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View article: Decentralized Biobanking Pathway to Precision Medicine: Futures Study
Decentralized Biobanking Pathway to Precision Medicine: Futures Study Open
Background Biobank privacy policies remove identifiers from donated specimens, siloing patients, discounting multimodal data, and hindering precision medicine. Decentralized biobanking is a new paradigm that unlocks value by uniting patien…
View article: Decentralized Biobanking for the Future of Precision Medicine (Preprint)
Decentralized Biobanking for the Future of Precision Medicine (Preprint) Open
BACKGROUND Biobank privacy policies remove identifiers from donated specimens, siloing patients, discounting multi-modal data, and hindering precision medicine. Decentralized biobanking is a new paradigm that unlocks value by uniting pati…
View article: Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas Open
Glioblastoma (GBM), an incurable tumor, remains difficult to model and more importantly to treat due to its genetic/epigenetic heterogeneity and plasticity across cellular states. The ability of current tumor models to recapitulate the cel…
View article: Supplementary Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
Supplementary Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas Open
Supplementary figures and tables with Figure legends.
View article: Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas Open
Glioblastoma (GBM), an incurable tumor, remains difficult to model and more importantly to treat due to its genetic/epigenetic heterogeneity and plasticity across cellular states. The ability of current tumor models to recapitulate the cel…
View article: Supplementary Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
Supplementary Data from Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas Open
Supplementary figures and tables with Figure legends.
View article: Organoids as a Systems Platform for SCLC Brain Metastasis
Organoids as a Systems Platform for SCLC Brain Metastasis Open
Small Cell Lung Cancer (SCLC) is a highly aggressive, neuroendocrine tumor. Traditional reductionist approaches have proven ineffective to ameliorate the uniformly dismal outcomes for SCLC – survival at 5 years remains less than 5%. A majo…
View article: Generating Patient-Derived Gliomas within Cerebral Organoids
Generating Patient-Derived Gliomas within Cerebral Organoids Open
Glioblastoma (GBM) remains a devastating disease with a median survival of less than two years. Current preclinical models are unable to accurately reflect the complexity of human GBM. We recently established a cerebral organoid glioma (GL…
View article: Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas
Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas Open
Glioblastoma (GBM), an incurable tumor, remains difficult to model and more importantly to treat due to its genetic/epigenetic heterogeneity and plasticity across cellular states. The ability of current tumor models to recapitulate the cel…
View article: Modeling Patient-Derived Glioblastoma with Cerebral Organoids
Modeling Patient-Derived Glioblastoma with Cerebral Organoids Open
The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a "normal" human microenvironment and the inability of many tumo…
View article: Detailed longitudinal sampling of glioma stem cells <i>in situ</i> reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence
Detailed longitudinal sampling of glioma stem cells <i>in situ</i> reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence Open
Intratumoral heterogeneity at the genetic, epigenetic, transcriptomic, and morphologic levels is a commonly observed phenomenon in many aggressive cancer types. Clonal evolution during tumor formation and in response to therapeutic interve…
View article: A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity
A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity Open
Glioblastoma, the most common primary malignant brain tumor, harbors a small population of tumor initiating cells (glioblastoma stem cells) that have many properties similar to neural stem cells. To investigate common regulatory networks i…