Amanda M. Eudy
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View article: Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials
Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials Open
OBJECTIVE: To characterize hydroxychloroquine (HCQ) exposure in patients with rheumatic disease receiving longterm HCQ compared to target concentrations with reported antiviral activity against the coronavirus disease 2019 caused by SARS-C…
View article: A NOVEL MODELING APPROACH TO ELUCIDATE THE ROLE OF AUTOANTIBODIES IN COMPLEMENT ACTIVATION IN SLE
A NOVEL MODELING APPROACH TO ELUCIDATE THE ROLE OF AUTOANTIBODIES IN COMPLEMENT ACTIVATION IN SLE Open
PV228 / #365 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose In SLE, autoantibodies (ANAs) can promote pathogenesis by forming immune complexes (ICs) that activate complement. While antibodies to DNA (anti…
View article: SOCIAL DRIVERS OF HEALTH IN A LARGE ACADEMIC LUPUS CLINIC
SOCIAL DRIVERS OF HEALTH IN A LARGE ACADEMIC LUPUS CLINIC Open
PV097a / #117 Poster Topic: AS11 - Epidemiology and Public Health Background/Purpose Adverse social drivers of health (SDoH) in systemic lupus erythematosus (SLE) are associated with worse health outcomes and quality of life. The aim of th…
View article: CHARACTERISTICS OF PATIENTS WITH INTERMITTENT AND PERSISTENT TYPE 2 SLE
CHARACTERISTICS OF PATIENTS WITH INTERMITTENT AND PERSISTENT TYPE 2 SLE Open
PV207 / #177 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose Our prior qualitative work demonstrated there are at least 2 distinct subgroups of Type 2 SLE; one is related to active inflammation (Intermitte…
View article: THE ASSOCIATION BETWEEN TRAUMA AND QUALITY OF LIFE IN SLE.
THE ASSOCIATION BETWEEN TRAUMA AND QUALITY OF LIFE IN SLE. Open
PV233 / #350 Poster Topic: AS23 - SLE-Diagnosis, Manifestations, & Outcomes Background/Purpose In SLE, early childhood trauma and adverse childhood experiences have been associated with chronic pain, fatigue, depression, self-reported flar…
View article: A PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN PLASMA MICROBIAL CELL-FREE DNA AND DISEASE ACTIVITY IN PATIENTS WITH LUPUS
A PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN PLASMA MICROBIAL CELL-FREE DNA AND DISEASE ACTIVITY IN PATIENTS WITH LUPUS Open
PT001 / #268 Topic: AS04 - Biomarkers POSTER TOUR 02: RECENT INSIGHTS ON THE PATHOGENESIS OF LUPUS NEPHRITIS 23-05-2025 10:00 AM - 10:40 AM Background/Purpose Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized…
View article: Nociplasticity: A Proposed Concept to Understand the Symptomatology of Systemic Lupus Erythematosus
Nociplasticity: A Proposed Concept to Understand the Symptomatology of Systemic Lupus Erythematosus Open
View article: Second Trimester Kidney Function and Adverse Pregnancy Outcomes among Patients with Lupus
Second Trimester Kidney Function and Adverse Pregnancy Outcomes among Patients with Lupus Open
Key Points In our combined cohort, second trimester kidney function was associated with adverse outcomes for patients with lupus. Measurement of kidney function during pregnancy may have potential benefit, especially among patients without…
View article: Prevalence and correlates of restricted community mobility in a population-based cohort of adults with systemic lupus erythematosus
Prevalence and correlates of restricted community mobility in a population-based cohort of adults with systemic lupus erythematosus Open
Objective Restrictions in community mobility, defined as the frequency of and help required to travel to ‘life-spaces’ (bedroom, home, yard, neighbourhood and town), are associated with poor outcomes among older adults. We aimed to describ…
View article: Relationship between hydroxychloroquine blood levels and lupus activity through the lens of the type 1 and type 2 lupus model: a cross-sectional study
Relationship between hydroxychloroquine blood levels and lupus activity through the lens of the type 1 and type 2 lupus model: a cross-sectional study Open
Introduction In the type 1 and 2 SLE model, inflammation mediates type 1 manifestations, but its role in type 2 manifestations (eg, fatigue, myalgias, mood disturbance, cognitive dysfunction) is less clear. Therapeutic hydroxychloroquine (…
