Amanda E. Nelson
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View article: Metabolomic Signatures of Physical Function and Functional Trajectories in Older Adults: Insights from the ENRGISE Clinical Trial
Metabolomic Signatures of Physical Function and Functional Trajectories in Older Adults: Insights from the ENRGISE Clinical Trial Open
Background: Chronic inflammation contributes to functional decline in older adults, yet interventions targeting inflammatory pathways have shown inconsistent results. Metabolomics offers a promising approach to identify biological heteroge…
View article: Cam morphology and the risk of developing radiographic hip osteoarthritis within 8 years: an individual participant data meta-analysis of 23 886 hips from the world COACH consortium
Cam morphology and the risk of developing radiographic hip osteoarthritis within 8 years: an individual participant data meta-analysis of 23 886 hips from the world COACH consortium Open
Objective To assess the relationship between cam morphology and the development of radiographic hip osteoarthritis (RHOA), overall and in subgroups based on age, biological sex and body mass index (BMI). Methods Hips with no RHOA at baseli…
View article: Severe pincer morphology is associated with incident hip osteoarthritis: prospective individual participant data from 18 935 hips from the World COACH consortium
Severe pincer morphology is associated with incident hip osteoarthritis: prospective individual participant data from 18 935 hips from the World COACH consortium Open
Objective To assess the relationship between pincer morphology and incident radiographic hip osteoarthritis (RHOA) and study-specific subgroups. Methods Hips completely free of RHOA at baseline and with follow-up within 4–8 years were draw…
View article: Cross-sectional associations of radiographic multiple joint osteoarthritis and symptoms, laboratory values and the gut microbiota: A multimodal study in humans and pet dogs
Cross-sectional associations of radiographic multiple joint osteoarthritis and symptoms, laboratory values and the gut microbiota: A multimodal study in humans and pet dogs Open
These two cohorts demonstrated remarkably similar frequencies of rMJOA (∼20 %), supporting the use of dogs to model naturally occurring MJOA. Taxa potentially related to rMJOA and pain were identified in this preliminary analysis, providi…
View article: Identification of idiopathic inflammatory myopathy research cohorts using international classification of disease (ICD) codes: A systematic review
Identification of idiopathic inflammatory myopathy research cohorts using international classification of disease (ICD) codes: A systematic review Open
ICD coding is a valuable tool for identifying cases in bioinformatic research. Only a few studies describe ICD code validation for IIM research cohort construction. The highest PPV's are reported for DM and PM with the use of multiple codi…
View article: Hip morphology‐based osteoarthritis risk prediction models: development and external validation using individual participant data from the World COACH Consortium
Hip morphology‐based osteoarthritis risk prediction models: development and external validation using individual participant data from the World COACH Consortium Open
OBJECTIVES: This study aims to develop hip morphology-based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different popu…
View article: Hip morphology‐based osteoarthritis risk prediction models: development and external validation using individual participant data from the World <scp>COACH</scp> Consortium
Hip morphology‐based osteoarthritis risk prediction models: development and external validation using individual participant data from the World <span>COACH</span> Consortium Open
Objectives This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different popul…
View article: Utilization of Rehabilitation Services After Idiopathic Inflammatory Myopathy Diagnosis: A Retrospective Cohort Assessment in the United States
Utilization of Rehabilitation Services After Idiopathic Inflammatory Myopathy Diagnosis: A Retrospective Cohort Assessment in the United States Open
Objective To investigate utilization and timing of rehabilitation services for patients with idiopathic inflammatory myopathies (IIM). Methods This was a retrospective analysis of US patients in the TriNetX dataset. Patients were defined b…
View article: Applying binary mixed model to predict knee osteoarthritis pain
Applying binary mixed model to predict knee osteoarthritis pain Open
Data used to understand knee osteoarthritis (KOA) often involves knee-level, rather than person-level information. Failure to account for the correlation between joints within a person may lead to inaccurate inferences. The aim of this stu…
View article: How feasible is the stratification of osteoarthritis phenotypes by means of artificial intelligence?
