Amani Yehya
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View article: Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using 2D and 3D in vitro culture models
Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using 2D and 3D in vitro culture models Open
Introduction Drug repurposing is gaining consideration in cancer due to the challenges of poor outcomes and resistance associated with the current conventional modalities. Non-steroidal anti-inflammatory drugs (NSAIDs), widely used for tre…
View article: Effect of Inorganic Phosphorus Manipulation on the Growth and Progression of Prostate Cancer Cells In Vitro
Effect of Inorganic Phosphorus Manipulation on the Growth and Progression of Prostate Cancer Cells In Vitro Open
Epidemiological studies have linked higher serum and dietary phosphorus to an increased risk of prostate cancer (PC) and its lethal state. However, these findings do not distinguish between the impact of inorganic phosphorus (Pi) per se an…
View article: The intricacies of Acinetobacter baumannii: a multifaceted comprehensive review of a multidrug-resistant pathogen and its clinical significance and implications
The intricacies of Acinetobacter baumannii: a multifaceted comprehensive review of a multidrug-resistant pathogen and its clinical significance and implications Open
Acinetobacter baumannii , a highly adaptive and formidable nosocomial pathogen, has emerged as a symbol of modern medicine's struggle against multidrug resistance (MDR). As a Gram-negative dweller in moist hospital environments, A. baumann…
View article: Effect of Inorganic Phosphorus Manipulation on the Growth and Progression of Prostate Cancer Cells in vitro
Effect of Inorganic Phosphorus Manipulation on the Growth and Progression of Prostate Cancer Cells in vitro Open
Epidemiological studies have linked higher serum and dietary phosphorus to an in-creased risk of prostate cancer (PC) and its lethal state. These findings do not distinguish between the impact of inorganic phosphorus (Pi) per se or its hom…
View article: Contemporary Update on Clinical and Experimental Prostate Cancer Biomarkers: A Multi-Omics-Focused Approach to Detection and Risk Stratification
Contemporary Update on Clinical and Experimental Prostate Cancer Biomarkers: A Multi-Omics-Focused Approach to Detection and Risk Stratification Open
Prostate cancer remains a significant health challenge, being the most prevalent non-cutaneous cancer in men worldwide. This review discusses the critical advancements in biomarker discovery using single-omics and multi-omics approaches. M…
View article: Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells
Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells Open
BACKGROUND Embryonic stem cells (ESCs) serve as a crucial ex vivo model, representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos. ESCs exhibit a unique combination of self-renewal potency, unlimited prolife…
View article: Assessing Neuroprotective Effects of Mitoquinone on H2O2-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells
Assessing Neuroprotective Effects of Mitoquinone on H2O2-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells Open
Oxidative stress, a major player in secondary brain injury, has been shown to contribute to apoptosis, neuroinflammation, and mitochondrial dysfunction. The possibility of targeting the Nrf2-Keap-ARE pathway, using mitochondria-targeted an…
View article: Tissue-specific cancer stem/progenitor cells: Therapeutic implications
Tissue-specific cancer stem/progenitor cells: Therapeutic implications Open
Surgical resection, chemotherapy, and radiation are the standard therapeutic modalities for treating cancer. These approaches are intended to target the more mature and rapidly dividing cancer cells. However, they spare the relatively quie…
View article: MicroRNAs as clinical tools for diagnosis, prognosis, and therapy in prostate cancer
MicroRNAs as clinical tools for diagnosis, prognosis, and therapy in prostate cancer Open
Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men worldwide. Despite the presence of accumulated clinical strategies for PCa management, limited prognostic/sensitive biomarkers are available to follow up on dise…
View article: Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional <i>in vitro</i> models
Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional <i>in vitro</i> models Open
This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation.
View article: Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo
Drug resistance in metastatic castration-resistant prostate cancer: an update on the status quo Open
Prostate cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men globally. Despite improvements in the diagnosis and treatment of PCa, a significant proportion of patients with high-risk localized disease and all p…