View article: Perspectives of Rheumatologists on the Type 1 and 2 Systemic Lupus Erythematosus Model
Perspectives of Rheumatologists on the Type 1 and 2 Systemic Lupus Erythematosus Model Open
Objective The Type 1 and 2 systemic lupus erythematosus (SLE) Model was developed to encapsulate all signs and symptoms that patients with SLE experience. Our previous qualitative work demonstrated the model accurately reflects the lived e…
View article: The Impact of Pregnancy Readiness on Lupus Activity, Maternal Mental Health, and Pregnancy Outcomes
The Impact of Pregnancy Readiness on Lupus Activity, Maternal Mental Health, and Pregnancy Outcomes Open
Objective Among individuals with systemic lupus erythematosus (SLE) who became pregnant, we explored the impact of medical readiness for pregnancy and personal readiness for pregnancy on the following aspects of maternal health: (1) provid…
View article: Using linked electronic medical record-pharmacy data to examine lupus medication adherence: A retrospective cohort study
Using linked electronic medical record-pharmacy data to examine lupus medication adherence: A retrospective cohort study Open
Introduction Medication nonadherence is common in systemic lupus erythematosus (SLE) and associated with morbidity and mortality. We explored the reliability of pharmacy data within the electronic medical record (EMR) to examine factors as…
View article: 303 Clinical and laboratory associations of longitudinal cell-bound complement activation products in SLE
303 Clinical and laboratory associations of longitudinal cell-bound complement activation products in SLE Open
Introduction Cell-bound complement activation products (CB-CAPs) in a multi-analyte assay with algorithm (MAP) is a valuable biomarker for the diagnosis of SLE. Erythrocyte-bound complement activation products have been associated with SLE…
View article: 602 The role of active nephritis, compared to active non-renal SLE, in pregnancy outcomes
602 The role of active nephritis, compared to active non-renal SLE, in pregnancy outcomes Open
Purpose We sought to determine whether the type of SLE activity, particularly lupus nephritis compared to non-renal SLE activity, determined the level of pregnancy risk. Methods All pregnancies in women with SLE enrolled Results Of 115 pre…
View article: 1402 Embracing a biopsychosocial approach to type 2 SLE: insights from the type 2 SLE consortium
1402 Embracing a biopsychosocial approach to type 2 SLE: insights from the type 2 SLE consortium Open
Background Patients with SLE experience distressing fibromyalgia-like symptoms of fatigue, widespread pain, mood disturbance, and brain fog that negatively impact quality of life and are challenging to manage. These symptoms, termed Type 2…
View article: 605 Patterns of type 1 & type 2 systemic lupus erythematosus activity
605 Patterns of type 1 & type 2 systemic lupus erythematosus activity Open
Disclosures AME, JLR, MEBC: Exagen, Immunovant Funding Duke CTSA grant (UL1TR002553) Background The Type 1 & 2 SLE Model encompass symptoms classically attributed to inflammation, including arthritis, rash, serositis and neph…
View article: Interpreting hydroxychloroquine blood levels for medication non-adherence: a pharmacokinetic study
Interpreting hydroxychloroquine blood levels for medication non-adherence: a pharmacokinetic study Open
Objective Characterise the relationship between hydroxychloroquine (HCQ) blood levels and the number of missed doses, accounting for dosage, dose timing and the large variability in pharmacokinetics (PK) between patients. Methods We extern…
View article: The Type 1 & 2 systemic lupus erythematosus model: Perspectives of people living with systemic lupus erythematosus
The Type 1 & 2 systemic lupus erythematosus model: Perspectives of people living with systemic lupus erythematosus Open
Objective In the new Type 1 & 2 model for systemic lupus erythematosus (SLE), Type 1 SLE represents classic inflammatory manifestations, such as arthritis, while Type 2 SLE encompasses symptoms such as pain and fatigue where the relationsh…
View article: A qualitative study of facilitators of medication adherence in systemic lupus erythematosus: Perspectives from rheumatology providers/staff and patients
