Amanda R. Smith
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View article: Should Leading Causes Be Leading Solutions? Integrating Chronic Disease Surveillance into Data Modernization Efforts
Should Leading Causes Be Leading Solutions? Integrating Chronic Disease Surveillance into Data Modernization Efforts Open
Context: Chronic diseases are leading causes of death and disability in the United States and have disproportionate impacts in our communities due to demographic, geographic, and socioeconomic factors that affect health outcomes. Limitatio…
View article: Understanding community resilience during the drinking water contamination event on Oahu, Hawaii, 2021–2022: a mixed mode approach
Understanding community resilience during the drinking water contamination event on Oahu, Hawaii, 2021–2022: a mixed mode approach Open
View article: Sustained Performance of Cardiac Arrest Prevention in Pediatric Cardiac Intensive Care Units
Sustained Performance of Cardiac Arrest Prevention in Pediatric Cardiac Intensive Care Units Open
Importance The Pediatric Cardiac Critical Care Consortium (PC4) cardiac arrest prevention (CAP) quality improvement (QI) project facilitated a decreased in-hospital cardiac arrest (IHCA) incidence rate across multiple hospitals. The sustai…
View article: Community health impacts after a jet fuel leak contaminated a drinking water system: Oahu, Hawaii, November 2021
Community health impacts after a jet fuel leak contaminated a drinking water system: Oahu, Hawaii, November 2021 Open
Background: In 2021, a large petroleum leak contaminated a water source that supplied drinking water to military and civilians in Oahu, Hawaii. Methods: We conducted an Assessment of Chemical Exposures (ACE) survey and supplemented that in…
View article: COVID-19 pandemic–associated changes in overall emergency department visits by age group, race, and ethnicity — United States, January 2019–April 2022
COVID-19 pandemic–associated changes in overall emergency department visits by age group, race, and ethnicity — United States, January 2019–April 2022 Open
View article: Preventing Cardiac Arrest in the Pediatric Cardiac Intensive Care Unit Through Multicenter Collaboration
Preventing Cardiac Arrest in the Pediatric Cardiac Intensive Care Unit Through Multicenter Collaboration Open
Importance Preventing in-hospital cardiac arrest (IHCA) likely represents an effective strategy to improve outcomes for critically ill patients, but feasibility of IHCA prevention remains unclear. Objective To determine whether a low-techn…
View article: Trends in Acute Hepatitis of Unspecified Etiology and Adenovirus Stool Testing Results in Children — United States, 2017–2022
Trends in Acute Hepatitis of Unspecified Etiology and Adenovirus Stool Testing Results in Children — United States, 2017–2022 Open
In November 2021, CDC was notified of a cluster of previously healthy children with hepatitis of unknown etiology evaluated at a single U.S. hospital (1). On April 21, 2022, following an investigation of this cluster and reports of similar…
View article: <i>Notes from the Field:</i> Self-Reported Health Symptoms Following Petroleum Contamination of a Drinking Water System — Oahu, Hawaii, November 2021–February 2022
<i>Notes from the Field:</i> Self-Reported Health Symptoms Following Petroleum Contamination of a Drinking Water System — Oahu, Hawaii, November 2021–February 2022 Open
View article: <b>Changes and Inequities in Adult Mental Health–Related Emergency Department Visits During the COVID-19 Pandemic in the US</b>
<b>Changes and Inequities in Adult Mental Health–Related Emergency Department Visits During the COVID-19 Pandemic in the US</b> Open
Results of this cross-sectional study suggest that EDs may have increases in MH-related visits after COVID-19 surges, specifically for young adults and individual racial and ethnic minoritized subpopulations. Public health practitioners sh…
View article: Pediatric Emergency Department Visits Before and During the COVID-19 Pandemic — United States, January 2019–January 2022
Pediatric Emergency Department Visits Before and During the COVID-19 Pandemic — United States, January 2019–January 2022 Open
Emergency departments (EDs) in the United States remain a frontline resource for pediatric health care emergencies during the COVID-19 pandemic; however, patterns of health-seeking behavior have changed during the pandemic (1,2). CDC exami…
