Amar Singh
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View article: Co-transplantation of mesenchymal stem cells and endothelial cells with islet grafts: A strategy to improve post-tx engraftment of pancreatic islets
Co-transplantation of mesenchymal stem cells and endothelial cells with islet grafts: A strategy to improve post-tx engraftment of pancreatic islets Open
Though islet transplantation is now being considered as a gold standard to cure type 1 diabetes in patients without the threat of unaware hypoglycemia and severe hypoglycemia episode, post-transplantation islet loss due to the loss of intr…
View article: Gut redox and microbiome: charting the roadmap to T-cell regulation
Gut redox and microbiome: charting the roadmap to T-cell regulation Open
The gastrointestinal (GI) tract redox environment, influenced by commensal microbiota and bacterial-derived metabolites, is crucial in shaping T-cell responses. Specifically, metabolites from gut microbiota (GM) exhibit robust anti-inflamm…
View article: Refinement of Risk-Stratification of Cytogenetically Normal Acute Myeloid Leukemia Adult Patients by MN1 Expression
Refinement of Risk-Stratification of Cytogenetically Normal Acute Myeloid Leukemia Adult Patients by MN1 Expression Open
MN1 expression is an independent predictor of outcome in CN-AML.
View article: Robotic Buccal Mucosa Graft Ureteroplasty for Complex Ureteral Stricture Disease: Early Outcomes at a Single Institution
Robotic Buccal Mucosa Graft Ureteroplasty for Complex Ureteral Stricture Disease: Early Outcomes at a Single Institution Open
Background: Complex ureteral stricture disease is a challenging surgical problem. Traditional approaches, such as ileal ureter interposition or renal auto-transplantation, have significant associated morbidity. Robotic Buccal Mucosal Graft…
View article: Unveiling Novel Avenues in mTOR-Targeted Therapeutics: Advancements in Glioblastoma Treatment
Unveiling Novel Avenues in mTOR-Targeted Therapeutics: Advancements in Glioblastoma Treatment Open
The mTOR signaling pathway plays a pivotal and intricate role in the pathogenesis of glioblastoma, driving tumorigenesis and proliferation. Mutations or deletions in the PTEN gene constitutively activate the mTOR pathway by expressing grow…
View article: Small Molecule Targeting Immune Cells: A Novel Approach for Cancer Treatment
Small Molecule Targeting Immune Cells: A Novel Approach for Cancer Treatment Open
Conventional and cancer immunotherapies encompass diverse strategies to address various cancer types and stages. However, combining these approaches often encounters limitations such as non-specific targeting, resistance development, and h…
View article: Comparison of Robotic Assisted Laparoscopic Radical Prostatectomy: SP versus XI, a Single Surgeon Experience
Comparison of Robotic Assisted Laparoscopic Radical Prostatectomy: SP versus XI, a Single Surgeon Experience Open
Introduction Currently there is a paucity of data regarding Single Port (SP) robotic-assisted laparoscopic prostatectomy (RALP). Our objective was to compare our single-institution single-surgeon SP RALP experience to our XI RALP experienc…
View article: The future treatment for type 1 diabetes: Pig islet- or stem cell-derived β cells?
The future treatment for type 1 diabetes: Pig islet- or stem cell-derived β cells? Open
Replacement of β cells is only a curative approach for type 1 diabetes (T1D) patients to avoid the threat of iatrogenic hypoglycemia. In this pursuit, islet allotransplantation under Edmonton’s protocol emerged as a medical miracle to atta…
View article: Prognostic relevance of <i>NPM1, CEBPA,</i> and <i>FLT3</i> mutations in cytogenetically normal adult AML patients.
Prognostic relevance of <i>NPM1, CEBPA,</i> and <i>FLT3</i> mutations in cytogenetically normal adult AML patients. Open
These findings indicate that NPM1 and CEBPA mutations can be precisely used for risk stratification in CN-AML patients.
View article: Prognostic relevance of surface expression of cytokine receptor-like factor 2 in pediatric B-lineage acute lymphoblastic leukemia.
