Amanda M. Maple
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View article: Two single arm trials of AKL-T01, a digital therapeutic for adolescents and adults with ADHD
Two single arm trials of AKL-T01, a digital therapeutic for adolescents and adults with ADHD Open
Inattention symptoms represent a key driver of functional impairment in ADHD and often persist into adolescence and adulthood, underscoring a need for novel treatments targeting attentional control. We evaluated AKL-T01—a digital therapeut…
View article: Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene <i>Egr3</i>
Sleep deprivation rapidly upregulates serotonin 2A receptor expression via the immediate early gene <i>Egr3</i> Open
Serotonin 2A receptors (5-HT 2A Rs) mediate the effects of hallucinogenic drugs and antipsychotic medications, and are reduced in schizophrenia patients’ brains. However, the mechanisms that regulate 5-HT 2A R expression remain poorly unde…
View article: Influence of Schizophrenia-Associated Gene <i>Egr3</i> on Sleep Behavior and Circadian Rhythms in Mice
Influence of Schizophrenia-Associated Gene <i>Egr3</i> on Sleep Behavior and Circadian Rhythms in Mice Open
Up to 80% of people meeting DSM-IV definitions for schizophrenia will exhibit difficulties with sleep, along with a breakdown in circadian entrainment and rhythmicity. The changes to the sleep and circadian systems in this population are t…
View article: Attenuated Late-Phase<i>Arc</i>Transcription in the Dentate Gyrus of Mice Lacking<i>Egr3</i>
Attenuated Late-Phase<i>Arc</i>Transcription in the Dentate Gyrus of Mice Lacking<i>Egr3</i> Open
The dentate gyrus (DG) engages in sustained Arc transcription for at least 8 hours following behavioral induction, and this time course may be functionally coupled to the unique role of the DG in hippocampus-dependent learning and memory. …