Amanda Lyons
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View article: Considerations for healthcare wastewater surveillance of targeted antimicrobial-resistant organisms
Considerations for healthcare wastewater surveillance of targeted antimicrobial-resistant organisms Open
Wastewater surveillance (WWS) at healthcare facilities paired with CDC- recommended patient screening methods may enable earlier detection of targeted antimicrobial resistant (AR) pathogens. However, this is a nascent field with knowledge …
View article: In Vitro Activity of Novel Topoisomerase Inhibitors against Francisella tularensis and Burkholderia pseudomallei
In Vitro Activity of Novel Topoisomerase Inhibitors against Francisella tularensis and Burkholderia pseudomallei Open
Antimicrobial resistance is a global issue, and the investigation of alternative therapies that are not traditional antibiotics are warranted. Novel bacterial type II topoisomerase inhibitors (NBTIs) have recently emerged as a novel class …
View article: Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2
Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2 Open
We disclose the discovery of REDX07965, a novel tricyclic topoisomerase inhibitor (NTTI) which has broad spectrum activity, favourable in vitro pharmacokinetic properties and selectivity versus human topoisomerase II.