Amber Bozward
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View article: Spatial transcriptomics links hepatocyte-macrophage interactions to viral signatures in seronegative hepatitis
Spatial transcriptomics links hepatocyte-macrophage interactions to viral signatures in seronegative hepatitis Open
Background Seronegative hepatitis (SNH) is an acute fulminant liver injury which leads to liver failure, requiring urgent transplantation. Its clinical, biochemical, and histological features mimic autoimmune hepatitis (AIH). SNH aetiology…
View article: The dual role of TIGIT in regulatory and effector T cells in chronic liver disease
The dual role of TIGIT in regulatory and effector T cells in chronic liver disease Open
View article: Cellular interactions in self-directed immune-mediated liver diseases
Cellular interactions in self-directed immune-mediated liver diseases Open
The lymphocyte population must traverse a complex path throughout their journey to the liver. The signals which these cells must detect, including cytokines, chemokines and other soluble factors, steer their course towards further crosstal…
View article: Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells
Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells Open
View article: Expression of E-cadherin by large CD103+ CD69+ CD8+ T cells promotes their invasion into biliary epithelial cells
Expression of E-cadherin by large CD103+ CD69+ CD8+ T cells promotes their invasion into biliary epithelial cells Open
The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with Primary Biliary Cholangitis (PBC). Here, we characterise the of mechanism of CD8+ T cell entry into BEC…
View article: Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease
Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease Open
View article: Gut-Liver Immune Traffic: Deciphering Immune-Pathogenesis to Underpin Translational Therapy
Gut-Liver Immune Traffic: Deciphering Immune-Pathogenesis to Underpin Translational Therapy Open
The tight relationship between the gut and liver on embryological, anatomical and physiological levels inspired the concept of a gut-liver axis as a central element in the pathogenesis of gut-liver axis diseases. This axis refers to the re…
View article: Type 2 Autoimmune Hepatitis and Nonadherence to Medication Correlate With Premature Birth and Risk of Postpartum Flare
Type 2 Autoimmune Hepatitis and Nonadherence to Medication Correlate With Premature Birth and Risk of Postpartum Flare Open
Autoimmune hepatitis (AIH) is an immune‐mediated chronic liver disease that affects all ages, including women of childbearing age. Optimal management during pregnancy is poorly defined. We aimed to explore the clinical and biochemical cour…
View article: Natural Killer Cells and Regulatory T Cells Cross Talk in Hepatocellular Carcinoma: Exploring Therapeutic Options for the Next Decade
Natural Killer Cells and Regulatory T Cells Cross Talk in Hepatocellular Carcinoma: Exploring Therapeutic Options for the Next Decade Open
Despite major advances in immunotherapy, hepatocellular carcinoma (HCC) remains a challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune response, which can be manipulated for immunotherapeutic benefit …
View article: Autoimmune Hepatitis: Tolerogenic Immunological State During Pregnancy and Immune Escape in Post-partum
Autoimmune Hepatitis: Tolerogenic Immunological State During Pregnancy and Immune Escape in Post-partum Open
The maternal immune system engages in a fine balancing act during pregnancy by simultaneously maintaining immune tolerance to the fetus and immune responses to protect against invading organisms. Pregnancy is an intricately orchestrated pr…