View article: Pediatric Emergency Department Visits Associated with Mental Health Conditions Before and During the COVID-19 Pandemic — United States, January 2019–January 2022
Pediatric Emergency Department Visits Associated with Mental Health Conditions Before and During the COVID-19 Pandemic — United States, January 2019–January 2022 Open
In 2021, a national emergency* for children's mental health was declared by several pediatric health organizations, and the U.S. Surgeon General released an advisory† on mental health among youths. These actions resulted from on…
View article: Extensively Drug-Resistant Carbapenemase-Producing <i>Pseudomonas aeruginosa</i> and Medical Tourism from the United States to Mexico, 2018–2019
Extensively Drug-Resistant Carbapenemase-Producing <i>Pseudomonas aeruginosa</i> and Medical Tourism from the United States to Mexico, 2018–2019 Open
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) producing the Verona integron‒encoded metallo-β-lactamase (VIM) are highly antimicrobial drug-resistant pathogens that are uncommon in the United States. We investigated the source of VIM-…
View article: Emergency Department Visits for COVID-19 by Race and Ethnicity — 13 States, October–December 2020
Emergency Department Visits for COVID-19 by Race and Ethnicity — 13 States, October–December 2020 Open
Hispanic or Latino (Hispanic), non-Hispanic Black or African American (Black), and non-Hispanic American Indian or Alaska Native (AI/AN) persons have experienced disproportionately higher rates of hospitalization and death attributable to …
View article: Changes in Seasonal Respiratory Illnesses in the United States During the Coronavirus Disease 2019 (COVID-19) Pandemic
Changes in Seasonal Respiratory Illnesses in the United States During the Coronavirus Disease 2019 (COVID-19) Pandemic Open
Background Respiratory tract infections are common, often seasonal, and caused by multiple pathogens. We assessed whether seasonal respiratory illness patterns changed during the COVID-19 pandemic. Methods We categorized emergency departme…
View article: Low SARS-CoV-2 Transmission in Elementary Schools — Salt Lake County, Utah, December 3, 2020–January 31, 2021
Low SARS-CoV-2 Transmission in Elementary Schools — Salt Lake County, Utah, December 3, 2020–January 31, 2021 Open
School closures affected more than 55 million students across the United States when implemented as a strategy to prevent the transmission of SARS-CoV-2, the virus that causes COVID-19 (1). Reopening schools requires balancing the risks fo…
View article: Infection control response to an outbreak of OXA-23 carbapenemase-producing carbapenem-resistant Acinetobacter baumannii in a skilled nursing facility in Utah
Infection control response to an outbreak of OXA-23 carbapenemase-producing carbapenem-resistant Acinetobacter baumannii in a skilled nursing facility in Utah Open
View article: Changing US Epidemiology of NDM-Producing Carbapenem-Resistant Enterobacteriaceae, 2017–2019
Changing US Epidemiology of NDM-Producing Carbapenem-Resistant Enterobacteriaceae, 2017–2019 Open
Background: Due to limited therapeutic options and potential for spread, carbapenem-resistant Enterobacteriaceae (CRE)-producing New Delhi metallo-β-lactamases (NDMs) are a public health priority. We investigated the epidemiology of NDM-pr…
View article: Recent Increase in COVID-19 Cases Reported Among Adults Aged 18–22 Years — United States, May 31–September 5, 2020
Recent Increase in COVID-19 Cases Reported Among Adults Aged 18–22 Years — United States, May 31–September 5, 2020 Open
Although children and young adults are reportedly at lower risk for severe disease and death from infection with SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), than are persons in other age groups (1), younger perso…
View article: Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent <scp>d</scp> -peptide HIV entry inhibitor
Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent <span>d</span> -peptide HIV entry inhibitor Open
Significance This paper characterizes a d -peptide HIV entry inhibitor, CPT31, in rhesus macaques. This nonhuman primate animal model provides the most robust evaluation of an in vivo antiviral prior to human trials. As described here, CPT…
View article: Prevention and Treatment of SHIVAD8 Infection in Rhesus Macaques by a Potent D-peptide HIV Entry Inhibitor
Prevention and Treatment of SHIVAD8 Infection in Rhesus Macaques by a Potent D-peptide HIV Entry Inhibitor Open
