation of bromin…
View article: Role of apoptosis and autophagy in tuberculosis
Role of apoptosis and autophagy in tuberculosis Open
Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB infections dating back to 5,800 b.c. TB is unique in its ability to …
View article: Chlorine‐induced cardiopulmonary injury
Chlorine‐induced cardiopulmonary injury Open
Chlorine (Cl 2 ) is utilized worldwide for a diverse range of industrial applications, including pulp bleaching, sanitation, and pharmaceutical development. Though Cl 2 has widespread use, little is known regarding the mechanisms of toxici…
View article: Role of heme in bromine‐induced lung injury
Role of heme in bromine‐induced lung injury Open
Bromine (Br 2 ) gas inhalation poses an environmental and occupational hazard resulting in high morbidity and mortality. In this review, we underline the acute lung pathology (within 24 h of exposure) and potential therapeutic intervention…