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View article: B-Privacy: Defining and Enforcing Privacy in Weighted Voting
B-Privacy: Defining and Enforcing Privacy in Weighted Voting Open
In traditional, one-vote-per-person voting systems, privacy equates with ballot secrecy: voting tallies are published, but individual voters' choices are concealed. Voting systems that weight votes in proportion to token holdings, though, …
View article: Secure Sharing of Electronic Medical Records Based on Blockchain and Searchable Encryption
Secure Sharing of Electronic Medical Records Based on Blockchain and Searchable Encryption Open
In recent years, Electronic Medical Record (EMR) sharing has played an indispensable role in optimizing clinical treatment plans, advancing medical research in biomedical science. However, existing EMR management schemes often face securit…
View article: Rooster Behavior and Laying Breeder Performance in Natural Mating Cages as a Function of Different Rearing Management
Rooster Behavior and Laying Breeder Performance in Natural Mating Cages as a Function of Different Rearing Management Open
Natural mating colony cages are crucial in poultry breeding, yet breed-specific management requires further investigation. We evaluated the effects of sex ratios, stocking densities, and cohabitation age on Lohmann Pink-shell breeders’ per…
View article: Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection
Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection Open
View article: Efficient Searchable Encryption Scheme Supporting Fuzzy Multi-Keyword Ranking Search on Blockchain
Efficient Searchable Encryption Scheme Supporting Fuzzy Multi-Keyword Ranking Search on Blockchain Open
View article: The transcriptome of CD14<sup>+</sup>CD163<sup>-</sup>HLA-DR<sup>low</sup>monocytes predicts mortality in Idiopathic Pulmonary Fibrosis
The transcriptome of CD14<sup>+</sup>CD163<sup>-</sup>HLA-DR<sup>low</sup>monocytes predicts mortality in Idiopathic Pulmonary Fibrosis Open
Rationale The association between immune-cell-specific transcriptomic profiles and Idiopathic Pulmonary Fibrosis (IPF) mortality is unknown. Objectives To determine immune-cell-specific transcriptomic profiles associated with IPF mortality…
View article: Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis
Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis Open
Rationale: Fibrotic hypersensitivity pneumonitis (FHP) is a debilitating interstitial lung disease driven by incompletely understood immune mechanisms. Objectives: To elucidate immune aberrations in FHP in single-cell resolut…
View article: Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis
Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis Open
Rationale: Changes in peripheral blood cell populations have been observed, but not detailed, at single-cell resolution in idiopathic pulmonary fibrosis (IPF). Objectives: We sought to provide an atlas of the changes in the p…
View article: Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection
Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection Open
Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses th…
View article: Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner
Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner Open
MCEMP1 is highly expressed in circulating classical monocytes and alveolar macrophages in IPF, is regulated by TGFβ, and participates in the chemotaxis, adhesion, and migration of circulating monocytes by modulating the effect of TGFβ in R…
View article: MSF journal articles: What do we publish, where, and is it free to read?
