Amarni Thomas
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View article: Transcriptional Regulation of RUNX1: An Informatics Analysis
Transcriptional Regulation of RUNX1: An Informatics Analysis Open
The RUNX1/AML1 gene encodes a developmental transcription factor that is an important regulator of haematopoiesis in vertebrates. Genetic disruptions to the RUNX1 gene are frequently associated with acute myeloid leukaemia. Gene regulatory…
View article: Cohesin facilitates zygotic genome activation in zebrafish
Cohesin facilitates zygotic genome activation in zebrafish Open
At zygotic genome activation (ZGA), changes in chromatin structure are associated with new transcription immediately following the maternal-to-zygotic transition (MZT). The nuclear architectural proteins cohesin and CCCTC-binding factor (C…
View article: Cohesin facilitates zygotic genome activation in zebrafish
Cohesin facilitates zygotic genome activation in zebrafish Open
At zygotic genome activation (ZGA), changes in chromatin structure are associated with new transcription immediately following the maternal-to-zygotic transition (MZT). The nuclear architectural proteins, cohesin and CCCTC-binding factor (…
View article: A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers
A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers Open
The transcription factor Runx1 is essential for definitive haematopoiesis, and the RUNX1 gene is frequently translocated or mutated in leukaemia. Runx1 is transcribed from two promoters, P1 and P2, to give rise to different protein isoform…
View article: A DNA Contact Map for the Mouse<i>Runx1</i>Gene Identifies Novel Hematopoietic Enhancers
A DNA Contact Map for the Mouse<i>Runx1</i>Gene Identifies Novel Hematopoietic Enhancers Open
The transcription factor Runx1 is essential for definitive hematopoiesis, and the RUNX1 gene is frequently translocated or mutated in leukemia. Runx1 is transcribed from two promoters, P1 and P2, to give rise to different protein isoforms.…