Prognostic relevance of surface expression of cytokine receptor-like factor 2 in pediatric B-lineage acute lymphoblastic leukemia. Open
Overexpression of cytokine receptor-like factor 2 (CRLF2) resulting from its genomic rearrangement is the most frequent genetic alteration found in Philadelphia chromosome-like (Ph-like) B-cell acute lymphoblastic leukemia (B-ALL), a high-…
View article: Pan-Cancer Analysis Shows Enrichment of Macrophages, Overexpression of Checkpoint Molecules, Inhibitory Cytokines, and Immune Exhaustion Signatures in EMT-High Tumors
Pan-Cancer Analysis Shows Enrichment of Macrophages, Overexpression of Checkpoint Molecules, Inhibitory Cytokines, and Immune Exhaustion Signatures in EMT-High Tumors Open
Epithelial–mesenchymal transition (EMT) is a highly dynamic process that occurs under normal circumstances; however, EMT is also known to play a central role in tumor progression and metastasis. Furthermore, role of tumor immune microenvir…
View article: HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses
HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses Open
The human leukocyte antigen G1 (HLA-G1), a non-classical class I major histocompatibility complex (MHC-I) protein, is a potent immunomodulatory molecule at the maternal/fetal interface and other environments to regulate the cellular immune…
View article: Clinical evaluation of procalcitonin level after radiotherapy in cases of hepatobiliary and gastrointestinal malignancies
Clinical evaluation of procalcitonin level after radiotherapy in cases of hepatobiliary and gastrointestinal malignancies Open
Introduction:Apart from bacterial infections Procalcitonin (PCT) also increases in burns, trauma, and surgery.Methods: In a prospective study 45 cases (30 male and 15 female) of hepatobiliary and gastrointestinal cancer were taken, which w…
View article: Bladder diverticulectomy using a pre-peritoneal, trans-vesicle approach with the SP platform: A novel approach
Bladder diverticulectomy using a pre-peritoneal, trans-vesicle approach with the SP platform: A novel approach Open
A 64-year-old male with a history of urothelial carcinoma was found to have recurrence of his disease inside of a narrow neck bladder diverticulum on surveillance cystoscopy. The da Vinci Single Port robotic system was used to perform an e…
View article: PD23-11 COMPARISON OF ROBOTIC-ASSISTED LAPAROSCOPIC PROSTATECTOMY: SP versus XI, A SINGLE SURGEON EXPERIENCE
PD23-11 COMPARISON OF ROBOTIC-ASSISTED LAPAROSCOPIC PROSTATECTOMY: SP versus XI, A SINGLE SURGEON EXPERIENCE Open
You have accessJournal of UrologySurgical Technology & Simulation: Instrumentation & Technology II (PD23)1 Apr 2020PD23-11 COMPARISON OF ROBOTIC-ASSISTED LAPAROSCOPIC PROSTATECTOMY: SP versus XI, A SINGLE SURGEON EXPERIENCE Matthew Watson*…
View article: Noninvasive Fluorine-19 Magnetic Resonance Relaxometry Measurement of the Partial Pressure of Oxygen in Acellular Perfluorochemical-loaded Alginate Microcapsules Implanted in the Peritoneal Cavity of Nonhuman Primates
Noninvasive Fluorine-19 Magnetic Resonance Relaxometry Measurement of the Partial Pressure of Oxygen in Acellular Perfluorochemical-loaded Alginate Microcapsules Implanted in the Peritoneal Cavity of Nonhuman Primates Open
Background. We have utilized a noninvasive technique for measuring the partial pressure of oxygen (pO 2 ) in alginate microcapsules implanted intraperitoneally in healthy nonhuman primates (NHPs). Average pO 2 is important for determining …
View article: Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes Open
Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific tolerance to allografts in murine studies. Here we show…
View article: Ovarian type epithelial tumor of the tunica vaginalis with abdominal metastasis
Ovarian type epithelial tumor of the tunica vaginalis with abdominal metastasis Open
Malignant paratesticular tumors are rare. We describe the first documented case of a paratesticular serous ovarian type epithelial tumor (OTET) associated with abdominal metastasis and its treatment.
View article: Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice
Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice Open
These findings reveal that early and late rejection of pig islet xenografts may be dominated by different immune responses and that maintenance of long-term xenogeneic tolerance will require strategies that target the temporal sequence of …