MSF journal articles: What do we publish, where, and is it free to read? Open
View article: Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner
Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner Open
Background Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is higher in Idiopathic Pulmonary Fibrosis (IPF) patients with increased risk of death and poor outcomes. Here we seek to establish the mechanistic role of MCEMP1 in pulmonary fibr…
View article: Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung Diseases
Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung Diseases Open
Rationale and Objectives The extent and commonality of peripheral blood immune aberrations in fibrotic interstitial lung diseases are not well characterized. In this study, we aimed to identify common and distinct immune aberrations in pat…
View article: Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis
Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis Open
Rationale Changes in peripheral blood cell populations have been observed but not detailed at single-cell resolution in idiopathic pulmonary fibrosis (IPF). Objectives To provide an atlas of the changes in the peripheral immune system in s…
View article: From COVID to fibrosis: lessons from single-cell analyses of the human lung
From COVID to fibrosis: lessons from single-cell analyses of the human lung Open
View article: Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 Open
View article: Correction to: Surgical strategies for older patients with glioblastoma
Correction to: Surgical strategies for older patients with glioblastoma Open
View article: Surgical strategies for older patients with glioblastoma
Surgical strategies for older patients with glioblastoma Open
Objective While adjuvant treatment regimens have been modified for older patients with glioblastoma (GBM), surgical strategies have not been tailored. Methods Clinical data of 48 consecutive patients aged 70 years or older, who underwent s…
View article: PATH-39. ASSOCIATIONS OF GENOMIC SUBGROUP WITH RECURRENCE IN LOW-GRADE MENINGIOMAS
PATH-39. ASSOCIATIONS OF GENOMIC SUBGROUP WITH RECURRENCE IN LOW-GRADE MENINGIOMAS Open
Up to 80% of meningiomas are classified as clinically low-grade, however, a subset of these ‘benign’ cases will ultimately recur and require additional treatment. The role of molecular subgroup in meningioma recurrence has not been thoroug…
View article: Associations of meningioma molecular subgroup and tumor recurrence
Associations of meningioma molecular subgroup and tumor recurrence Open
Background We and others have identified mutually exclusive molecular subgroups of meningiomas; however, the implications of this classification for clinical prognostication remain unclear. Integrated genomic and epigenomic analyses implic…
View article: Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19
Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19 Open
A dysregulated immune response against the SARS-CoV-2 virus plays a critical role in severe COVID-19. However, the molecular and cellular mechanisms by which the virus causes lethal immunopathology are poorly understood. Here, we utilize m…
View article: Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene Signature
Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene Signature Open
View article: The Clinical Implications of Spontaneous Hemorrhage in Vestibular Schwannomas
The Clinical Implications of Spontaneous Hemorrhage in Vestibular Schwannomas Open
Background Spontaneous hemorrhage into vestibular schwannomas (VSs) is rare and can render more rapid symptom onset and a seemingly poorer prognosis for an otherwise benign pathology. We describe our series of hemorrhagic VS (HVSs) and sys…
View article: GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP
GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP Open
BACKGROUND Meningiomas can be classified into six genomic subgroups based on mutations in NF2, SMARCB1, KLF4, POLR2A, or activating variants in the PI3K or Hedgehog signaling pathways. Previous work has identified specific associations of …
View article: HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE
HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE Open
INTRODUCTION Vestibular schwannomas (VS) are known to be slow-growing lesions that can present significant issues for patients. Here, we sought to better understand their outcomes and risks for recurrence. METHODS We retrospectively review…
View article: MNGI-09. MENINGIOMA WITH MULTIPLE DRIVERS: GENOMIC LANDSCAPE AND CLINICAL CORRELATIONS
MNGI-09. MENINGIOMA WITH MULTIPLE DRIVERS: GENOMIC LANDSCAPE AND CLINICAL CORRELATIONS Open
BACKGROUND Previous studies have established several meningioma genomic subgroups, defined by the mutually exclusive genomic drivers. However, we distinguished a small subset of meningiomas simultaneously harboring multiple drivers from di…
View article: <i>DNMT3A</i> co-mutation in an <i>IDH1</i>-mutant glioblastoma
<i>DNMT3A</i> co-mutation in an <i>IDH1</i>-mutant glioblastoma Open
Glioblastomas are highly aggressive, infiltrative, and genetically heterogeneous primary brain tumors that arise de novo or secondarily progress over time from low-grade tumors. Along with well-established signature mutational profiles, em…
View article: Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits
Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits Open
View article: Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks
Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks Open
Poly(ADP ribose) polymerase inhibitors (PARPi) target cancer cells deficient in homology-directed repair of DNA double-strand breaks (DSBs). In preclinical models, PARPi resistance is tied to altered nucleolytic processing (resection) at t…
View article: Author response: Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks
Author response: Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Poly(ADP ribose) polymerase i…