Amaury Bignaud
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View article: Replication coordination marks the domestication of large extrachromosomal replicons in bacteria
Replication coordination marks the domestication of large extrachromosomal replicons in bacteria Open
Bacterial genomes often include extrachromosomal replicons (ERs), ranging from small plasmids to nearly chromosome-sized elements, that foster genome plasticity and adaptation. Despite their prevalence, the mechanisms underlying ER domesti…
View article: Chromosome-level genome assembly of the European green woodpecker <i>Picus viridis</i>
Chromosome-level genome assembly of the European green woodpecker <i>Picus viridis</i> Open
The European green woodpecker, Picus viridis, is a widely distributed species found in the Western Palearctic region. Here, we assembled a highly contiguous genome assembly for this species using a combination of short- and long-read seque…
View article: Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeast <i>Lachancea kluyveri</i>
Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeast <i>Lachancea kluyveri</i> Open
Meiotic recombination shows broad variations across species and along chromosomes and is often suppressed at and around genomic regions determining sexual compatibility such as mating type loci in fungi. Here, we show that the absence of S…
View article: Transcription-induced domains form the elementary constraining building blocks of bacterial chromosomes
Transcription-induced domains form the elementary constraining building blocks of bacterial chromosomes Open
Transcription generates local topological and mechanical constraints on the DNA fiber, leading to the generation of supercoiled chromosome domains in bacteria. However, the global impact of transcription on chromosome organization remains …
View article: Chromosome-level genome assembly of the European Green woodpecker<i>Picus viridis</i>
Chromosome-level genome assembly of the European Green woodpecker<i>Picus viridis</i> Open
The European Green Woodpecker, Picus viridis , is a widely distributed species found in the Western Palearctic region. Here we assembled a highly contiguous genome assembly for this species using a combination of short and long reads seque…
View article: Chromosome folding and prophage activation reveal specific genomic architecture for intestinal bacteria
Chromosome folding and prophage activation reveal specific genomic architecture for intestinal bacteria Open
Background Bacteria and their viruses, bacteriophages, are the most abundant entities of the gut microbiota, a complex community of microorganisms associated with human health and disease. In this ecosystem, the interactions between these …
View article: Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization
Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization Open
Genomic sequences co-evolve with DNA-associated proteins to ensure the multiscale folding of long DNA molecules into functional chromosomes. In eukaryotes, different molecular complexes organize the chromosome’s hierarchical structure, ran…
View article: Transcriptional units form the elementary constraining building blocks of the bacterial chromosome
Transcriptional units form the elementary constraining building blocks of the bacterial chromosome Open
Transcription generates local topological and mechanical constraints along the DNA fiber, driving for instance the generation of supercoiled chromosomal domains in bacteria. However, the global impact of transcription-based regulation of c…
View article: Chromosome folding and prophage activation reveal gut-specific genome dynamics of bacteria in the OMM<sup>12</sup>consortium
Chromosome folding and prophage activation reveal gut-specific genome dynamics of bacteria in the OMM<sup>12</sup>consortium Open
Bacteria and their viruses, bacteriophages, are the most abundant entities of the gut microbiota, a complex community of microorganisms associated with human health and disease. In this ecosystem the interactions between these two key comp…