Alok Singh
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Evaluation of Varietal and Location Effects on Growth, Yield and Economics of Potato (Solanum tuberosum L.) in Eastern Uttar Pradesh, India Open
Potato (Solanum tuberosum L.) is the fourth most important food crop globally after maize, wheat, and rice and plays a vital role in food and nutritional security. In India, it is a major Rabi crop with Uttar Pradesh as the leading produce…
Decades of discovery: unveiling emerging trends, pivotal research areas, and landmark publications in national tobacco research in India Open
Introduction Tobacco use remains a major public health concern in India, contributing significantly to the burden of non-communicable diseases and premature mortality. Over the past two decades, national tobacco research has evolved in res…
Smart Polymers in Controlled Drug Release: Mechanisms and Clinical Applications Open
Smart polymers, also referred to as stimuli-responsive polymers, represent a transformative class of materials in the field of drug delivery. These polymers have the unique ability to undergo reversible or irreversible physical and chemica…
Digital horizons in non-communicable disease care: a bibliometric exploration of intervention impact and innovation Open
Introduction Digital interventions show considerable promise in managing non-communicable diseases (NCDs) within primary healthcare. Aim The aim of this study was to conduct a comprehensive bibliometric analysis of research on digital inte…
Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis Open
Mycobacterium tuberculosis establishes within host cells by inducing anti-apoptotic Bcl-2 family proteins, triggering necrosis, inflammation, and fibrosis. Here, we demonstrate that navitoclax, an orally bioavailable, small-molecule Bcl-2 …
<i>In vitro</i> and <i>in vivo</i> synergy of Vancomycin and β-lactams against drug-resistant <i>Mycobacterium tuberculosis</i> and Non-tuberculous mycobacteria Open
The unabated increase in antimicrobial resistance has underlined the importance of identifying novel drug combinations which eliminate infections more potently and likely reduce the emergence of resistance. In this context, we have identif…
Assessing cognitive decline for effective screening: evaluating the efficacy of mini-mental status examination and Addenbrooke’s cognitive examination in identifying minimal hepatic encephalopathy in patients with compensated liver cirrhosis Open
Background: Liver cirrhosis is a progressive disease marked by significant liver scarring and functional impairment. Minimal hepatic encephalopathy (MHE), a common complication, has a global prevalence of 30-84%, and in India, up to 59.7% …
Tissue chips as headway model and incitement technology Open
Tissue on a chip or organ-on-chip (OOC) is a technology that's dignified to form a transformation in drug discovery through the use of advanced platforms. These are 3D in-vitro cell culture models that mimic micro-environment of human orga…
Preface to the second issue of Heart India 2024 Open
In this "Heart India" issue, we publish two review articles, five original research articles, six case reports, and one letter to the editor. Cardiovascular disorder (CVD) are the leading causes of death worldwide in both sexes alike. The …
8p Microdeletion Syndrome Presenting as Congenital Scoliosis and Facial Dysmorphism with Novel Anomalies Open
8p deletion is a multisystem congenital disorder manifesting since early infancy with global developmental delay and other organ involvement. In our case the presentation was at 6 months with back deformity and developmental delay, dysmorp…
Steroid Resistant Nephrotic Syndrome with Underlying Renal Amyloidosis Secondary to Systemic JIA: Rare Case Report Open
Nephrotic syndrome is mostly idiopathic but secondary causes are also not uncommon. In our case we had a steroid resistance case so on renal biopsy we found that it due to amyloidosis which was also attributed to systemic JIA. It showed re…
Virulence and pathogenicity determinants in whole genome sequence of Fusarium udum causing wilt of pigeon pea Open
The present study deals with whole genome analysis of Fusarium udum , a wilt causing pathogen of pigeon pea. The de novo assembly identified a total of 16,179 protein-coding genes, of which 11,892 genes (73.50%) were annotated using BlastP…
CCDC 2181714: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2181712: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2181713: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Unbiased approach to identify and assess efficacy of human SARS-CoV-2 neutralizing antibodies Open
Coronavirus disease 2019 (COVID-19) continues to significantly impact the global population, thus countermeasure platforms that enable rapid development of therapeutics against variants of SARS-CoV-2 are essential. We report use of a phage…
View article: Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants
Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants Open
The continual emergence of SARS-CoV-2 variants of concern, in particular the newly emerged Omicron (B.1.1.529) variant, has rendered ineffective a number of previously EUA approved SARS-CoV-2 neutralizing antibody therapies. Furthermore, e…
Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma Open
Ewing sarcoma (ES) is the second most common pediatric bone cancer. Despite recent advances in the treatment, patients with metastatic tumors have dismal prognosis and hence novel therapies are urgently needed to combat this cancer. A rece…
Performance of Canola (Brassica napus L.) at Different Age of Seedling under System of Mustard Intensification Open
Background: Rapeseed (Brassica napus L.) also known as ‘rape’ is bright yellow flowering member of family Brassicaceae, cultivated for its oil rich seed. It is third most important oilseed crop after soybean and oil palm. Despite an import…
Protective Effects of STI-2020 Antibody Delivered Post-Infection by the Intranasal or Intravenous Route in a Syrian Golden Hamster COVID-19 Model Open
We have previously reported that the SARS-CoV-2 neutralizing antibody, STI-2020, potently inhibits cytopathic effects of infection by genetically diverse clinical SARS-CoV-2 pandemic isolates in vitro, and has demonstrated efficacy in a ha…
A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity Open
The PI3K-AKT-mTOR pathway has been at the center of anti-cancer drug development1,2, but targeted inhibition of PI3K kinase activity is proven to provide a limited therapeutic effect and is often followed by the development of resistance t…