Amandine Alard YOU? Author Swipe

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Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation Open

Amandine Alard, Olga Katsara, Tiffany J. Rios-Fuller, Columba de la Parra, Uğur Özerdem , et al. · 2023

Figure S1 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Gating strategy of intratumoral CD8+ T cells.

Data from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Increased regulatory T cells (Treg) after radiotherapy have been reported, but the mechanisms of their induction remain incompletely understood. TGFβ is known to foster Treg differentiation within tumors and is activated following radiothe…

Figure S4 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

INHBA expression correlates with the tumor-infiltrating Treg score in ER positive and negative breast cancer patients.

Figure S3 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Characterization of Inhba knock-in in TSA cell.

Supplementary Figure Legend from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Supplementary Figure Legend

Figure S1 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Gating strategy of intratumoral CD8+ T cells.

Figure S3 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Characterization of Inhba knock-in in TSA cell.

Figure S2 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Characterization of Inhba knockdown in 4T1 cells.

Figure S4 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

INHBA expression correlates with the tumor-infiltrating Treg score in ER positive and negative breast cancer patients.

Supplementary Figure Legend from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Supplementary Figure Legend

Figure S2 from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Characterization of Inhba knockdown in 4T1 cells.

Data from Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2023

Increased regulatory T cells (Treg) after radiotherapy have been reported, but the mechanisms of their induction remain incompletely understood. TGFβ is known to foster Treg differentiation within tumors and is activated following radiothe…

Data from Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer Open

Fernanda Musa, Amandine Alard, Gizelka David‐West, John P. Curtin, Stephanie V. Blank , et al. · 2023

There is considerable interest in the clinical development of inhibitors of mTOR complexes mTORC1 and 2. Because mTORC1 and its downstream mRNA translation effectors may protect against genotoxic DNA damage, we investigated the inhibition …

Supplementary Figures 1-3 with legends from Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer Open

Fernanda Musa, Amandine Alard, Gizelka David‐West, John P. Curtin, Stephanie V. Blank , et al. · 2023

Supplementary Figure S1: Growth inhibitory 50% (GI50) determination of single agent everolimus, PP242 and carboplatin using OVCAR-3 cells; Supplementary Figure S2: mTORC1 and mTORC1/2 inhibition sensitizes platinum resistant SKOV3 cells to…

Data from Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer Open

Fernanda Musa, Amandine Alard, Gizelka David‐West, John P. Curtin, Stephanie V. Blank , et al. · 2023

There is considerable interest in the clinical development of inhibitors of mTOR complexes mTORC1 and 2. Because mTORC1 and its downstream mRNA translation effectors may protect against genotoxic DNA damage, we investigated the inhibition …

Supplementary Figures 1-3 with legends from Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer Open

Fernanda Musa, Amandine Alard, Gizelka David‐West, John P. Curtin, Stephanie V. Blank , et al. · 2023

Supplementary Figure S1: Growth inhibitory 50% (GI50) determination of single agent everolimus, PP242 and carboplatin using OVCAR-3 cells; Supplementary Figure S2: mTORC1 and mTORC1/2 inhibition sensitizes platinum resistant SKOV3 cells to…

Phosphorylation of the MNK1 substrate eIF4E is not required for response to acute pancreatitis Open

Amandine Alard, Manon Strehaïano, David C. Muller, Charline Lasfargues, Stéphanie Cassant‐Sourdy , et al. · 2021

eIF4E phosphorylation is not required for response to pancreatitis indicating that the acinar-cell-specific MNK1 kinase acts in acute pancreatitis via another substrate.

Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer Open

Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard , et al. · 2020

Increased regulatory T cells (Treg) after radiotherapy have been reported, but the mechanisms of their induction remain incompletely understood. TGFβ is known to foster Treg differentiation within tumors and is activated following radiothe…

<span>FAK</span> activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer Open

Sonia Zaghdoudi, Emilie Decaup, Ismahane Belhabib, Rémi Samain, Stéphanie Cassant‐Sourdy , et al. · 2020

Cancer-associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs …

Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome Open

Amandine Alard, Catherine Marbœuf, Bertrand Fabre, Christine Jean, Yvan Martineau , et al. · 2019

The 4G family of eukaryotic mRNA translation initiation factors is composed of three members (eIF4GI, eIF4GII, and DAP5). Their specific roles in translation initiation are under intense investigations, but how their respective intracellul…

A widespread alternate form of cap-dependent mRNA translation initiation Open

Columba de la Parra, Amanda Ernlund, Amandine Alard, Kelly V. Ruggles, Beatrix Ueberheide , et al. · 2018

Translation initiation of most mammalian mRNAs is mediated by a 5′ cap structure that binds eukaryotic initiation factor 4E (eIF4E). However, inactivation of eIF4E does not impair translation of many capped mRNAs, suggesting an unknown alt…

Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming Open

Phillip A. Geter, Amanda Ernlund, Sofia Bakogianni, Amandine Alard, Rezina Arju , et al. · 2017

The majority of breast cancers expresses the estrogen receptor (ER + ) and is treated with anti-estrogen therapies, particularly tamoxifen in premenopausal women. However, tamoxifen resistance is responsible for a large proportion of breas…

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity Open

Claire Vanpouille‐Box, Amandine Alard, Molykutty J. Aryankalayil, Yasmeen Sarfraz, Julie M. Diamond , et al. · 2017

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiatio…

The efficacy of mTORC1/2 inhibition on ovarian cancer stem cells Open

Jing‐Yi Chern, Melissa K. Frey, Fernanda Musa, Amandine Alard, Chohee Yun , et al. · 2016

Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer Open

Fernanda Musa, Amandine Alard, Gizelka David‐West, John P. Curtin, Stephanie V. Blank , et al. · 2016

There is considerable interest in the clinical development of inhibitors of mTOR complexes mTORC1 and 2. Because mTORC1 and its downstream mRNA translation effectors may protect against genotoxic DNA damage, we investigated the inhibition …

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