Cholesterol-PIE12-trimer (CPT31) is a potent D-peptide HIV entry inhibitor that targets the highly conserved gp41 N-peptide pocket region. CPT31 exhibited strong inhibitory breadth against diverse panels of primary virus isolates. In a SHI…
View article: Characterization of resistance to a potent D-peptide HIV entry inhibitor
Characterization of resistance to a potent D-peptide HIV entry inhibitor Open
Background PIE12-trimer is a highly potent D-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved hydrophobic pockets at the base of the gp41 N-trimer with sub-femtomolar …
View article: Nursing Implications in the ECMO Patient
Nursing Implications in the ECMO Patient Open
Effective care and positive outcomes of the extracorporeal membrane oxygenation (ECMO) patient necessitate optimal interdisciplinary management from the healthcare team, including expert care from specially trained registered nurses (RNs).…
View article: Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source — Multiple States, 2018
Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source — Multiple States, 2018 Open
During May-October 2018, four patients from three states experienced sepsis after transfusion of apheresis platelets contaminated with Acinetobacter calcoaceticus-baumannii complex (ACBC) and Staphylococcus saprophyticus; one patient died.…
View article: <i>Notes from the Field:</i>Verona Integron-Encoded Metallo-β-Lactamase–Producing Carbapenem-Resistant<i>Pseudomonas aeruginosa</i>Infections in U.S. Residents Associated with Invasive Medical Procedures in Mexico, 2015–2018
<i>Notes from the Field:</i>Verona Integron-Encoded Metallo-β-Lactamase–Producing Carbapenem-Resistant<i>Pseudomonas aeruginosa</i>Infections in U.S. Residents Associated with Invasive Medical Procedures in Mexico, 2015–2018 Open
View article: Integrated and Open Interpreter Education: The Open Educational Resource Reader and Workbook for Interpreters
Integrated and Open Interpreter Education: The Open Educational Resource Reader and Workbook for Interpreters Open
This poster depicts the development of an OER for interpreting educators by Western Oregon University Interpreting Studies faculty, as well as the collaboration with the University Library to publish the final product. The goal of the OER …
View article: MOESM1 of Characterization of resistance to a potent d-peptide HIV entry inhibitor
MOESM1 of Characterization of resistance to a potent d-peptide HIV entry inhibitor Open
Additional file 1. Mutations observed in PIE12-trimer resistant viral pools. Env gene position (pNL4-3 numbering), reference base, and all base calls for control and PIE12-trimer resistance viral populations with a mutation > 10% of the po…
View article: Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma
Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma Open
Angiosarcoma is an aggressive malignancy of vascular origin that occurs de novo or in the context of previous cancer therapy. Despite multi-modal aggressive treatment including surgical resection, chemotherapy, and radiation, five-y…
View article: DREADD Targeting Projections from the Nucleus Accumbens to the Ventral Pallidum with Nicotine Self-Administration
DREADD Targeting Projections from the Nucleus Accumbens to the Ventral Pallidum with Nicotine Self-Administration Open
Projections from the Nucleus Accumbens (NAc) to the Ventral Pallidum (VP) play a critical role in motivation and reward. Rewards and reward-associated cues are thought to alter this pathway by suppressing GABA release to the VP, however, t…
View article: CSIG-36. DECREASED CAPICUA (CIC) ENHANCES ONCOGENIC ETV4 SIGNALING IN A MOUSE MODEL OF ASTROCYTOMA AND GLIOMA STEM CELLS
CSIG-36. DECREASED CAPICUA (CIC) ENHANCES ONCOGENIC ETV4 SIGNALING IN A MOUSE MODEL OF ASTROCYTOMA AND GLIOMA STEM CELLS Open
High grade astrocytomas are brain tumors that currently have no cure. Understanding mechanisms that sustain and help them to resist therapy are urgently necessary. The capicua (CIC) transcriptional repressor is a target of receptor tyrosin…
View article: TMOD-10. INTRACRANIAL PATIENT-DERIVED XENOGRAFT FROM A PEDIATRIC GLIOBLASTOMA RETAINS MOLECULAR CHARACTERISTICS AND GROWTH PATHWAYS
TMOD-10. INTRACRANIAL PATIENT-DERIVED XENOGRAFT FROM A PEDIATRIC GLIOBLASTOMA RETAINS MOLECULAR CHARACTERISTICS AND GROWTH PATHWAYS Open
BACKGROUND: Pediatric glioblastomas (pGBM) are characterized by overlapping and unique molecular driver mutations compared to their adult counterparts. Primary cell cultures and patient-derived xenograft (PDX) models of pGBM are rare which…