A qualitative study of facilitators of medication adherence in systemic lupus erythematosus: Perspectives from rheumatology providers/staff and patients Open
Objective Systemic lupus erythematosus (SLE) disproportionately affects patients from racial and ethnic minority groups. Medication adherence is lower among these patient populations, and nonadherence is associated with worse health outcom…
View article: Azathioprine metabolite levels and outcomes during pregnancies with rheumatic disease
Azathioprine metabolite levels and outcomes during pregnancies with rheumatic disease Open
Objective Despite widespread use of azathioprine (AZA) during pregnancy, no studies evaluated the impact of pregnancy on AZA metabolites 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine nucleotide (6-MMPN) disposition in rheumat…
View article: Using PROMIS-29 to determine symptom burdens in the context of the Type 1 and 2 systemic lupus erythematosus (SLE) model: a cross sectional study
Using PROMIS-29 to determine symptom burdens in the context of the Type 1 and 2 systemic lupus erythematosus (SLE) model: a cross sectional study Open
View article: Patient and Physician Perspectives of Systemic Lupus Erythematosus Flare: A Qualitative Study
Patient and Physician Perspectives of Systemic Lupus Erythematosus Flare: A Qualitative Study Open
Objective Systemic lupus erythematosus (SLE) flares are associated with increased damage and decreased health-related quality of life. We hypothesized that there is discordance between physicians’ and patients’ views of SLE flare. In this …
View article: Development and psychometric evaluation of a physician global assessment for type 2 systemic lupus erythematosus symptoms
Development and psychometric evaluation of a physician global assessment for type 2 systemic lupus erythematosus symptoms Open
Objective Manifestations of SLE can be categorised as type 1 (classic signs and symptoms of SLE) or type 2 (fatigue, widespread pain and brain fog with an unclear relationship to inflammation). While measures of type 1 SLE activity exist, …
View article: Gestational weight gain in women with systemic lupus erythematosus
Gestational weight gain in women with systemic lupus erythematosus Open
Objective The objective of this study was to estimate the proportion of pregnant women with systemic lupus erythematosus meeting Institute of Medicine guidelines for gestational weight gain and determine correlates of adherence to guidelin…
View article: Preconceptional cardiovascular health and pregnancy outcomes in women with systemic lupus erythematosus
Preconceptional cardiovascular health and pregnancy outcomes in women with systemic lupus erythematosus Open
Objective. To estimate the effects of preconceptional cardiovascular (CV) health, measured by American Heart Association (AHA) guidelines, on pregnancy outcomes in women with systemic lupus erythematosus (SLE). Methods. The study included …
View article: Implications of the accuracy of diagnostic algorithms for systemic lupus on our understanding of racial disparities in pregnancy outcomes
Implications of the accuracy of diagnostic algorithms for systemic lupus on our understanding of racial disparities in pregnancy outcomes Open
Objective Disparities in pregnancy outcomes among women with SLE remain understudied, with few available racially diverse datasets. We sought to identify disparities between Black and White women in pregnancy outcomes within academic insti…
View article: Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone
Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone Open
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled rec…
View article: Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone
Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone Open
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled rec…
View article: Development and Initial Validation of a Systemic Lupus Erythematosus–Specific Measure of the Extent of and Reasons for Medication Nonadherence
Development and Initial Validation of a Systemic Lupus Erythematosus–Specific Measure of the Extent of and Reasons for Medication Nonadherence Open