Amanda Solem
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View article: Mode of Action of AlgE1: A Modular Mannuronate C-5 Epimerase
Mode of Action of AlgE1: A Modular Mannuronate C-5 Epimerase Open
The mannuronate C-5 epimerase AlgE1 from Azotobacter vinelandii introduces long blocks of guluronate (G) into alginate. AlgE1 is an elongated enzyme consisting of six modules, of which two are catalytically active modules (A-modules). For …
View article: Behind the screen: drug discovery using the big data of phenotypic analysis
Behind the screen: drug discovery using the big data of phenotypic analysis Open
Technological advances in drug discovery are exciting to students, but it is challenging for faculty to maintain the pace with these developments, particularly within undergraduate courses. In recent years, a High-throughput Discovery Scie…
View article: Behind the screen: drug discovery using the big data of phenotypic analysis
Behind the screen: drug discovery using the big data of phenotypic analysis Open
Technological advances in drug discovery are exciting to students, but it is challenging for faculty to maintain the pace with these developments, particularly within undergraduate courses. In recent years, a High-throughput Discovery Scie…
View article: ATG8 is conserved between Saccharomyces cerevisiae and psychrophilic, polar-collected fungi
ATG8 is conserved between Saccharomyces cerevisiae and psychrophilic, polar-collected fungi Open
Autophagy is a stress response mechanism through which eukaryotic cells target and sequester unnecessary or damaged cellular components for degradation and recycling. The hallmark of the autophagy process is the formation of a large (600-9…
View article: Multiple conformations are a conserved and regulatory feature of the RB1 5′ UTR
Multiple conformations are a conserved and regulatory feature of the RB1 5′ UTR Open
Folding to a well-defined conformation is essential for the function of structured ribonucleic acids (RNAs) like the ribosome and tRNA. Structured elements in the untranslated regions (UTRs) of specific messenger RNAs (mRNAs) are known to …
View article: Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson Open
There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for who…
View article: Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark
Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark Open
Ribonucleic acid (RNA) secondary structure prediction continues to be a significant challenge, in particular when attempting to model sequences with less rigidly defined structures, such as messenger and non-coding RNAs. Crucial to interpr…
View article: Multiple conformations are a conserved and regulatory feature of the RB1 5' UTR
Multiple conformations are a conserved and regulatory feature of the RB1 5' UTR Open
Folding to a well-defined conformation is essential for the function of structured ribonucleic acids (RNAs) like the ribosome and tRNA. Structured elements in the untranslated regions (UTRs) of specific messenger RNAs (mRNAs) are known to …
View article: An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression
An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression Open
Protein and mRNA expression are in most cases poorly correlated, which suggests that the posttranscriptional regulatory program of a cell is an important component of gene expression. This regulatory network is still poorly understood, inc…
View article: Using an Activity Based on Constructivism To Help Students Develop a More Integrated Understanding of Cell Signaling Pathways
Using an Activity Based on Constructivism To Help Students Develop a More Integrated Understanding of Cell Signaling Pathways Open
In subjects like cell biology, genetics, and immunology, a solid understanding of signal transduction is key to mastering new content. Often times students’ approach to learning signal transduction pathways relies heavily on memorization. …
View article: An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression
An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression Open
Significance Protein and mRNA expression are in most cases poorly correlated, which suggests that the posttranscriptional regulatory program of a cell is an important component of gene expression. This regulatory network is still poorly un…
View article: Impact of RNA structure on ZFP36L2 interaction with luteinizing hormone receptor mRNA
Impact of RNA structure on ZFP36L2 interaction with luteinizing hormone receptor mRNA Open
ZFP36L2 (L2) destabilizes AU-rich element (ARE)-containing transcripts and has been implicated in female fertility. We have shown that only one of three putative AREs within the 3′ UTR of murine luteinizing hormone receptor mRNA, ARE2197 (…
View article: Using the Improvisational “Yes, and…” Approach as a Review Technique in the Student-Centered Biology Classroom
Using the Improvisational “Yes, and…” Approach as a Review Technique in the Student-Centered Biology Classroom Open
In the biological sciences, students frequently equate understanding to compiling and memorizing information as a series of isolated facts. For this reason, they struggle to connect major concepts across course curriculums. In other discip…