How feasible is the stratification of osteoarthritis phenotypes by means of artificial intelligence? Open
Osteoarthritis (OA) is a common and serious disease that involves all of the tissues of an affected joint (e.g., cartilage, bone, meniscus, tendon/ligament, synovium) and can affect one or multiple joints in an individual person, most ofte…
View article: Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative
Identifying trajectories of joint space width loss among previously injured knees: Data from the Osteoarthritis Initiative Open
Objectives To identify trajectories of joint space width loss, a proxy measure of tibiofemoral cartilage loss, among previously injured knees. To describe the relationship of trajectory groups with sociodemographic and clinical risk factor…
View article: Narrative review of machine learning in rheumatic and musculoskeletal diseases for clinicians and researchers: biases, goals, and future directions
Narrative review of machine learning in rheumatic and musculoskeletal diseases for clinicians and researchers: biases, goals, and future directions Open
There has been rapid growth in the use of artificial intelligence (AI) analytics in medicine in recent years, including in rheumatic and musculoskeletal diseases (RMDs). Such methods represent a challenge to clinicians, patients, and resea…
View article: Clinical significance and diagnostic approach for paediatric unilateral tonsillar enlargement: insights from a retrospective analysis
Clinical significance and diagnostic approach for paediatric unilateral tonsillar enlargement: insights from a retrospective analysis Open
We recommend active monitoring of asymptomatic isolated UTE. Diagnostic tonsillectomy should be performed in patients with UTE and cervical lymphadenopathy and/or constitutional symptoms and/or altered tonsillar appearance.
View article: Exploring associations among pro-inflammatory cytokines, osteoarthritis, and gut microbiome composition in individuals with obesity using machine learning
Exploring associations among pro-inflammatory cytokines, osteoarthritis, and gut microbiome composition in individuals with obesity using machine learning Open
Three of five identified enterotypes were inversely associated with OA status and levels of OA associated cytokines. These exploratory analyses revealed associations between the gut microbiome, cytokines, and OA outcomes, suggesting potent…
View article: Effects of mental imagery training on cognitive function and brain connectivity in people with Parkinson’s disease: A randomized pilot trial
Effects of mental imagery training on cognitive function and brain connectivity in people with Parkinson’s disease: A randomized pilot trial Open
Cognitive impairment is a debilitating problem in Parkinson’s disease (PD) with no effective treatment. We developed a personalized mental imagery (MI) intervention focusing on goal-directed activities and examined its effect on everyday c…
View article: Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross‐Sectional Results From a Large Community‐Based Cohort
Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross‐Sectional Results From a Large Community‐Based Cohort Open
Objective Our study objectives were (1) to determine associations among ultrasound (US) features of knee osteoarthritis (KOA), radiographic KOA (rKOA), and patient‐reported symptoms and (2) to determine diagnostic accuracy of US definition…
View article: Optimizing osteoarthritis care through clinical and community partnership: Results of an exploratory trial
Optimizing osteoarthritis care through clinical and community partnership: Results of an exploratory trial Open
Feasibility metrics were positive, but effects of OA CARE were modest, and a more intensive approach may be needed to enhance impacts.
View article: Features of Knee and Multijoint Osteoarthritis by Sex and Race and Ethnicity: A Preliminary Analysis in the Johnston County Health Study.
Features of Knee and Multijoint Osteoarthritis by Sex and Race and Ethnicity: A Preliminary Analysis in the Johnston County Health Study. Open
OBJECTIVE: To evaluate knee osteoarthritis (KOA) and multijoint osteoarthritis (MJOA), and to compare features by sex and race and ethnicity in a population-based cohort. METHODS: Participants (n = 544) enrolled in the Johnston County Heal…
View article: Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium
Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium Open
AD was consistently associated with incident RHOA. Explorative analyses show that AD hips in women and age group 61-70 years seem to be more at risk of developing RHOA compared to non-AD hips.